A5029779433- Lipoproteins and Cardiovascular Health
- Hormonal Regulation and Hypertension
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic Associations and Epidemiology
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Lipid metabolism and disorders
- Sodium Intake and Health
- Renin-Angiotensin System Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Cancer, Lipids, and Metabolism
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Cholesterol and Lipid Metabolism
- Nutritional Studies and Diet
- Cardiac Imaging and Diagnostics
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Fatty Acid Research and Health
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Health and Disease Prevention
- Apelin-related biomedical research
University of Utah
2014-2023
Brown University
2020
Scottish Enterprise
2016
Sanofi (France)
2016
Regeneron (United States)
2016
Brigham and Women's Hospital
2000-2015
Pontificia Universidad Católica de Chile
2014-2015
Tufts Medical Center
2015
University of Chile
2015
Tufts University
2015
Few long-term or controlled studies of bariatric surgery have been conducted to date. We report the 12-year follow-up results an observational, prospective study Roux-en-Y gastric bypass that was in United States.A total 1156 patients with severe obesity comprised three groups: 418 who sought and underwent (surgery group), 417 but did not undergo (primarily for insurance reasons) (nonsurgery group 1), 321 seek 2). performed clinical examinations at baseline 2 years, 6 12 years ascertain...
Extreme obesity is associated with health and cardiovascular disease risks. Although gastric bypass surgery induces rapid weight loss ameliorates many of these risks in the short term, long-term outcomes are uncertain.To examine association Roux-en-Y (RYGB) loss, diabetes mellitus, other 6 years after surgery.A prospective Utah-based study conducted between July 2000 June 2011 1156 severely obese (body mass index [BMI] ≥ 35) participants aged 18 to 72 (82% women; mean BMI, 45.9; 95% CI,...
Primary aldosteronism is a nonsuppressible renin-independent aldosterone production that causes hypertension and cardiovascular disease.To characterize the prevalence of production, as well biochemically overt primary aldosteronism, in relation to blood pressure.Cross-sectional study.4 U.S. academic medical centers.Participants with normotension (n = 289), stage 1 115), 2 203), resistant 408).Participants completed an oral sodium suppression test, regardless or renin levels, confirmatory...
Despite weight loss recommendations to prevent cancer, cancer outcome studies after intentional are limited. Recently, reduced mortality following bariatric surgery has been reported. This study tested whether gastric bypass was due decreased incidence. Cancer incidence and data through 2007 from the Utah Registry (UCR) were compared between 6,596 patients who had (1984-2002) 9,442 severely obese persons applied for Driver's Licenses (1984-2002). Study outcomes included incidence,...
Iron overload is associated with increased diabetes risk. We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that decreased in diabetic patients. In humans, normal-range serum ferritin levels were inversely independent inflammation. Ferritin was and adiponectin type 2 obese subjects compared those equally individuals without metabolic syndrome. Mice fed a high-iron diet cultured adipocytes treated exhibited mRNA protein. found negatively regulated...
Whether menopausal hormone therapy (MHT) protects against cardiovascular disease (CVD) remains unclear.To assess atherosclerosis progression and CVD risk factors after MHT initiated in early menopause.Randomized, controlled trial. (ClinicalTrials.gov: NCT00154180).Nine U.S. academic centers.Healthy women aged 42 to 58 years between 6 36 months from last menses without prior events who had a coronary artery calcium (CAC) score less than 50 Agatston units not received estrogen or...
BACKGROUND. Ceramides are sphingolipids that play causative roles in diabetes and heart disease, with their serum levels measured clinically as biomarkers of cardiovascular disease (CVD).
Key points Five days of bed rest resulted in a reduction leg lean mass and strength older adults. After rest, (but not younger) adults had reduced amino acid‐induced anabolic sensitivity (blunted muscle protein synthesis; MPS) enhanced markers associated with the ubiquitin proteasome autophagy–lysosomal systems (increase molecular related to proteolysis). Younger did lose (via DXA) after 5 despite blunted mTORC1 signalling increased skeletal REDD1, REDD2 MURF1 mRNA expression. Exercise...
Abstract Mildly increased serum bilirubin has recently been suggested as a protective factor, possibly reducing the risk of coronary artery disease (CAD) by acting an antioxidant. We tested this hypothesis examining concentrations and other factors in 120 men 41 women with early familial CAD 155 control subjects. At screening, both cases subjects were 38 to 68 years old. Early patients had experienced myocardial infarction, bypass grafting, or angioplasty age 55 for 65 another sibling...
Background —Type 2 diabetes is a cardiovascular risk factor. It remains to be elucidated in large, population-based sample whether associated with changes left ventricular (LV) structure and systolic function independent of obesity blood pressure (BP). Methods Results —Among 1950 hypertensive participants the HyperGEN Study without overt coronary heart disease or significant valve disease, 20% (n=386) had diabetes. Diabetics were more likely women, black, older, have higher BMI waist/hip...
The relative contributions of genes and shared environment to cardiovascular risk factors were studied in twins pedigrees 1983–1985. Sitting, standing, isometric hand grip, bicycling, mentally stressed (serial subtraction) blood pressures obtained from 146 male monozygous twins, 162 dizygous 1,102 healthy adults 67 Utah pedigrees. Fasting total plasma cholesterol, triglycerides, high density lipoprotein cholesterol (HDL), body mass index also measured. Heritability was estimated before after...
HYPERCHOLESTEROLEMIA(FH) is a dominant genetic disorder first described by Muller 1 nearly 60 years ago.The elevated circulating low-density lipoprotein cholesterol (LDL-C) levels found in FH are caused defect receptor-mediated LDL clearance 2 and the underlying cause of marked increase early coronary artery disease (CAD). 3In men with untreated heterozygous (HeFH), risk clinically overt CAD approximately 5% age 30 years, 20% 40 50% 50 years. 3,4Only about 15% HeFH reach Context Heterozygous...
The degree to which ethnic differences in left ventricular structure among hypertensive adults are independent of clinical and hemodynamic factors remains uncertain. We assessed whether mass geometry differ between black white hypertensives after accounting for such factors. Our study group comprised 1060 580 participants free valvular or coronary disease a population-based cohort. Blood pressure was measured during clinic visit echocardiography performed using standardized protocols. After...
Background— Conventional wisdom suggests that a diagnosis of familial combined hyperlipidemia (FCHL) carries substantially greater risk premature coronary artery disease (CAD) than hypertriglyceridemia (FHTG). However, no population-based studies have critically addressed this issue. Methods and Results— FCHL FHTG were diagnosed in 10.2% 12.3% 334 random control families 16.7% 20.5% 293 with at least one case CAD. The either or an individual was associated odds ratio for CAD 2.0 ( P =0.003...
Abstract Context: The mechanisms underlying obesity-mediated cardiovascular disease are not fully understood. Aldosterone and insulin resistance both associated with obesity disease. Objectives: objectives of this study were to test the hypotheses that aldosterone production is elevated in overweight adults on a high-sodium diet. Participants/Interventions: Healthy normotensive categorized as lean body mass index (BMI) less than 25 kg/m2 (n = 63) or BMI greater 57). After 7 d diet,...
Objective To conduct an epigenome-wide analysis of DNA methylation and obesity traits. Methods was quantified in CD4+ T-cells using the Illumina Infinium HumanMethylation450 array 991 participants Genetics Lipid Lowering Drugs Diet Network. Methylation at individual cytosine-phosphate-guanine (CpG) sites as a function body mass index (BMI) waist circumference (WC), adjusting for age, gender, study site, T-cell purity, smoking, family structure, modeled. Results Epigenome-wide significant...