A5040832215- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- Nitric Oxide and Endothelin Effects
- Sex and Gender in Healthcare
- Pregnancy and preeclampsia studies
- Diversity and Career in Medicine
- Cerebrovascular and Carotid Artery Diseases
- Hormonal and reproductive studies
- Cardiovascular Health and Disease Prevention
- Transplantation: Methods and Outcomes
- Phytoestrogen effects and research
- Cardiovascular Issues in Pregnancy
- Birth, Development, and Health
- Atherosclerosis and Cardiovascular Diseases
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Extracellular vesicles in disease
- Cardiovascular Disease and Adiposity
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Acute Myocardial Infarction Research
- Cardiac Ischemia and Reperfusion
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
Mayo Clinic in Arizona
2016-2025
Mayo Clinic
2013-2024
WinnMed
2012-2024
Mayo Clinic in Florida
2014-2023
Ethnological Museum
2023
Lancaster General Hospital
2023
University of Pennsylvania Health System
2023
Individual Differences
2020
Miller College
2019
William S. Middleton Memorial Veterans Hospital
2016-2018
Background Menopausal hormone therapy (MHT) reportedly increases the risk of cognitive decline in women over age 65 y. It is unknown whether similar risks exist for recently postmenopausal women, and MHT affects mood younger women. The ancillary Cognitive Affective Study (KEEPS-Cog) Kronos Early Estrogen Prevention (KEEPS) examined effects up to 4 y on cognition Methods Findings KEEPS, a randomized, double-blinded, placebo-controlled clinical trial, was conducted at nine US academic centers....
Whether menopausal hormone therapy (MHT) protects against cardiovascular disease (CVD) remains unclear.To assess atherosclerosis progression and CVD risk factors after MHT initiated in early menopause.Randomized, controlled trial. (ClinicalTrials.gov: NCT00154180).Nine U.S. academic centers.Healthy women aged 42 to 58 years between 6 36 months from last menses without prior events who had a coronary artery calcium (CAC) score less than 50 Agatston units not received estrogen or...
Sex differences in hypertrophic cardiomyopathy (HCM) remain unclear. We sought to characterize sex a large HCM referral centre population.Three thousand six hundred and seventy-three adult patients with underwent evaluation between January 1975 September 2012 1661 (45.2%) female. Kaplan-Meier survival curves were assessed via log-rank test. Cox proportional hazard regression analyses evaluated the relation of survival. At index visit, women older (59 ± 16 vs. 52 15 years, P < 0.0001) had...
Analyses of circulating cell membrane-derived microvesicles (MV) have come under scrutiny as potential diagnostic and prognostic biomarkers disease. However, methods to isolate, label quantify MV been neither systematized nor validated.To determine how pre-analytical, analytical post-analytical factors affect plasma counts, markers for origin expression procoagulant surface phosphatidylserine.Peripheral venous blood samples were collected from healthy volunteers patients with cardiovascular...
Chronic treatment with estrogens enhances some endothelium-dependent relaxations. Whether or not progesterone would exert a similar effect is unknown. Experiments were designed to determine the of chronic on responses. Adult female dogs ovariectomized and pellets containing carrier substance, estrogen, progesterone, estrogen plus implanted subcutaneously. After 14-21 days coronary arteries removed, cut into rings, suspended for measurement isometric force in organ chambers presence...
Chronic increases in blood flow caused by an arteriovenous fistula augment endothelium-dependent relaxations to acetylcholine. To determine whether endothelial muscarinic receptors are altered, concentration-response curves acetylcholine were obtained the presence of pirenzepine fistula- and sham-operated canine femoral arteries. Pirenzepine inhibited response both The pA2 (log Kb) for antagonist was same. A bioassay system used assess release endothelium-derived relaxing factor. Rings...
Arachidonic acid produces endothelium-dependent relaxation in canine arteries and contraction veins. In femoral arteries, the is prevented by inhibitors of cyclooxygenase. To determine role cyclooxygenase evoked arachidonic veins, rings intrapulmonary with without endothelium, were suspended organ chambers set at their optimum length for isometric tension measurements. pulmonary vein contracted norepinephrine, produced a concentration-dependent increase that was eliminated removal...
Observational and epidemiological studies suggest that menopausal hormone therapy (MHT) reduces cardiovascular disease (CVD) risk. However, results from prospective trials showed neutral or adverse effects most likely due to differences in participant demographics, such as age, timing of initiation treatment, preexisting disease, which reflected part the lack basic science information on mechanisms action hormones vasculature at time clinical were designed. The Kronos Early Estrogen...
BackgroundHypertension is a risk factor for cerebrovascular disease and cognitive impairment. Women with hypertensive episodes during pregnancy report variable neurocognitive changes within the first decade following affected pregnancy. However, long-term follow-up of these women into their postmenopausal years has not been conducted.ObjectiveThe aim this study was to examine whether history preeclampsia were at increased decline 35-40 after pregnancy.Study DesignWomen identified recruited...