A5066125771- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Sodium Intake and Health
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
- Chronic Kidney Disease and Diabetes
- Cerebrovascular and Carotid Artery Diseases
- Antioxidant Activity and Oxidative Stress
- Receptor Mechanisms and Signaling
- Renal and Vascular Pathologies
- Cardiovascular Health and Risk Factors
- Mathematics Education and Programs
- Vitamin D Research Studies
- Alcohol Consumption and Health Effects
- Gout, Hyperuricemia, Uric Acid
- Apelin-related biomedical research
- Diverse Education Studies and Reforms
- Cardiac Health and Mental Health
- Neuroscience and Neuropharmacology Research
- Dialysis and Renal Disease Management
- Ion channel regulation and function
- Diet and metabolism studies
- Potassium and Related Disorders
Brigham and Women's Hospital
2016-2025
Harvard University
2012-2025
Mass General Brigham
2024-2025
University of Buckingham
2023
Arena Pharmaceuticals (United States)
2016
GTx (United States)
2016
Center for Clinical Research (United States)
2016
October 6 University
2016
VA Boston Healthcare System
2013
Geriatric Research Education and Clinical Center
2013
Background Consumption of flavonoid-rich beverages, including tea and red wine, has been associated with a reduction in coronary events, but the physiological mechanism remains obscure. Cocoa can contain extraordinary concentrations flavanols, flavonoid subclass shown to activate nitric oxide synthase vitro. Objective To test hypothesis that flavanol-rich cocoa induces nitric-oxide-dependent vasodilation humans. Design The study prospectively assessed effects Flavanol-rich cocoa, using both...
Vitamin D regulates the renin-angiotensin system (RAS) in experimental animals, but corresponding human data are limited. We examined relation between plasma 25-hydroxyvitamin and elements of RAS 184 normotensive individuals high sodium balance; these included circulating levels renin activity angiotensin II (Ang II) renal flow response to infused Ang II, which is an indirect measure intrinsic kidney. Compared with sufficient (≥30.0 ng/mL), those insufficiency (15.0 29.9 ng/mL) deficiency...
Importance Two initial sham-controlled trials demonstrated that ultrasound renal denervation decreases blood pressure (BP) in patients with mild to moderate hypertension and is resistant treatment. Objective To study the efficacy safety of without confounding influence antihypertensive medications hypertension. Design, Setting, Participants Sham-controlled, randomized clinical trial outcome assessors blinded treatment assignment was conducted between January 14, 2019, March 25, 2022, at 37...
Ultrasound renal denervation (uRDN) was shown to lower blood pressure (BP) in patients with uncontrolled hypertension (HTN). Establishing the magnitude and consistency of uRDN effect across HTN spectrum is clinically important.
Abstract. Although diabetic nephropathy is often a low renin state, the system appears to be implicated in its pathogenesis. In this study, it was hypothesized that plasma activity (PRA) misleading, masking and perhaps reflecting an activated intrarenal system. PRA renal vascular responses (inulin para-aminohippurate clearance) graded doses of angiotensin II (AngII) antagonist, irbesartan, were assessed eight healthy volunteers 12 patients with type 2 diabetes mellitus on 10 mmol Na intake,...
Pharmacological interruption of the renin-angiotensin system focuses on optimization blockade. As a measure intrarenal renin activity, we have examined renal plasma flow (RPF) responses in standardized protocol. Compared with angiotensin-converting enzyme inhibition (rise RPF approximately 95 mL x min(-1) 1.73 m(-2)), greater vasodilation angiotensin receptor blockers (approximately 145 m(-2)) suggested more effective We predicted that blockade direct oral inhibitor aliskiren would produce...
White matter hyperintensities (WMH) in elderly individuals with vascular diseases are presumed to be due ischemic small vessel diseases; however, their etiology is unknown. We examined the cross-sectional relationship between cerebrovascular hemodynamics and white structural integrity risk factors. hyperintensity volumes, fractional anisotropy (FA), mean diffusivity (MD) were obtained from MRI 48 subjects (75±7years). Pulsatility index (PI) dynamic cerebral autoregulation (dCA) was assessed...
<h3>Objective:</h3> To investigate the relationship between neurovascular coupling and cognitive function in elderly individuals with vascular risk factors to determine whether could be modified by cocoa consumption. <h3>Methods:</h3> Sixty older people (aged 72.9 ± 5.4 years) were studied a parallel-arm, double-blind clinical trial of cognition response 24 hours 30 days Cognitive measures included Mini-Mental State Examination Trail Making Test A B. Neurovascular was measured from...
Background: The multicenter, international, randomized, blinded, sham-controlled RADIANCE-HTN SOLO trial (A Study of the ReCor Medical Paradise System in Clinical Hypertension) demonstrated a 6.3 mm Hg greater reduction daytime ambulatory systolic blood pressure (BP) at 2 months by endovascular ultrasound renal denervation (RDN) compared with sham procedure among patients not treated antihypertensive medications. We report 6-month results after addition recommended standardized stepped-care...
Disruption of vitamin D signaling in rodents causes activation the rennin-angiotensin system (RAS) and development hypertension. Observational studies humans found lower circulating 25-hydroxyvitamin [25(OH)D] is associated with increased RAS activity blood pressure (BP). We performed first randomized control trial to investigate effects supplementation on humans.Vitamin deficient, [25(OH)D ≤20 ng/ml), overweight individuals without hypertension were into a double-blind, placebo-controlled...
Background and objectives Higher serum uric acid levels, even within the reference range, are strongly associated with increased activity of renin-angiotensin system (RAS) risk incident hypertension. However, effect lowering on RAS in humans is unknown, although data that can reduce BP conflicting. Design, setting, participants, & measurements In a double-blind placebo-controlled trial conducted from 2011 to 2015, we randomly assigned 149 overweight or obese adults ≥5.0 mg/dl either...
Importance Blood pressure (BP) and cholesterol control remain challenging. Remote care can deliver more effective outside of traditional clinician-patient settings but scaling ensuring access to among diverse populations remains elusive. Objective To implement evaluate a remote hypertension management program across health network. Design, Setting, Participants Between January 2018 July 2021, 20 454 patients in large integrated network were screened; 18 444 approached, 10 803 enrolled...
Background The COVID‐19 pandemic disrupted traditional health care; one fallout was a drastic decrease in blood pressure (BP) assessment. We analyzed the pandemic's impact on our existing remote hypertension management program's effectiveness and adaptability. Methods Results This retrospective observational analysis evaluated BP control an entirely program before during pandemic. A team of pharmacists, nurse practitioners, physicians, nonlicensed navigators used evidence‐based clinical...
Abstract Resistant hypertension is defined as blood pressure that remains above the therapeutic goal despite concurrent use of at least three antihypertensive agents different classes, including a diuretic, with all administered maximum or maximally tolerated doses. also diagnosed if control requires four more drugs. Assessment exclusion apparent treatment resistant hypertension, which most often result non-adherence to treatment. associated major cardiovascular events in short and long...
Abstract Background Remote hypertension management programs have emerged as potential solutions to improve poor rates of blood pressure (BP) control. The Continual Versus Occasional Blood Pressure (COOL-BP) Study investigated the feasibility and efficacy using a cuffless wrist BP monitor in remote (HTN) program. Methods COOL-BP was prospective single-arm study within larger HTN program at Mass General Brigham (MGB). Participants had uncontrolled HTN, were already engaged MGB Hypertension...
Higher levels of albumin excretion within the normal range are associated with cardiovascular disease in high-risk individuals. Whether incremental increases urinary excretion, even range, development hypertension low-risk individuals is unknown. This study included 1065 postmenopausal women from first Nurses' Health Study and 1114 premenopausal second who had an albumin/creatinine ratio <25 mg/g did not have diabetes or hypertension. Among older women, 271 incident cases occurred during 4...