A5069242732- Systemic Lupus Erythematosus Research
- Heart Failure Treatment and Management
- Pharmaceutical Practices and Patient Outcomes
- Platelet Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacology and Obesity Treatment
- Cardiovascular Health and Risk Factors
- Mechanical Circulatory Support Devices
- Diabetes Treatment and Management
- Blood Pressure and Hypertension Studies
- Machine Learning in Healthcare
- Liver Diseases and Immunity
- Atrial Fibrillation Management and Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Potassium and Related Disorders
- Non-Invasive Vital Sign Monitoring
- IgG4-Related and Inflammatory Diseases
- Topic Modeling
- Cardiac Valve Diseases and Treatments
- Blood disorders and treatments
- Artificial Intelligence in Healthcare and Education
- Cardiac, Anesthesia and Surgical Outcomes
Brigham and Women's Hospital
2022-2025
Harvard University
2022-2025
Broad Institute
2025
Mass General Brigham
2023-2025
Political Research Associates
2025
Massachusetts General Hospital
2024
Curry College
2023
Cornell University
2015-2022
Presbyterian Hospital
2020-2022
Weill Cornell Medicine
2017-2021
Background: Despite potential harm that can result from polypharmacy, real-world data on polypharmacy in the setting of heart failure (HF) are limited. We sought to address this knowledge gap by studying older adults hospitalized for HF derived REGARDS study (Reasons Geographic and Racial Differences Stroke). Methods: examined 558 aged ≥65 years with adjudicated hospitalizations 380 hospitals across United States. collected baseline assessment, medical charts HF-adjudicated hospitalizations,...
Subject screening is a key aspect of all clinical trials; however, traditionally, it labor-intensive and error-prone task, demanding significant time resources. With the advent large language models (LLMs) related technologies, paradigm shift in natural processing capabilities offers promising avenue for increasing both quality efficiency efforts. This study aimed to test Retrieval-Augmented Generation (RAG) process enabled Generative Pretrained Transformer Version 4 (GPT-4) accurately...
Abstract Background Remote hypertension management programs have emerged as potential solutions to improve poor rates of blood pressure (BP) control. The Continual Versus Occasional Blood Pressure (COOL-BP) Study investigated the feasibility and efficacy using a cuffless wrist BP monitor in remote (HTN) program. Methods COOL-BP was prospective single-arm study within larger HTN program at Mass General Brigham (MGB). Participants had uncontrolled HTN, were already engaged MGB Hypertension...
BackgroundScreening participants in clinical trials is an error-prone and labor-intensive process that requires significant time resources. Large language models such as generative pretrained transformer 4 (GPT-4) present opportunity to enhance the screening with advanced natural processing. This study evaluates utility of a Retrieval-Augmented Generation (RAG)–enabled GPT-4 system improve accuracy, efficiency, reliability for trial involving patients symptomatic heart failure.MethodsThe...
This randomized clinical trial compares the efficiency of prescreening patients with heart failure using an artificial intelligence (AI) large language model for inclusion in a vs manual prescreening.
Objective The objective of this study was to determine the efficacy hydroxychloroquine (HCQ) in primary thrombosis prevention antiphospholipid antibody (aPL)-positive patients with no other systemic autoimmune diseases. Methods Under auspices Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking, a multicenter, international, randomized controlled trial (RCT) initiated, which persistently aPL-positive but thrombosis-free without diseases were receive HCQ or...
Management for patients with antiphospholipid syndrome (APS) and arterial thrombosis is controversial. There are no prospective data demonstrating the superiority of high- or moderate-intensity anticoagulation vitamin K antagonists over antiplatelet agents. Using 2 antibody databases (single center [New York Presbyterian Hospital] multicenter [Antiphospholipid Syndrome Alliance Clinical Trials International Networking]), we retrospectively collected demographic clinical APS thrombosis. The...
Objective Although systemic lupus erythematosus ( SLE ) is the most common autoimmune disease associated with antiphospholipid antibodies aPL ), limited data exist regarding impact of on clinical phenotype ‐positive patients. The primary objective this study was to compare clinical, laboratory, and treatment characteristics patients those without SLE. Methods A secure web‐based capture system used store patient demographic ‐related laboratory characteristics. Inclusion criteria included...
Importance Disease characteristics of genetically mediated coronary artery disease (CAD) on angiography and the association genomic risk with outcomes after are not well understood. Objective To assess angiographic post–coronary patients drivers CAD: familial hypercholesterolemia (FH), high polygenic score (PRS), clonal hematopoiesis indeterminate potential (CHIP). Design, Setting, Participants A retrospective cohort study 3518 Mass General Brigham Biobank participants information who...
Mineralocorticoid receptor antagonists (MRAs) are disease-modifying agents indicated for heart failure (HF) that can augment diuresis and treat hypokalemia but underutilized. Prescribing MRAs instead of potassium supplements to in the setting HF could increase use MRAs. A best practice alert (BPA) electronic medical record suggests ordering an MRA supplementation a patient with facilitate this. This study sought examine perspectives primary care physicians on utilization BPA usefulness...
Infodemiology of antiphospholipid syndrome: Merging informatics and epidemiologyInvestigating the prevalence features rare conditions requires multicentre efforts.However, low diseases makes funding arduous and, for similar reasons, randomized controlled trials difficult to conduct.In "world wide web era" new tools are available researchers clinicians, especially study sub-groups populations.By extrapolating relative search data, one can obtain information on how patients navigate t he...
Underprescribing of guideline-directed medical therapy (GDMT) for heart failure (HF) persists.
The objective of this study was to describe the prevalence obesity, obesity-related conditions (ORCs), and antiobesity medication (AOM) eligibility prescribing practice among eligible patients in a large health care system.
Direct oral anticoagulants (DOACs) are effective alternatives to warfarin for stroke prevention in patients with atrial fibrillation (AF) including CKD III. However, data on patient outcomes DOACs advanced limited, while use is controversial.A retrospective study of AF using and stages III-V was conducted. The primary were or systemic embolism major bleeding DOAC therapy among IV V patients. Rates from the trials previous studies referenced.Of 316 reviewed, 152 included mean CrCl 38.8...
Introduction: Remote medication management programs (RMMP) might be effective in optimizing guideline directed medical therapy (GDMT) for HFrEF. Identification of patients that can safely managed remotely and prioritization those with the highest need optimization is crucial, especially setting constrained resources. Methods: We analyzed records from our institutional enterprise data warehouse to identify HFrEF whom GDMT optimized by an RMMP within Mass General Brigham health system between...