A5026568654- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Medication Adherence and Compliance
- International Development and Aid
- Blood Pressure and Hypertension Studies
- Pharmacovigilance and Adverse Drug Reactions
- Dementia and Cognitive Impairment Research
- Pharmaceutical studies and practices
- Poverty, Education, and Child Welfare
- Patient Safety and Medication Errors
- Balance, Gait, and Falls Prevention
- Pain Management and Opioid Use
- Antibiotic Use and Resistance
- Intensive Care Unit Cognitive Disorders
- Schizophrenia research and treatment
- Global Peace and Security Dynamics
- Heart Failure Treatment and Management
- Opioid Use Disorder Treatment
- African history and culture studies
- Pharmacy and Medical Practices
- Frailty in Older Adults
- Healthcare cost, quality, practices
- African studies and sociopolitical issues
- Geriatric Care and Nursing Homes
- Urinary Tract Infections Management
VA Pittsburgh Healthcare System
2016-2025
Geriatric Research Education and Clinical Center
2016-2025
University of Pittsburgh
2015-2025
London School of Economics and Political Science
2012-2025
Hong Kong Metropolitan University
1995-2025
University College Cork
2023
The Open University
2000-2021
Brigham and Women's Hospital
2020
University of Pittsburgh Medical Center
2012-2020
Florida State University
2019
Many medications have anticholinergic effects.In general, anticholinergicinduced cognitive impairment is considered reversible on discontinuation of therapy.However, a few studies suggest that anticholinergics may be associated with an increased risk for dementia.OBJECTIVE To examine whether cumulative use higher incident dementia. DESIGN, SETTING, AND PARTICIPANTSProspective population-based cohort study using data from the Adult Changes in Thought Group Health, integrated health care...
OBJECTIVES: To determine whether current use of central nervous system (CNS)‐active medications, including benzodiazepines, antidepressants, anticonvulsants, and narcotics, increases the risk for subsequent falls. DESIGN: Prospective cohort study. SETTING: Four clinical centers in Baltimore, Maryland; Portland, Oregon; Minneapolis, Minnesota; Monongahela Valley, Pennsylvania. PARTICIPANTS: Eight thousand one hundred twenty‐seven women aged 65 older participating fourth examination Study...
To describe the prevalence, types, and consequences of adverse drug events (ADEs) in older outpatients with polypharmacy.A cohort study.General Medicine Clinic at Durham Veterans Affairs Medical Center.A total 167 high risk (taking > or = 5 scheduled medications) ambulatory veterans who participated a year long health service intervention trial.Potential ADEs were identified by asking patients during closeout interviews whether, past year, they had experienced any side effects, unwanted...
Amid all the complicated economic theories about causes and solutions to poverty, one idea is so basic it seems radical: just give money poor. Despite its sceptics, researchers have found again that cash transfers given significant portions of population transform lives recipients. Countries from Mexico South Africa Indonesia are giving directly poor discovering they use wisely – send their children school, start a business feed families. Directly challenging an aid industry thrives on...
Background: Despite potential harm that can result from polypharmacy, real-world data on polypharmacy in the setting of heart failure (HF) are limited. We sought to address this knowledge gap by studying older adults hospitalized for HF derived REGARDS study (Reasons Geographic and Racial Differences Stroke). Methods: examined 558 aged ≥65 years with adjudicated hospitalizations 380 hospitals across United States. collected baseline assessment, medical charts HF-adjudicated hospitalizations,...
<h3>Background</h3> Use of central nervous system (CNS) active medications may increase the risk for fractures. Prior studies are limited by incomplete control confounders. <h3>Methods</h3> To determine whether use CNS medications, including benzodiazepines, antidepressants, anticonvulsants, and narcotics, increases fracture in elderly, community-dwelling women, we examined these 4 categories a cohort 8127 older women followed participants prospectively incident nonspine fractures, hip...
Data were analyzed from household interviews of four population-based cohorts comprising the Established Populations for Epidemiologic studies Elderly to estimate prevalence prescription and nonprescription medication use among community-living elderly examine sociodemographic health factors related use. Prescription drugs used by 60–68% men 68–78% women. Nonprescription 52–68% 64–76% Use medications generally increased with age although was not associated age. Men women who smoked or...
Objectives: To determine the prevalence and predictors of unnecessary drug use at hospital discharge in frail elderly patients. Design: Cross‐sectional. Setting: Eleven Veterans Affairs Medical Centers. Participants: Three hundred eighty‐four older patients from Geriatric Evaluation Management Drug Study. Measurements: Assessment was determined by consensus a clinical pharmacist physician pair applying Medication Appropriateness Index to each regularly scheduled medication discharge. Those...
Background. Adverse drug reactions (ADR) negatively impact life quality and are sometimes fatal. This study examines the incidence predictors of all preventable ADRs in frail elderly persons after hospital discharge, a highly vulnerable but rarely studied population. Methods. The design was prospective cohort involving 808 who were discharged from 11 Veteran Affairs hospitals to outpatient care. main outcome measure number per patient as determined by blinded geriatrician geropharmacist...
Objectives To describe the prevalence of unplanned hospitalizations caused by adverse drug reactions ( ADRs ) in older veterans and to examine association between this outcome polypharmacy after controlling for comorbidities other patient characteristics. Design Retrospective cohort. Setting Veterans Affairs Medical Centers. Participants Six hundred seventy‐eight randomly selected (aged ≥ 65) October 1, 2003, September 30, 2006. Measurements Naranjo ADR algorithm, preventability, (0–4, 5–8,...
Myocardial blood flow has been recognized to be heterogeneous in patients with coronary artery disease. Traditional arterial-coronary sinus sampling methods cannot demonstrate comparable heterogeneity of myocardial metabolism. In this study we used a tracer technique investigate possible lactate Twenty-one symptoms ischemic heart disease were studied. We injected 14C-1-lactate intravenously as constant infusion after priming dose. Coronary and arterial samples obtained for chemical...