A5084146413- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Bariatric Surgery and Outcomes
- Obesity and Health Practices
- Body Contouring and Surgery
- Cardiac pacing and defibrillation studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Intensive Care Unit Cognitive Disorders
- Potassium and Related Disorders
- Cardiac electrophysiology and arrhythmias
- Healthcare Decision-Making and Restraints
- Dialysis and Renal Disease Management
- COVID-19 Clinical Research Studies
- Healthcare cost, quality, practices
- Pharmaceutical Economics and Policy
- Health Systems, Economic Evaluations, Quality of Life
- Obesity, Physical Activity, Diet
- SARS-CoV-2 and COVID-19 Research
- Pharmaceutical Practices and Patient Outcomes
- Mechanical Circulatory Support Devices
- Medication Adherence and Compliance
- Cardiac Arrhythmias and Treatments
- Intramuscular injections and effects
Brigham and Women's Hospital
2017-2025
National University Hospital
2021
Northeastern University
2017
Background: Pocket hematoma is a rare complication in patients on anticoagulation after placement of cardiac implantable electronic devices (CIEDs). Current guidance for periprocedural management direct oral anticoagulants (DOACs) varies. Objective: The objective was to report the time before and procedure that DOAC interrupted, compare with guideline best practice, incidence device-related pocket hematoma. Methods: This single-center retrospective chart review admitted CIED insertion or...
Background: There are limited data regarding the incidence of adverse events associated with administering lacosamide by intravenous push (IVP) compared IV piggyback (IVPB). Objective: The objective this analysis was to compare safety profile, including cardiovascular effects, sedative and site reactions IVP IVPB administration. Methods: A retrospective pre/post cohort comparing patients who received via conducted. Safety end points included hypotension, bradycardia, medication-related...
Due to variable pharmacokinetic properties, therapeutic anticoagulation with continuous unfractionated heparin (UFH) requires ongoing laboratory monitoring, generally activated partial thromboplastin time (aPTT). In the ambulatory setting, clinicians who manage warfarin therapy often use in range (TTR) estimate a percentage of international normalized ratio is therapeutic. We applied TTR concept aPTT monitoring for UFH and used 2 methodologies estimation: values (%aIR) modification Rosendaal...
Patients with renal impairment require dose adjustments for direct oral anticoagulants (DOACs), though there is uncertainty regarding their use in severe chronic kidney disease. Inappropriately dosed DOACs may increase risk of ischemic events when under-dosed, or bleeding over-dosed. The purpose this study was to describe DOAC selection, dosing strategies, and associated clinical outcomes patients moderate at our institution. This a single-center retrospective analysis adult outpatients...
Patients initiated on sotalol and dofetilide require inpatient monitoring dose adjustments due to risks of corrected QT (QTc) prolongation Torsades de pointes (TdP). may receive higher initial doses than recommended close by specialized practitioners. The objective this study was describe prescribing practices compare safety outcomes between standard nonstandard dosing strategies.This a single-center retrospective analysis adult inpatients who underwent or initiation June 1, 2015, August...
Abstract Objective The purpose of this study was to determine whether patients who discuss bariatric surgery with their providers are more likely undergo the procedure and lose weight. Methods A retrospective cohort adults BMI ≥ 35 kg/m 2 treated between 2000 2015 conducted analyze relationship a discussion in first year after entry weight changes (primary outcome) receipt (secondary over years entry. Natural language processing used identify documentation electronic provider notes. Results...
Background Diagnosing heparin-induced thrombocytopenia (HIT) in patients with end-stage renal disease (ESRD) can be difficult, as they are frequently exposed to heparin and have multiple etiologies for thrombocytopenia. Objective To correlate 4T scores, IgG heparin–platelet factor 4 (PF4-heparin) ELISA results, serotonin release assay (SRA) results ESRD. Methods We performed a retrospective review of ESRD (creatinine clearance < 15 mL/min or on replacement therapy [RRT]) who underwent...
Abstract Objectives Quantification of direct oral anticoagulant (DOAC) plasma levels can guide clinical management, but insight into scenarios surrounding DOAC-calibrated anti-FXa assays is limited. Methods Apixaban- and rivaroxaban-calibrated chromogenic anti-Xa performed over a 1-year period were retrospectively analyzed. Patient demographics, DOAC history, concomitant medications, renal/liver comorbidities obtained. Indications for testing associated actions reviewed. Machine learning...
Primary care providers are often the first to diagnose chronic kidney disease (CKD).CKD progression is associated with significant morbidity, mortality and cost public healthcare system.Prompt appropriate initial evaluation of CKD, recognition its complications, instituting treatment will delay CKD adverse outcomes.
Metabolic surgery (MS) can lower A1c and achieve DM remission. Counseling by a healthcare provider is an important initial step in considering MS. We hypothesized that MS counseling results significant increase remission improvement. retrospectively studied 3,676 adults aged 18-65 with T2DM, BMI ≥35 kg/m2, ≥6.5% followed at two academic medical centers between 2000-2015, using software tool to identify EMR notes. outcomes were assessed over one three years after study entry, respectively....
IntroductionImplementation of GDMT for HFrEF remains low. We assessed the feasibility a virtual Team optimization during hospitalization non-CV conditions.HypothesisA will improve compared with usual care.MethodsConsecutive hospitalized patients HFrEF≤40% were prospectively identified. Patients critical illness, cardiology consult, de-novo HF, COVID-19 & SBP ≤90mmHg excluded. February 3 to March 1, 2020 served as pre-intervention period which screened, but did not receive interventions. From...