Chani J. Hodonsky
A5018147290- Genetic Associations and Epidemiology
- Atherosclerosis and Cardiovascular Diseases
- Single-cell and spatial transcriptomics
- Blood groups and transfusion
- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- Cardiovascular Health and Risk Factors
- BRCA gene mutations in cancer
- RNA Research and Splicing
- Lipid metabolism and disorders
- Immune cells in cancer
- Bioinformatics and Genomic Networks
- Nuclear Receptors and Signaling
- Tissue Engineering and Regenerative Medicine
- Cardiac Arrest and Resuscitation
- Hemoglobinopathies and Related Disorders
- Genetic factors in colorectal cancer
- Adipokines, Inflammation, and Metabolic Diseases
- RNA modifications and cancer
- Genomics and Rare Diseases
- RNA regulation and disease
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
University of Virginia
2020-2025
Office of Public Health Genomics
2022-2023
University of North Carolina at Chapel Hill
2015-2022
Public Health Department
2016-2019
University of North Carolina Health Care
2015
University of Michigan
2010-2014
Michigan United
2010
Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, genetic populations Hispanic/Latino African ancestry are limited. In addition, these more complex linkage disequilibrium structure. order better define the architecture understudied populations, we leveraged >100,000 phased sequences available from deep-coverage whole genome sequencing through multi-ethnic NHLBI Trans-Omics for Precision Medicine (TOPMed) program impute...
While our understanding of the single-cell gene expression patterns underlying transformation vascular cell types during progression atherosclerosis is rapidly improving, clinical and pathophysiological relevance these changes remains poorly understood.
The atherosclerotic plaque microenvironment is highly complex, and selective agents that modulate stability are not yet available. We sought to develop a scRNA-seq analysis workflow investigate this environment uncover potential therapeutic approaches. designed user-friendly, reproducible will be applicable other disease-specific datasets.Here we incorporated automated cell labeling, pseudotemporal ordering, ligand-receptor evaluation, drug-gene interaction into ready-to-deploy workflow....
Abstract Background The ERBB3 gene is essential for the proper development of neural crest (NC) and its derivative populations such as Schwann cells. As with all cell fate decisions, transcriptional regulatory control plays a significant role in progressive restriction specification NC derived lineages during development. However, little known about sequences mediating regulation or factors that bind them. Results In this study we identified three enhancers at locus evaluated their potential...
Prior GWAS have identified loci associated with red blood cell (RBC) traits in populations of European, African, and Asian ancestry. These studies not included individuals an Amerindian ancestral background, such as Hispanics/Latinos, nor evaluated the full spectrum genomic variation beyond single nucleotide variants. Using a custom genotyping array enriched for content 1000 Genomes imputation, we performed 12,502 participants Hispanic Community Health Study Latinos (HCHS/SOL) hematocrit,...
Circulating white blood cell (WBC) counts (neutrophils, monocytes, lymphocytes, eosinophils, basophils) differ by ethnicity. The genetic factors underlying basal WBC traits in Hispanics/Latinos are unknown. We performed a genome-wide association study of total and differential large, ethnically diverse US population sample ascertained the Hispanic Community Health Study Latinos (HCHS/SOL). demonstrate that several previously known WBC-associated loci (e.g. African Duffy antigen receptor for...
Summary/Abstract Genome-wide association studies (GWAS) have laid the foundation for investigations into biology of complex traits, drug development, and clinical guidelines. However, dominance European-ancestry populations in GWAS creates a biased view role human variation disease, hinders equitable translation genetic associations public health applications. The Population Architecture using Genomics Epidemiology (PAGE) study conducted 26 behavioral phenotypes 49,839 non-European...
Measures of subclinical atherosclerosis, such as coronary artery calcification (CAC) and carotid intima-media thickness (CIMT), reflect the underlying pathophysiology disease (CAD) are genetically correlated with CAD related risk factors. Leveraging summary statistics from genome-wide association studies CAD, CIMT, CAC, type 2 diabetes, low-density lipoprotein cholesterol, systolic blood pressure, we performed 15 separate multi-trait GWAS to identify shared susceptibility loci elucidate...
Abstract Background Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait have been performed in European- or East Asian-ancestry populations, despite evidence that rare ancestry-specific variation contributes substantially to heritability. Recently developed combined-phenotype methods which leverage genetic correlation improve statistical power not yet applied these traits. Here we...
Abstract Observational studies have reported inconsistent associations between bone mineral density (BMD) and coronary artery calcification (CAC). We examined the observational association of BMD with CAC in 2 large population-based evaluated evidence for a potential causal relation using polygenic risk scores (PRS), 1- 2-sample Mendelian randomization (MR) approaches. Our study populations comprised 1414 individuals (mean age 69.9 yr, 52.0% women) from Rotterdam Study 2233 56.5 50.9%...
Single-cell RNA-seq (scRNA-seq) is a powerful genomics technology to interrogate the cellular composition and behaviors of complex systems. While number scRNA-seq datasets available computational analysis tools have grown exponentially, there are limited systematic data sharing strategies allow rapid exploration re-analysis single-cell datasets, particularly in cardiovascular field. We previously introduced PlaqView, an open-source web portal for published atherosclerosis datasets. Now, we...
Polygenic risk scores (PRSs) for coronary artery disease (CAD) potentially improve cardiovascular prediction. However, their relationship with histopathologic features of CAD has never been examined systematically. From 4327 subjects referred to CVPath by the State Maryland Office Chief Medical Examiner sudden death between 1994 and 2015, 2455 cases were randomly selected genotyping. We generated PRS from 291 known loci. Detailed examination arteries was performed in all subjects. The...
Loss-of-function mutations in the Src homology 3 (SH3) domain and tetratricopeptide repeats 2 (SH3TC2) gene cause autosomal recessive demyelinating Charcot–Marie–Tooth neuropathy. The SH3TC2 protein has been implicated promyelination signaling through axonal neuregulin-1 ERBB2 Schwann cell receptor. However, little is known about transcriptional regulation of gene. We performed computational functional analyses that revealed two cis-acting regulatory elements at SH3TC2—one promoter one ∼150...