A5074866754- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- Apelin-related biomedical research
- Single-cell and spatial transcriptomics
- RNA Research and Splicing
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- Lipid metabolism and disorders
- Angiogenesis and VEGF in Cancer
- Genetic Associations and Epidemiology
- Protein Structure and Dynamics
- Computational Drug Discovery Methods
- Medicinal Plant Pharmacodynamics Research
- Hormonal Regulation and Hypertension
- Science, Research, and Medicine
- Ubiquitin and proteasome pathways
- Genetic and phenotypic traits in livestock
- Enzyme Structure and Function
- Neuroinflammation and Neurodegeneration Mechanisms
- Ancient Egypt and Archaeology
- Bioinformatics and Genomic Networks
- Galectins and Cancer Biology
University of Eastern Finland
2017-2025
Kuopio University Hospital
2017
Institute of Bioinformatics and Applied Biotechnology
2012
[Figure: see text].
The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies currently lacking. We developed activity metric and utilized it to conduct pan-cancer oncogenic signaling. identified an immunoevasive phenotype where high associated with low interferon-gamma (IFNγ), HLA-I expression T cell macrophage infiltration squamous the lung, head neck area, cervix esophagus. Squamous overactive tumors comprise molecular...
The Kelch-like ECH-associated protein 1 (KEAP1) - Nuclear factor erythroid 2 -related (NRF2) pathway is the major transcriptional stress response system in cells against oxidative and electrophilic stress. NRF2 frequently constitutively active many cancers, rendering resistant to chemo- radiotherapy. Loss-of-function (LOF) mutations repressor KEAP1 are common non-small cell lung cancer, particularly adenocarcinoma. While can occur throughout gene, they enriched certain areas, indicating that...
Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue functions, preventing efficient fat storage, and thus driving ectopic accumulation into the liver.
Abstract Aims Vascular smooth muscle cells (SMCs) and their derivatives are key contributors to the development of atherosclerosis. However, studying changes in SMC gene expression heterogeneous vascular tissues is challenging due technical limitations high cost associated with current approaches. In this paper, we apply translating ribosome affinity purification sequencing profile SMC-specific directly from tissue. Methods results To facilitate translatome analysis, generated SMCTRAP mice,...
Microarrays and RNA sequencing are widely used to profile transcriptome remodeling during myocardial ischemia. However, the steady-state analysis lacks in sensitivity detect all noncoding species does not provide separation between transcriptional post-transcriptional regulations. Here, we first comprehensive of nascent profiles mRNAs, primary micro-RNAs, long RNAs, enhancer RNAs a large animal model acute infarction.Acute infarction was induced by cardiac catheterization domestic swine....
Background Gene expression profiling of uterus tissue has been performed in various contexts, but a significant amount the data remains underutilized as it is not covered by existing general resources. Methodology/Principal Findings We curated 2254 datasets from 325 related mass scale gene studies on human, mouse, rat, cow and pig species. then computationally derived 'reliability score' for each gene's status (transcribed/dormant), possible combination conditions locations, based extent...
CALCRL (calcitonin receptor-like) protein is an important mediator of the endothelial fluid shear stress response, which associated with genetic risk coronary artery disease. In this study, we functionally characterized noncoding regulatory elements carrying disease that risks single-nucleotide polymorphisms and studied their role in regulation
Hetero dimer (different monomers) interfaces are involved in catalysis and regulation through the formation of interface active sites.This is critical cell molecular biology events.The physical chemical factors determining sites often large numbers.The combined role interacting features frequently combinatorial additive nature.Therefore, it important to determine such interactions.A number have been documented literature since 1975.However, use interaction prediction partners given their...
ABSTRACT Coronary artery disease (CAD) is one of the major causes mortality worldwide. Recent genome-wide association studies have started to unravel genetic architecture disease. Such efforts identified Calcitonin receptor-like (CALCRL), an important mediator endothelial fluid shear stress response, associated with CAD risk variants. In this study we functionally characterized non-coding regulatory elements carrying risks SNPs and studied their role in regulation CALCRL expression cells. We...
Abstract The Kelch-like ECH-associated protein 1 (KEAP1) – Nuclear factor erythroid 2-related 2 (NRF2) pathway is the major transcriptional stress response system in cells against oxidative and electrophilic stress. NRF2 frequently constitutively active many cancers, rendering resistant to chemo- radiotherapy. Loss-of-function (LOF) mutations repressor KEAP1 are common non-small cell lung cancer, particularly adenocarcinoma. While can occur throughout gene, they enriched certain areas,...
Summary The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies currently lacking. We developed robust activity metric and utilized it to conduct pan-cancer wide oncogenic signaling. identified distinct immunoevasive phenotype where high associated with low interferon-gamma (IFNγ), HLA-I expression T-cell infiltration spanning non-small cell lung (NSCLC) squamous head neck area, cervix esophagus. In cancers,...