A5002131258- Sarcoidosis and Beryllium Toxicity Research
- Bacillus and Francisella bacterial research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Monoclonal and Polyclonal Antibodies Research
- Poxvirus research and outbreaks
- Viral Infections and Immunology Research
- T-cell and B-cell Immunology
- Viral Infections and Outbreaks Research
- Single-cell and spatial transcriptomics
- Influenza Virus Research Studies
- Cell Adhesion Molecules Research
- Research on Leishmaniasis Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Cardiomyopathy and Myosin Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genetic Associations and Epidemiology
- Hepatitis B Virus Studies
- Genetics, Aging, and Longevity in Model Organisms
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Ocular Diseases and Behçet’s Syndrome
- Occupational exposure and asthma
- Genomics and Rare Diseases
Oklahoma Medical Research Foundation
2016-2025
University of Oklahoma Health Sciences Center
2011-2025
University of Oklahoma
2023-2024
OU Health
2011-2016
Macquarie University
2014
The University of Sydney
2014
Summary paragraph The Trans-Omics for Precision Medicine (TOPMed) program seeks to elucidate the genetic architecture and disease biology of heart, lung, blood, sleep disorders, with ultimate goal improving diagnosis, treatment, prevention. initial phases focus on whole genome sequencing individuals rich phenotypic data diverse backgrounds. Here, we describe TOPMed goals design as well resources early insights from sequence data. include a variant browser, genotype imputation panel, sharing...
Self-reactive B cells not controlled by receptor editing or clonal deletion may become anergic. We report that fully mature human negative for surface IgM and retaining only IgD are autoreactive functionally attenuated (referred to as naive IgD+IgM− [BND]). These BND typically make up 2.5% of in the peripheral blood, have antibody variable region genes germline (unmutated) configuration, and, all current measures, mature. Analysis 95 recombinant antibodies expressed from single demonstrated...
Among all the body fluids, breast milk is one of richest sources microRNAs (miRNAs). MiRNAs packaged within exosomes are bioavailable to breastfeeding infants. The role miRNAs in determining infant growth and impact maternal overweight/obesity on human (HM) poorly understood. objectives this study were examine select (miR-148a, miR-30b, miR-29a, miR-29b, miR-let-7a miR-32) involved adipogenesis glucose metabolism relationship these with measures composition first 6 months life. Milk samples...
Sarcoidosis is a systemic inflammatory disease characterized by infiltration of immune cells into granulomas. Previous gene expression studies using heterogeneous cell mixtures lack insight cell-type-specific dysregulation. We performed the first single-cell RNA-sequencing study sarcoidosis in peripheral 48 patients and controls. Following unbiased clustering, differentially expressed genes were identified for 18 types bioinformatically assessed function pathway enrichment. Our results...
Purpose: Identify genes associated with ocular sarcoidosis (OS).Methods: We genotyped 1.1 million genetic variants to identify significant OS associations, defined as those that achieved p < 5 × 10-8 in a genome-wide comparison of cases healthy controls our European- or African-American cohorts (EA, AA). Potential functional roles all were assessed.Results: Eight non-HLA found AA compared and confirmed at least suggestive when comparing non-OS cases. Seven these within MAGI1 include...
A characteristic feature of sarcoidosis is a dysregulated immune response to persistent stimuli, often leading the formation non-necrotizing granulomas in various organs. Although genetic susceptibility an essential factor disease development, etiology not fully understood. Specifically, whether autoimmunity contributes initiation or progression uncertain. In this study, we investigated systemic vimentin sarcoidosis. IgG antibodies human were measured sera from patients and healthy controls....
Targeted deletion of TRAF7 revealed that it is a crucial part shear stress-responsive MEKK3-MEK5-ERK5 signaling pathway induced in endothelial cells by blood flow. Similar to Mekk3-, Mek5- or Erk5-deficient mice, Traf7-deficient embryos died utero around midgestation due impaired endothelium integrity. They displayed significantly lower expression transcription factor Klf2, an essential regulator vascular hemodynamic forces downstream the MEKK3-MEK-ERK5 pathway. In addition, Traf7 postnatal...
Myocarditis leads to dilated cardiomyopathy (DCM) with one-third failing recover normal ejection fraction (EF 50%). Our previous studies have supported a Th17 autoimmune pathogenesis where IL17A and IL-6 are elevated in myocarditis patients who do not EF. In the non-recovered group, autoantibody mechanisms of myocardial injury systolic dysfunction fully understood. Furthermore, our cohort, cardiac myosin (CM) autoantibodies (AAbs) were cross-reactive β−adrenergic receptor (βAR). Here we...
Abstract Tuberculosis and sarcoidosis are inflammatory diseases characterized by granulomas that may occur in any organ but often found the lung. The panoply of classical human leukocyte antigen (HLA) alleles associated with occurrence and/or severity both varies considerably across studies. This heterogeneity results, due to variation factors like ancestry disease subphenotype, as well use simple modeling strategies elucidate likely complex relationships, has made conclusions about...
Background Sex differences in the susceptibility of sarcoidosis are unknown. The study aims to identify sex-dependent genetic variations two clinical phenotypes: Löfgren’s syndrome (LS) and non-Löfgren’s (non-LS). Methods A meta-analysis genome-wide association studies was conducted on Europeans African Americans, totaling 10,103 individuals from three population-based cohorts, Sweden ( n = 3,843), Germany 3,342), United States 2,918), followed by an SNP lookup UK Biobank (UKB, 387,945)....
Type I interferons (IFN) causes inflammatory responses to pathogens, and can be elevated in autoimmune diseases such as systemic lupus erythematosus (SLE). We previously reported unexpected associations of increased numbers B lymphocytes expressing the DNA-binding protein ARID3a with both IFN alpha (IFNα) expression disease activity SLE. Here, we determined that IFNα producing low density neutrophils (LDNs) plasmacytoid dendritic cells (pDCs) from SLE patients exhibit strong between...
Understanding immune responses to native antigens in response natural infections can lead improved approaches vaccination. This study sought characterize the humoral anthrax toxin components, capsule and spore individuals (n = 46) from Kayseri Malatya regions of Turkey who had recovered mild or severe forms cutaneous infection, compared regional healthy controls 20). IgG antibodies each component, poly-γ-D-glutamic acid capsule, Bacillus collagen-like protein anthracis (BclA) antigen,...
Meningiomas are the most common primary central nervous system (CNS) tumors in adults, representing approximately one-third of all adult CNS tumors. Although several recent publications have proposed alternative grading systems meningiomas that incorporate genomic and/or epigenomic data to better predict meningioma recurrence and progression-free survival, our understanding driving forces development is still limited.To define gene expression signatures subtypes understand cellular processes...