A5101811389- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Pancreatic and Hepatic Oncology Research
- Virus-based gene therapy research
- Cancer Mechanisms and Therapy
- Hippo pathway signaling and YAP/TAZ
- biodegradable polymer synthesis and properties
- Cancer-related Molecular Pathways
- Polymer Nanocomposites and Properties
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Cell death mechanisms and regulation
- Monoclonal and Polyclonal Antibodies Research
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Pancreatitis Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Viral Infectious Diseases and Gene Expression in Insects
Tongji University
2016-2025
First People’s Hospital of Zunyi
2025
Zunyi Medical University
2025
Shanghai Tenth People's Hospital
2016-2025
Chinese Academy of Sciences
2010-2025
Hainan University
2011-2025
Qingdao University
2020-2025
Affiliated Hospital of Qingdao University
2020-2025
Shanghai East Hospital
2025
South China Botanical Garden
2025
•Liver enzyme abnormalities in patients with COVID-19 are associated disease severity.•Patients liver have higher A-aDO2 and GGT, lower albumin decreased circulating CD4+ T cells B lymphocytes.•SARS-CoV-2 is able to infect the cause conspicuous hepatic cytopathy.•Massive apoptosis binuclear hepatocytes were predominant histological features of SARS-CoV-2-infected liver. Background & AimsLiver common coronavirus 2019 (COVID-19). Whether or not severe acute respiratory syndrome 2 (SARS-CoV-2)...
Immune checkpoint inhibitors (ICIs), including anti-PD-1 therapy, have limited efficacy in patients with microsatellite stable (MSS) colorectal cancer (CRC). Interleukin 17A (IL-17A) activity leads to a protumor microenvironment, dependent on its ability induce the production of inflammatory mediators, mobilize myeloid cells and reshape tumor environment. In present study, we aimed investigate role IL-17A resistance antitumor immunity explore feasibility anti-IL-17A combined therapy MSS CRC...
The protective effects of egg-yolk antibodies obtained from hens immunized with fimbrial antigens a local strain (Escherichia coli K88+ MB, Manitoba, Canada) piliated enterotoxigenic E. (ETEC) were evaluated in 3- and 21-day-old piglets which ETEC diarrhea was induced also early-weaned commercial farm. results demonstrated that the MB-induced 3-day-old cured 24 h after treating while those treated powder conventional continued to have 62.5% them died severe diarrhea. For weaned piglets, fed...
Intracellular accumulation of wild-type tau is a hallmark sporadic Alzheimer's disease (AD), but the molecular mechanisms underlying tau-induced synapse impairment and memory deficit are poorly understood. Here we found that overexpression human full-length (termed hTau) induced deficits with impairments synaptic plasticity. Both in vivo vitro data demonstrated hTau caused remarkable dephosphorylation cAMP response element binding protein (CREB) nuclear fraction. Simultaneously,...
Abstract Background MicroRNAs (miRNAs) are small, non-coding RNAs (20–24 nucleotides) that post-transcriptionally modulate gene expression by negatively regulating the stability or translational efficiency of their target mRNAs. The aim this study was to investigate pattern microRNA-26b (miR-26b) in human breast cancer, and its potential role disease pathogenesis. Methods Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) performed determine level miR-26b 38 cancer...
Breast cancer (BC) is one of the most common malignancies among women worldwide with a high incidence recurrence and metastasis. In this study, we demonstrate that hsa_circ_0068631, circRNA generated from transferrin receptor (TFRC), upregulated in BC tissues cell lines. Knockdown hsa_circ_0068631 inhibited proliferation migration cells vitro vivo. Mechanistically, an RNA pull-down assay immunoprecipitation revealed eukaryotic translation initiation factor 4A3 (EIF4A3) could bind to c-Myc...
Abstract Background Circular RNAs (circRNAs), a novel class of endogenous RNAs, have shown to participate in the development breast cancer (BC). Hsa_circ_0005273 is circRNA generated from several exons PTK2. However, potential functional role hsa_circ_0005273 BC remains largely unknown. Here we aim evaluate BC. Methods The expression level and miR-200a-3p were examined by RT-qPCR tissues cell lines. effect knocking down lines evaluated examinations proliferation, migration cycle. In...
Abstract PI3K/AKT signaling pathway plays an important role in regulating the tumorigenesis, recurrence, and metastasis of breast cancer (BC). In this study, we discovered a circRNA with protein-coding potential, which named circSEMA4B. CircSEMA4B could encode novel protein, SEMA4B-211aa. Both circSEMA4B SEMA4B-211aa were remarkably downregulated BC tissues cell lines. Low expression was positively associated TNM stage, tumor size, lymph node metastasis, distant patients. The functional...
Abstract Background Although numerous studies have indicated that activated pyroptosis can enhance the efficacy of antitumour therapy in several tumours, precise mechanism colorectal cancer (CRC) remains unclear. Methods Pyroptosis CRC cells treated with agents was assessed using various techniques, including Western blotting, lactate dehydrogenase release assay and microscopy analysis. To uncover epigenetic mechanisms regulate NLRP3, chromatin changes NLRP3 promoter histone modifications...
Urolithin A (UA) is a naturally occurring compound that converted from ellagitannin-like precursors in pomegranates and nuts by intestinal flora. Previous studies have found UA exerts tumor-suppressive effects through antitumor cell proliferation promotion of memory T-cell expansion, but its role tumor-associated macrophages remains unknown. Our study aims to reveal how affects tumor cells inhibit breast cancer progression. Observe the effect treatment on progression though vivo vitro...
Dilated cardiomyopathy (DCM) is one of the most common causes heart failure. Infiltration and alterations in non-cardiomyocytes human involve crucially occurrence DCM associated immunotherapeutic approaches. We constructed a single-cell transcriptional atlas normal patients. Then, xCell algorithm, EPIC MCP counter CIBERSORT method were applied to identify DCM-related cell types with high degree precision specificity using RNA-seq datasets. further analyzed heterogeneity among types,...
ABSTRACT Improving the strength and oxidation resistance of natural latex films reducing water‐soluble protein content are essential for preparation high‐quality multifunctional rubber (NRL) products. Hydroxyapatite (HA) has received much attention as a biocompatible material its unique adsorption properties, but poor compatibility with NRL resulted in compromised results. Therefore, this work, HA was modified by dopamine excellent adhesion properties OH NH 2 ‐rich to improve matrix....
Increased evidence reveals that glycolysis is one of the key metabolic hallmarks cancer cells. However, roles lncRNA FTX in energy metabolism and progression remain unclear. In this study we aim to show was significantly upregulated tissues serum CRC patients cell lines. Function indicated it could promote aerobic glycolysis, proliferation, migration invasion colorectal Further mechanistic studies showed, found function as a sponge for miR-215-3p, which reduced ability miR-215-3p repress...
microRNAs are a small class of non-coding RNAs with critical role in the tumorigenesis and maintenance breast cancer through binding to 3'-untranslated regions target mRNAs, which causes block translation and/or mRNA degradation. The purpose this study was investigate expression microRNA-497 (miR-497) as well its potential human cancer. Reverse transcription-polymerase chain reaction (RT-PCR) performed determine pattern miR-497 normal tissues. Correlation analysis conducted characterize...
MicroRNAs (miRNAs) are a small class of non-coding RNAs that widely dysregulated in various cancers. They act as either oncogenes or tumor suppressor genes human cancer. The purpose this study was to examine the expression levels miR-15a breast cancer and its potential role disease pathogenesis. were measured by quantitative polymerase chain reaction (qPCR) 40 specimens adjacent normal tissues. MTT assays, colony formation transwell chamber migration cell cycle apoptosis assays used explore...
MicroRNAs (miRNAs) are a class of highly conserved, small endogenous single-strand non-coding RNAs. They aberrantly expressed in the circulation and tissue patients with cancer. Therefore, it has been suggested that they may act as key regulators carcinogenesis. The aim present study was to examine expression level miR-195-5p human breast cancer its potential role measured 40 specimens adjacent normal tissues by quantitative polymerase chain reaction (qPCR). Next, explore function...