A5101808427- Renal Diseases and Glomerulopathies
- Mathematical Biology Tumor Growth
- Chronic Kidney Disease and Diabetes
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Autoimmune Bullous Skin Diseases
- Dialysis and Renal Disease Management
- Ferroptosis and cancer prognosis
- Renal and Vascular Pathologies
- Lattice Boltzmann Simulation Studies
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Cardiac Fibrosis and Remodeling
- Nutrition and Health in Aging
- Acute Kidney Injury Research
- Central Venous Catheters and Hemodialysis
- Platelet Disorders and Treatments
- Blood properties and coagulation
- Myasthenia Gravis and Thymoma
- MRI in cancer diagnosis
Zunyi Medical University
2025
Chinese PLA General Hospital
2015-2025
Tianjin Medical University Cancer Institute and Hospital
2025
First People’s Hospital of Zunyi
2025
Zhejiang University
2025
Sun Yat-sen University
2016-2025
Stomatology Hospital
2025
University of Chinese Academy of Sciences
2025
Institute of Microbiology
2025
Southern Medical University
2025
Rationale: As a hallmark of various heart diseases, cardiac fibrosis ultimately leads to end-stage failure. Anti-fibrosis is potential therapeutic strategy for Long noncoding RNAs (lncRNAs) have emerged as critical regulators diseases that promise serve targets. However, few lncRNAs been directly implicated in fibrosis. Methods: The lncRNA expression profiles were assessed by microarray fibrotic and remote ventricular tissues mice with myocardial infarction. mechanisms functional...
Abstract Background Established prediction models of Diabetic kidney disease (DKD) are limited to the analysis clinical research data or general population and do not consider hospital visits. Construct a 3-year diabetic risk model in patients with type 2 diabetes mellitus (T2DM) using machine learning, based on electronic medical records (EMR). Methods Data from 816 (585 males) T2DM 3 years follow-up at PLA General Hospital. 46 characteristics that readily available EMR were used develop...
The tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the physiological activities under aerobic conditions. Although tumor metabolic reprogramming places glycolysis in a dominant position, TCA remains indispensable cells as hub linkage and interconversion glucose, lipids, certain amino acids. intermediates such citrate, α-ketoglutarate, succinate, fumarate are altered tumors, they regulate metabolism, signal transduction, immune environment to affect tumorigenesis...
Severe obesity is often associated with inflammation and insulin resistance (IR), which expected to increase the risks of mortality cancers. However, this relationship remains controversial, it's unclear whether healthy lifestyles can mitigate these risks. The independent joint associations severe (body mass index ≥ 35 m/kg2), (C-reactive protein > 10 mg/L systemic markers 9th decile), IR surrogates all-cause all-site cancers, were evaluated in 163,008 participants from UK Biobank cohort....
This study aimed to explore the specific efficacy of rituximab (RTX) in treatment membranous nephropathy (MN) and compare analyze differences effectiveness among various regimens, with objective identifying optimal protocol suitable for medical environment China. retrospective focused on patients MN who were treated RTX hospitalized at First Medical Center PLA General Hospital between January 1, 2019, December 30, 2022. These followed up more than one year. We collected clinical data from...
Multidrug resistance (MDR) of tumor cells is a serious obstacle encountered in cancer treatment. In the current study multiple drug‑resistant HepG2/adriamycin (HepG2/ADR) cell line was established and its MDR characterized. Icaritin, an active ingredient isolated from medical plant Herba Epimedium, observed to reverse present model. Icaritin significantly increased intracellular accumulation ADR decreased expression MDR1 gene HepG2/ADR compared with drug‑sensitive HepG2 cells. addition,...
Abstract Background Frailty and sarcopenia are prevalent in chronic kidney disease (CKD) populations could increase the risk for adverse health outcomes. Few studies assess correlation between frailty, CKD non‐dialysis patients. Therefore, this study aimed to determine frailty‐associated factors elderly stage I–IV patients, expected early identify intervene frailty of Methods A total 774 patients (>60 years age) recruited from 29 clinical centers China March 2017 September 2019 were...
While radiotherapy-induced immunogenic cell death (ICD) holds potential for enhancing cancer immunotherapy, the conventional high-dose irradiation often leads to an immunosuppressive microenvironment and systemic toxicity. Therefore, a biomimetic nanoplatform membrane coated-nitrogen-doped graphene quantum dots combined with Au nanoparticles (C-GAP) was developed in this study. Firstly, homologous traceable targeting features of C-GAP enables tumor-selective accumulation, providing reference...
Increased evidence reveals that glycolysis is one of the key metabolic hallmarks cancer cells. However, roles lncRNA FTX in energy metabolism and progression remain unclear. In this study we aim to show was significantly upregulated tissues serum CRC patients cell lines. Function indicated it could promote aerobic glycolysis, proliferation, migration invasion colorectal Further mechanistic studies showed, found function as a sponge for miR-215-3p, which reduced ability miR-215-3p repress...
Background. Although the clinical importance of immunoglobulin-A nephropathy (IgAN) is widely recognized, characteristics intrarenal arterial lesions in this disease and main factors associated with them have not been studied extensively, a large-scale analysis IgAN has performed. Methods. To clarify these issues, we investigated prevalence, underlying significance 1005 patients IgAN. We distinguished different degrees severity small artery arteriolar (mild, moderate severe), using...
We propose a coupled mathematical modelling system to investigate glioblastoma growth in response dynamic changes chemical and haemodynamic microenvironments caused by pre-existing vessel co-option, remodelling, collapse angiogenesis. A typical tree-like architecture network with different orders for diameter is designed model vasculature host tissue. The substances including oxygen, vascular endothelial factor, extra-cellular matrix degradation enzymes are calculated based on the...
The aim of this study was to analyze the correlation between long noncoding RNA-HOX transcript antisense intergenic RNA (HOTAIR) and clinical pathological characteristics prognosis oral squamous cell carcinoma (OSCC) evaluate effect on growth. HOTAIR expressions in 50 surgically resected samples (including tumor paracancerous tissues) collected from OSCC patients treated our hospital January 2009 December 2010 were detected by real-time quantitative reverse transcription-PCR, relationship...
Patients with triple-negative breast cancer (TNBC) face a major challenge of the poor prognosis, and N6-methyladenosine-(m6A) mediated regulation in has been proposed. Therefore, this study aimed to explore prognostic roles m6A-related long non-coding RNAs (LncRNAs) TNBC.Clinical information expression data TNBC samples were collected from TCGA GEO databases. Pearson correlation, univariate, multivariate Cox regression analysis employed identify independent LncRNAs construct score (PS) risk...
Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide. The clinical spectrum of IgAN varies from minor urinary abnormalities to rapidly progressive renal failure. Evaluation disease by repeated biopsy not practical due its invasive procedure. Urinary sediment miRNAs promise serve as non-invasive biomarkers assess kidney injury IgAN. Fifty two biopsy-proven patients and twenty five healthy controls were enrolled in study. extracted. Expressions miR-34a, miR-205,...
Staphylococcal infection has become a common cause of postinfectious glomerulonephritis in the past 3 decades. Because few investigations focus on this disease, demographics and clinicopathological features related to staphylococcal are not well characterized. We conducted pooled analysis published literature electronic databases analyzed clinical features, laboratory findings, histopathological changes. The patients were divided into 4 groups based their prognosis: remission, persistent...
Abstract Breast cancer is the most commonly diagnosed that affects women worldwide. This study aimed to investigate competing endogenous RNAs (ceRNAs) mechanism in breast cancer. Microarray data were downloaded from University of California Santa Cruz (UCSC) Xena database. The limma package was used screen differentially expressed messenger (DEMs) and long noncoding (DELs). Subsequently, functional analysis performed using DAVID tool. After constructing protein‐protein interaction (PPI)...
IgA nephropathy (IgAN) is one of the most common types glomerulonephritis worldwide and diagnosed only with a renal biopsy. The purpose present studies was to identify potential biomarkers for non-invasive diagnosis IgAN. combination magnetic bead separation system matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) used analyze urinary peptides IgAN patients, other glomerulopathy healthy controls. ClinProTools v.2.0 software also applied establish...
Breast cancer is one of the most lethal malignancies in world. Oxymatrine major effective and toxic alkaloid component which derived from root Sophora flavescens AIT, a traditional Chinese medicine widely distributed Asia Pacific Islands. In current research study, we investigated effects mechanisms action oxymatrine on breast cells. We demonstrated that viability single cell proliferation capability MCF-7 MDA-MB-231, two lines are used vitro were significantly suppressed time-...