A5015896247- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Diabetes Treatment and Management
- Traditional Chinese Medicine Studies
- Ion Transport and Channel Regulation
- Healthcare and Venom Research
- Blood Pressure and Hypertension Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood properties and coagulation
- Lipid metabolism and disorders
- Medicinal Plants and Bioactive Compounds
- Nephrotoxicity and Medicinal Plants
- Biochemical Acid Research Studies
- Cardiac Ischemia and Reperfusion
- Erythropoietin and Anemia Treatment
- Systemic Lupus Erythematosus Research
- Liver Disease Diagnosis and Treatment
- Pharmacology and Obesity Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Hormonal Regulation and Hypertension
- Natural Compound Pharmacology Studies
- Metabolism and Genetic Disorders
- Hepatitis C virus research
Weifang People's Hospital
2025
Second Hospital of Shandong University
2025
Weifang Medical University
2025
State Key Laboratory of Kidney Diseases
2014-2022
Nankai University
2020-2022
Chinese PLA General Hospital
2012-2021
Chinese People's Liberation Army
2014-2021
University of Birmingham
2020
People's Liberation Army No. 150 Hospital
2017
Biogen (United States)
2017
Objectives Thromboembolic events are the major factor affecting prognosis of patients with chronic kidney disease (CKD). Haemostatic alterations possible causes these complications, but their roles remain poorly characterised. In prospective observational study, we investigated entire coagulation process in CKD to elucidate mechanisms high thromboembolic risk. Methods A total 95 and 20 healthy controls who met inclusion criteria were consecutively recruited from September 2015 March 2016....
The accumulation of uremic toxins in chronic kidney disease (CKD) induces inflammation, oxidative stress and endothelial dysfunction, which is a key step atherosclerosis. Accumulating evidence indicates increased mitochondrial fission contributing mechanism for impaired function. Hippurate, toxin, has been reported to be involved cardiovascular diseases. Here, we assessed the toxicity hippurate contribution altered dynamics hippurate-induced dysfunction. Treatment human aortic cells with...
Luteolin is a natural flavonoid exhibiting multiple pharmacological activities. Renal anaemia an important complication of chronic kidney disease (CKD). Whether luteolin can ameliorate renal interstitial fibrosis-induced remains unclear. We examined the therapeutic effects in vitro and vivo models anaemia. After high-throughput sequencing analysis animal samples, we screened differentially expressed genes (DEGs) associated with luteolin-mediated improvements, performed GO KEGG functional...
Abstract Objective The present study was designed to observe the effects of 3,6′-disinapoyl sucrose (DISS), an active oligosaccharide ester component obtained from roots Polygala tenuifolia Willd., on behavioral and biochemical aspects depression induced by chronic mild stress (CMS) in rats. It is first exploration possible association between DISS's antidepressant-like markers depression, involved measuring monoamine oxidase (MAO) activity, cortisol levels, superoxide dismutase (SOD)...
The aims of the present study were to validate differential diagnostic model diabetic nephropathy (DN) and non-diabetic renal diseases (NDRD) established in 2003 establish a new suitable for current clinical characteristics DN. We examined 200 patients with Type 2 diabetes who underwent kidney biopsy from 2004 2012. based on data collected 1993 was evaluated by test changes differentiation parameters DN NDRD analyzed. Logistic regression, receiver operating (ROC) curve, net reclassification...
The Hepatitis B virus infection rate is high in the Chinese population. implications of HBV are widely recognized, and membranous glomerulonephritis most common renal lesion associated with infection. We compared clinicopathologic features 119 HBV-related nephropathy (HBV-MN) 143 idiopathic (IMN) patients to identify those factors that facilitate their discrimination.Cohort analysis demographic information, clinical manifestations, laboratory parameters, pathology prognostic two groups.Most...
Background In China, the prevalence of chronic kidney disease has increased significantly. Many studies shows that spectrum had changed in recent years. We retrospectively analyzed pathological types renal biopsy and its change at General Hospital Chinese People’s Liberation Army from December 1987 to 2012, order offer new supporting evidences for further specifying distribution China. Methods According “Revised Protocol Histological Typing Glomerulopathy” (WHO, 1995), diagnosis was...
Background Systematic lupus erythematosus (SLE) is characterized with various complications which can cause serious organ damage in the human body. Despite significant improvements disease management of SLE patients, non-invasive diagnosis entirely missing. In this study, we used urinary peptidomic biomarkers for early onset to improve patient risk stratification, vital effective drug treatment. Methods Urine samples from patients SLE, nephritis (LN) and healthy controls (HCs) were analyzed...
BACKGROUND Albuminuria has been associated with cardiovascular events, but whether such an association can be explained by endothelial dysfunction is not fully understood. In this study, we examined the relationship between urine albumin-to-creatinine ratio (UACR) and biomarkers of function in patients chronic kidney disease (CKD). MATERIAL AND METHODS The cross-sectional associations renal UACR procoagulant inflammatory factors were evaluated for 151 consecutive CKD (stage 3-5) patients....
Delta large-channel endoscopy and unilateral biportal (UBE) are prominent minimally invasive techniques for treating lumbar spinal stenosis, known minimal tissue damage, clear visualization, quick recovery. However, rigorous controlled research comparing these procedures is scarce, necessitating further investigation into their respective complications long-term effectiveness. This randomized trial aims to compare perioperative outcomes, focusing on postoperative recovery over time. In...
In China, mesangial proliferative glomerulonephritis (MsPGN) is one of the most common kidney diseases. this study, we treated a rat model chronic anti-Thy-1 MsPGN with Shenhua Tablet and evaluated whether tablet was able to protect function. Thirty-six Wistar rats were randomly divided into six groups: (1) Sham surgery (Sham); (2) nephritis (Thy-1); (3) + irbesartan-treated (Irb); (4) low-dose (SHL); (5) medium-dose (SHM); (6) high-dose (SHH). Thirteen weeks after drug treatment, urinary...
BACKGROUND:Contrast-induced nephropathy (CIN) refers to acute renal damage that occurs after the use of contrast agents. This study investigated protective effect probucol in a rat model contrast-induced and mechanism its effect. MATERIAL AND METHODS:Twenty-eight Wistar rats were randomly divided into control group, N-acetylcysteine(NAC) group. We used iopromide-induced CIN. One day prior modeling, received gavage. At 24 h blood biochemistry urine protein assessed. Malondialdehyde (MDA)...
Objective Few studies with large sample populations concerning renal anaemia and IgA nephropathy have been reported worldwide. The purpose of this cross-sectional study was to examine the clinical pathological characteristics influencing factors associated in patients nephropathy, which is most common aetiology chronic kidney disease. Methods A total 462 hospitalised confirmed by biopsy who met inclusion criteria were consecutively recruited from January 2014 2016. Their general information,...
GSE (grape seed extract) has been shown to exhibit protective effects against cardiovascular events and atherosclerosis, although the underlying molecular mechanisms of action are unknown. Herein, we assessed ability enhance eNOS (endothelial nitric oxide synthase) expression NO (nitric oxide) production in H2O2 (hydrogen peroxide)-treated HUVECs (human umbilical vein endothelial cells). enhanced release H2O2-treated cells a dose-dependent manner. inhibited intracellular ROS (reactive oxygen...
Background: Chronic kidney disease (CKD) with moderate-to-severe renal dysfunction usually exhibits an irreversible course, and available treatments for delaying the progression to end-stage are limited. This study aimed assess efficacy safety of traditional Chinese medicine, Niaoduqing particles, in patients stage 3b-4 CKD. Methods: The present was a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial. From May 2013 December 2013, 300 CKD estimated...