A5042718871- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Congenital heart defects research
- RNA modifications and cancer
- Genomic variations and chromosomal abnormalities
- Mesenchymal stem cell research
- Reproductive Biology and Fertility
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Congenital Heart Disease Studies
- Renal and related cancers
- Machine Learning in Bioinformatics
- Prenatal Screening and Diagnostics
- RNA and protein synthesis mechanisms
- Hemostasis and retained surgical items
- Genomics and Rare Diseases
- Connective tissue disorders research
- Genomics and Phylogenetic Studies
- Bone Tissue Engineering Materials
- Tracheal and airway disorders
- Chromosomal and Genetic Variations
- Advances in Cucurbitaceae Research
- Biomedical Text Mining and Ontologies
- Surgical Sutures and Adhesives
- RNA Research and Splicing
Sichuan University
2016-2025
West China Second University Hospital of Sichuan University
2021-2025
State Key Laboratory of Biotherapy
2014-2024
Maternal and Child Health Hospital of Sichuan Province
2016-2023
Chengdu Medical College
2021
Jingzhou Maternal and Child Health Hospital
2019
China Medical University
2004-2015
Northeastern University
2008-2015
Institut thématique Génétique, génomique et bioinformatique
2013
Universidad del Noreste
2012
<h3>AIMS</h3> To determine the prevalence of submicroscopic deletions within chromosome band 22q11 in infants with significant heart disease and compare this other chromosomal abnormalities causing disease. a minimum general population. <h3>METHODS</h3> Chromosome analysis was performed on samples from born former UK Northern Health Region 1994 1995 who either had or were suspected to have deletion following referral Genetics Service. Significant defined as major structural malformation...
Endoscopic submucosal dissection (ESD) for gastrointestinal tumors and premalignant lesions needs fluid cushion (SFC) mucosal uplift before dissection, wound care including closure rapid healing postoperatively. Current SFC materials as well and/or methods post-ESD have single treatment effect hold corresponding drawbacks, such easy dispersion, short duration, weak hemostasis insufficient repair function. Thus, designing that can serve both is highly desired, remains a challenge. Herein, we...
Abstract Rapid and effective control of non‐compressible massive hemorrhage poses a great challenge in first‐aid clinical settings. Herein, biopolymer‐based powder is developed for the hemorrhage. The designed to facilitate rapid hemostasis by its excellent hydrophilicity, specific surface area, adaptability shape wound, enabling it rapidly absorb fluid from wound. Specifically, can undergo sequential cross‐linking based on “click” chemistry Schiff base reaction upon contact with blood,...
Growth hormone (GH) could improve the outcomes of in vitro fertilization and embryo transfer (IVF-ET) patients with decreased ovarian reserve (DOR), but which age group will benefit most has remained controversial. This study aims to explore outcome IVF-ET among differently aged DOR treated GH. A total 846 undergoing from May 2018 June 2023 at Reproductive Medicine Center Sichuan Provincial Women's Children's Hospital were prospectively enrolled. The divided into (< 35 year old, n = 399), B...
Abstract Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic events. It has been shown that the occurrence of calcium oxalate monohydrate (COM) during formation regulated crystal growth modifiers. Although crystallization inhibitors have recognized therapeutic modality for decades, limited progress made in discovery effective modifiers to intervene with disease. In this study, we used metabolomics technologies, powerful approach identify biomarkers...
Copper has been added to scaffolds when investigating bone repair, as an agent promote vascularization; however, little is known concerning its effect on mesenchymal stem cells (MSCs), which are considered be the origin of osteoblasts. In this study, we have aimed elucidate effects copper osteogenic differentiation MSCs.Rat marrow MSCs (rBMSCs) were used a model. Their viability was assessed by MTT assay and Roche's CASY cell counter test calcium deposition evaluated staining with alizarin...
Currently the standard surgical treatment for bladder defects is augmentation cystoplasty with autologous tissues, which has many side effects. Biomaterials such as small intestine submucosa (SIS) can provide an alternative scaffold repair patches. Previous studies have shown that SIS could enhance capacity and compliance of bladder, but its application hindered by issues like limited smooth muscle regeneration stone formation since fast degradation poor mechanical properties SIS....
The recurrence rate for severe intrauterine adhesions is as high 60%, and there still lack of effective prevention treatment. Inspired by the nature uterus, we have developed a bilayer scaffold (ECM-SPS) with biomimetic heterogeneous features extracellular matrix (ECM) microenvironment uterus. As proved subtotal uterine reconstruction experiments, mechanical antiadhesion properties could meet requirement repair. With modification tissue-specific cell-derived ECM, ECM-SPS had ECM signatures...
Abstract Background Growth differentiation factor 9 ( GDF9 ) and bone morphogenetic protein 15 BMP15 genes play important roles in folliculogenesis. Altered expression of the two have been found among patients with poor ovarian response (POR). In this prospective cohort study, we determined follicle fluid (FF) granulosa cells (GCs) derived from responders grouped by age, explored its correlation outcome vitro fertilization embryo transfer (IVF-ET) treatment. Methods A total 196 POR were...
Pancreatic cancer is a serious disease worldwide for its high mortality. Gemcitabine has become the frontline option treatment of this since approval. However, resistance to drug been on rise in recent years. Searching other chemotherapeutic agents therefore attracted much attention. Cucurbitacin B (CuB) member triterpenoid family and shown inhibitory effect various cells. In study, we have assessed CuB pancreatic cells.The growth human cells (PANC-1) was monitored using...