A5089165046- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Gout, Hyperuricemia, Uric Acid
- Occupational and environmental lung diseases
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Renal and related cancers
- Medical Imaging and Pathology Studies
- Muscle and Compartmental Disorders
- Alcohol Consumption and Health Effects
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Mitochondrial Function and Pathology
- Neuroendocrine Tumor Research Advances
- Acute Kidney Injury Research
- Platelet Disorders and Treatments
- Metabolism and Genetic Disorders
- Autophagy in Disease and Therapy
- Dialysis and Renal Disease Management
- Heme Oxygenase-1 and Carbon Monoxide
- Pluripotent Stem Cells Research
- Sarcoma Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Pleural and Pulmonary Diseases
Chinese PLA General Hospital
2015-2025
Baoding People's Hospital
2025
Hainan Medical University
2025
State Key Laboratory of Kidney Diseases
2014-2024
Hainan Medical College Hospital
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Shenzhen University
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Chest Hospital
2024
Guangzhou Medical University
2024
Long non-coding RNA HOTAIR was regarded as an oncogene in multiple cancers. Previous studies have shown that is involved the proliferation and tumorigenesis of renal carcinoma cells, while microRNA (miR)-217 functions a tumor suppressor cell (Rcc). However, underlying molecular mechanism Rcc, especially association with miR-217, has not been studied. In this study, we first demonstrated expression upregulated, which correlated progression, miR-217 downregulated Rcc tissues cells....
The distinction between sarcomatoid mesothelioma and fibrous pleuritis is difficult based on histology, especially when the amount of tumor tissue examined via biopsy small immunohistochemical examination inconclusive. We studied usefulness deletion p16 with fluorescence in situ hybridization (FISH) hypermethylation polymerase chain reaction for diagnosis prognosis malignant pleural (MPM). analyzed 50 MPMs, including 22 cases 10 cases. set cutoff value homozygous pattern as 14.4% FISH...
The mechanism of mesenchymal stem cell therapy in acute kidney injury remains uncertain. Previous studies indicated that cells could attenuate inflammation-related organ by induction regulatory T cells. Whether T-cell is a potential ischemic and how these induced orchestrate local inflammation are unknown. Here we found decrease serum creatinine urea nitrogen levels, improve tubular injury, downregulate IFN-γ production the kidney. In addition to lung, persisted mostly spleen. Mesenchymal...
Abstract No previous case of using fecal microbiota transplantation (FMT) to treat rheumatoid arthritis (RA) has been reported. We report a patient with refractory RA successfully treated FMT indicating that may have good therapeutic effect on RA.
Abstract Ovarian cancer (OC) is the most lethal gynecological carcinoma due to lack of diagnostic markers and effective drug targets. Discovery new therapeutic targets in OC improve treatment outcome urgently needed. We performed proteomic analysis specimens paired normal tissues revealed that proteins associated with mitochondrial proteostasis protein translation were highly expressed ovarian tumor tissues, indicating mitochondria are required for progression OC. Heat shock 60 (HSP60), an...
The aim of the present study was to identify candidate differentially expressed genes (DEGs) and pathways using bioinformatics analysis, improve our understanding cause potential molecular events diabetic nephropathy.Two cohort profile datasets (GSE30528 GSE33744) were integrated used for deep analysis. We sorted DEGs analyzed differential pathway enrichment. DEG-associated ingenuity analysis carried out. screened gene expression feature verified in db/db mouse kidney cortex. Then, rat...
Abstract Clear cell renal carcinoma (ccRCC) is a heterogeneous disease with features that vary by ethnicity. A systematic characterization of the genomic landscape Chinese ccRCC lacking, and associated tumor thrombus (ccRCC-TT) remain poorly understood. Here, we applied whole-exome sequencing on 110 normal-tumor pairs 42 normal-tumor-thrombus triples, transcriptome 61 tumor-normal 30 primary-thrombus from 152 patients ccRCC. Our analysis reveals mutational signature aristolochic acid (AA)...
Uric acid (UA) is an antioxidant found in human serum. However, high UA levels may also have pro-oxidant functions. According to previous research, aldose reductase (AR) plays a vital role the oxidative stress-related complications of diabetes. We sought determine mechanism by which becomes deleterious at concentrations as well effect AR this process.Endothelial cells were divided into three groups cultured without or with 300 μM 600 UA. The total reactive oxygen species (ROS), four ROS...
Background. Although the clinical importance of immunoglobulin-A nephropathy (IgAN) is widely recognized, characteristics intrarenal arterial lesions in this disease and main factors associated with them have not been studied extensively, a large-scale analysis IgAN has performed. Methods. To clarify these issues, we investigated prevalence, underlying significance 1005 patients IgAN. We distinguished different degrees severity small artery arteriolar (mild, moderate severe), using...
Abstract Background Gastric cancer (GC) is the fifth most commonly diagnosed worldwide. Due to dismal prognosis, identifying novel therapeutic targets in GC urgently needed. Evidences have shown that miRNAs played critical roles regulation of tumor initiation and progression. GLI family zinc finger 2 (GLI2) has been reported be up-regulated facilitate progression multiple malignancies. In this study, we focused on GLI2-targeted clarifying underlying mechanism GC. Methods Paired fresh gastric...
IgA nephropathy (IgAN) is a heterogeneous disease, which poses series of challenges to accurate diagnosis and personalized therapy. Herein, we constructed systematic quantitative proteome atlas from 59 IgAN 19 normal control donors. Consensus sub-clustering proteomic profiles divided into three subtypes (IgAN-C1, C2, C3). IgAN-C2 had similar expression patterns with control, while IgAN-C1/C3 exhibited higher level complement activation, more severe mitochondrial injury, significant...
Aging-related changes of tubular cell apoptosis and its mechanisms in renal ischemia/reperfusion (I/R) injury are unclear. In the present study, aged (27-month-old) young (3-month-old) Wistar rats were used to investigate aging-related setting I/R injury. The model was induced by clamping bilateral arteries for 30 minutes followed reperfusion 18 hours. Cyclosporine A (CsA, 2 mg/kg) or mycophenolate mofetil (MMF, 20 mg/kg/d) before ischemia. Age-matched sham-operated served as controls. We...
Connexin 43 (Cx43) plays an important role in cell differentiation and growth control, but whether it can be regulated by high glucose mediate glomerular mesangial cells (GMC) the phenotype alterations that are induced still remain to explored. In this study, RNA interference gene transfer techniques were used knock down overexpress Cx43 rat GMC determine contribution of senescence was glucose. The results show (30 mM) not only downregulated mRNA protein expression (P<0.05) also increased...
Abstract The mortality of rhabdomyolysis-induced AKI remains high because no effective therapy exists. We investigated a new therapeutic method using MSCs. aim this study was to investigate the potential and anti-apoptotic mechanisms action MSCs in treatment induced by glycerol vivo vitro . used Duragen as biological membrane pack on glycerol-injured renal tissue mechanism investigated. In , HK-2 cells were incubated with ferrous myoglobin MSCs-conditioned medium, followed cell proliferation...
Angiogenesis is a critical component of many pathological conditions, and microRNAs (miRNAs) are indispensable in angiogenesis. It unclear whether miRNAs regulate angiogenesis the presence high concentrations uric acid (HUA), underlying mechanisms remain unknown.It was found that HUA inhibited angiogenic ability endothelial cells. miRNA expression profiling conducted using microarray assays HUA-stimulated Eighteen differentially expressed were subjected to bioinformatic analyses. The results...
Background Mesothelioma patients often present with serosal effusions, which are ideal for cytopathological diagnoses. However, the morphological overlap between malignant and benign mesothelial proliferation can make a conclusive cytological diagnosis of mesothelioma elusive because immunohistochemical staining does not discriminate definitively two in this setting. p16 is deleted up to 80% pleural mesotheliomas. The aim study was establish correlation deletion status cell block that its...
Gastric cancer is the second most common malignant tumor in China, ranking third among all mortality rates. Hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to increase significantly effectiveness of chemotherapeutic drugs, prolong action time these drugs on cells, and enhance their diffusion tissues. HIPEC may be one best choices for eradication residual cells abdominal cavity.The aim this study was role preventive after radical gastrectomy.A prospective analysis performed...