A5004435883- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cancer, Stress, Anesthesia, and Immune Response
- Metastasis and carcinoma case studies
- Anesthesia and Neurotoxicity Research
- Neuroendocrine Tumor Research Advances
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal and Anal Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
- Inflammasome and immune disorders
- Neuroblastoma Research and Treatments
- Ubiquitin and proteasome pathways
- Nanoplatforms for cancer theranostics
- Colorectal Cancer Screening and Detection
- Cancer Research and Treatments
- IL-33, ST2, and ILC Pathways
- Ferroptosis and cancer prognosis
- Healthcare Systems and Reforms
- Histone Deacetylase Inhibitors Research
- Biopolymer Synthesis and Applications
Harbin Medical University
2018-2025
Third Affiliated Hospital of Harbin Medical University
2018-2025
Northeast Forestry University
2024
State Forestry and Grassland Administration
2024
Shanxi Medical University
2024
Second Hospital of Shanxi Medical University
2024
Air Force Medical University
2024
Jiangsu University
2022
Xuzhou Cancer Hospital
2022
Mianyang Central Hospital
2020-2021
Abstract Background Lenvatinib is widely used in treatment of unresectable hepatocellular carcinoma (uHCC), but the benefit its combination with immunotherapy needs to be verified. This study evaluated efficacy and safety tislelizumab plus lenvatinib systemic treatment-naïve patients uHCC. Methods In this multicenter, single-arm, phase 2 study, uHCC received 200 mg every three weeks (bodyweight ≥ 60 kg: 12 mg; < 8 once daily). Dose-limiting toxicities (DLTs) were run-in determine whether...
Abstract Background Although numerous studies have indicated that activated pyroptosis can enhance the efficacy of antitumour therapy in several tumours, precise mechanism colorectal cancer (CRC) remains unclear. Methods Pyroptosis CRC cells treated with agents was assessed using various techniques, including Western blotting, lactate dehydrogenase release assay and microscopy analysis. To uncover epigenetic mechanisms regulate NLRP3, chromatin changes NLRP3 promoter histone modifications...
Background The programmed death 1 inhibitor toripalimab plus the angio-immuno kinase surufatinib revealed a tolerable safety profile and preliminary efficacy in patients with advanced solid tumours phase I study. Patients methods This was an open-label, single-arm, multi-cohort II study China. neuroendocrine (NETs) or carcinomas (NECs) mixed non-neuroendocrine neoplasms (MiNENs) who had failed were intolerable of standard treatment given (250 mg orally, once daily) (240 intravenously, every...
In recent years, a growing number of clinical studies have shown that immune checkpoint inhibitor (ICI) can increase the remission rate and improve prognosis patients with esophageal cancer. The Controlling Nutritional Status (CONUT) score is novel nutritional indicator predict certain malignancies. We retrospectively analyzed data 69 advanced cancer treated ICI assessed relationship between clinicopathological factors including CONUT score, systemic immune-inflammatory index (SII),...
The clinical role of deficient DNA mismatch repair (dMMR)/microsatellite instability-high (MSI-H) in gastric cancer (GC) is still controversial. We aimed to analyze the relationship between dMMR/MSI-H and clinicopathological features along with survival.Patients who were diagnosed GC at three big centers China from 2015 2020 evaluated retrospectively. MMR/MSI status was assessed using immunohistochemistry/PCR. Clinical pathological data collected medical record system.A total 196 patients...
Abstract Background Neoadjuvant immunochemotherapy (NICT) plus esophagectomy has emerged as a promising treatment option for locally advanced esophageal squamous cell carcinoma (LA-ESCC). Pathologic complete response (pCR) is key indicator associated with great efficacy and overall survival (OS). However, there are insufficient indicators the reliable assessment of pCR. Methods 192 patients LA-ESCC treated NICT from December 2019 to October 2023 were recruited. According pCR status,...
<title>Abstract</title> Background The rapid aging of the global population has intensified chronic disease burdens, widened healthcare access disparities, and increased unmet care needs. Internet‑based services (IHS) offer a potential solution to these challenges. This study assessed prevalence IHS use, its key determinants, main motivations barriers among adults aged ≥ 50 years in mainland China. Methods An online survey China was conducted March 2021. Participants (N = 500) were recruited...
Metallosilicates, represented by TS-1 titanosilicate, have brought revolutionary green upgrades in the production of bulk chemicals fabricating efficient selective oxidation catalytic systems since 1980s. The restrictions derived from the...
Although the TNM staging system plays a critical role in guiding adjuvant chemotherapy for colorectal cancer (CRC), its precision risk stratification stage II and III CRC patients with proficient DNA mismatch repair (pMMR) remains limited. Therefore, precise predictive models research on postoperative treatments are crucial enhancing patient survival improving quality of life. This retrospective study analyzed 1051 pMMR who underwent radical resection were randomly assigned to training (n =...
Purpose: Ubiquitin specific peptidase 5 (USP5) has been reported to promote the progression of several malignant tumors.It may affect cancer development via modulating cell cycle and colony formation.In pancreatic cancer, biological function USP5, especially in migration invasion remains unclear.Methods: USP5 protein expression levels primary lymph node metastasis tissues were detected using immunohistochemistry (IHC).χ 2 test, Kaplan-Meier analysis, univariate multivariate analyses used...
To investigate the diagnostic performance of ADNEX model in International Ovarian Tumor Analysis models for ovarian tumors and further explore its application value staging tumors.A total 224 patients who underwent ultrasound evaluation adnexal masses were treated surgically owing to from January 2018 June 2020 our hospital selected research on accuracy model. The clinical information ultrasonographic findings collected, pathological diagnosis was taken as gold standard. According model,...
4115 Background: PD-1 inhibitor with Lenvatinib were reported to improve ORR in patients metastatic HCC. KN046 was a bispecific antibody that target both PD-1/PD-L1 and CTLA-4/B7 immune checkpoints pathway. Preliminary report already showed good efficacy tolerable safety of the KN046+Lenvatinib regimen. Here we updated results more enrolled longer follow-up duration. Methods: This is an open-label, single-arm, multicenter, phase II trial pts unresectable or Enrolled (pts) Barcelona Clinic...
Novel biomarkers are essential to improve the treatment efficacy and overall survival of stage II III colorectal cancer (CRC), allowing for personalized decisions. Here, densities CD8+ FOXP3+ T cells in tumor invasive margin were processed by immunohistochemistry digital pathology form a scoring system named regulatory-Immunoscore (RIS). Cox proportional hazards regression models used determine risk factors associated with time recurrence. Harrell's concordance index time-dependent area...
4138 Background: Pancreatic ductal adenocarcinoma（PDAC）is one of the most lethal malignancies worldwide and is characterized by extremely poor prognosis. Nab-paclitaxel plus gemcitabine has been recommended international guidelines for first-line treatment advanced PDAC but chemoresistance difficult to avoid. Combination immune checkpoint inhibitors (ICIs) chemotherapy demonstrated substantial promise several malignancies. A few recent studies have begun explore effect ICIs monotherapy or co...
e16199 Background: Patients with advanced neuroendocrine carcinoma (NEC) have a poor prognosis and limited treatment option after first-line treatment. Surufatinib, multi-kinase inhibitor of VEGFR 1-3, FGFR 1 CSF-1R, has been approved in patients or metastatic extra-pancreatic tumors China. Toripalimab is monoclonal humanized IgG4 PD-1 antibody. Surufatinib modulates tumor immune microenvironment shown promising antitumor activity combination toripalimab solid tumors, including carcinoma....
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Inflammatory markers have been confirmed to be associated with the prognosis of cancer patients. In this study, we compared impacts intravenous anesthesia and inhalation on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), systemic immune-inflammation index (SII) after esophageal surgery. We retrospectively reviewed electronic medical records patients who underwent esophagectomy from January 1, 2014 December 31, 2016. Patients respectively received total (TIVA) or...
Abstract Circulating tumor cells (CTCs) indicate the diagnosis and prognosis of cancer patients, together with benefiting individual treatment anticancer drug development. However, their large‐scale application in general population still requires systematically multifaceted modifications for currently proprietary new technologies based on filtration. We primitively utilized a cell size‐based platform to evaluate recovery efficiency spiked abnormal lines analyzed circulating (CACs). To...
Different types of anesthesia may affect cancer patient's outcomes, we compared the overall survival (OS) and disease-free (DFS) patients with pancreatic under total intravenous inhalation anesthesia.The authors collected electronic medical records who had accepted at a pancreatectomy from January 1, 2010 to December 31, 2016. Patients respectively received (TIVA) or inhalational (INHA). Stabilized inverse probability treatment weighting (SIPTW)was used minimize differences. Kaplan-Meier was...
Abstract Background Different anesthetics may have opposite effects on the immune system, thus affecting prognosis of tumor patients. Cell-mediated immunity forms primary defense against invasion cells, so manipulation system to produce an enhanced anti-tumor response could be utilized as adjuvant oncological therapy. Sevoflurane has proinflammatory effects, while propofol, anti-inflammatory and antioxidant effects. Therefore, we compared overall survival (OS) disease-free (DFS) patients...
Non-Hodgkin's intravascular large B-cell lymphoma is a highly invasive extranodal lymphoma. The proliferating tumor cells invade the small vessels and capillaries of different organs. clinical symptoms are atypical, there lack specificity, molecular biological behaviors not clear, thus, present study aimed to improve current understanding non-Hodgkin's (IVL) provide an accurate basis for treatment prognosis, by retrospectively analyzing summarizing clinicopathological features,...
We aimed to explore whether the prognosis of patients treated with capecitabine and oxaliplatin (XELOX) or S-1 (SOX) regimens who received fewer cycles chemotherapy after D2 radical resection for gastric cancer (GC) would be non-inferior that standard number chemotherapy.Data on XELOX SOX undergoing at Harbin Medical University Cancer Hospital between January 2011 May 2016 were collected.In 4, 6, 8 chemotherapy, 5-year overall survival (OS) rates 59.4%, 64.8%, 62.7%, respectively. Compared 4...
Abstract Background Colorectal cancer is one of the most common cancers in world. Several studies suggest using Asia-Pacific colorectal screening (APCS) score and its modified versions to select high-risk populations for early colonoscopy, but external validation remains rare, which should be selected CRC China unclear. Validation multiple scores same population might help choose best performing score. Methods We conducted a cross-sectional study under framework Cancer Screening Program...
To compare the efficacy of adjuvant chemotherapy with six or eight cycles S-1 plus oxaliplatin (SOX) Capecitabine (XELOX) after D2 resection GC.We collected 470 cases patients TNM stage II and III GC who underwent gastrectomy in Harbin Medical University Cancer Hospital from January 2007 to December 2017 received SOX XELOX regimen. This study was designed evaluate prognosis receiving identify appropriate number cycles.Among participants [340 (72.3%) males; median age, 50 years (range, 24-76...