A5056314971- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Disaster Response and Management
- Viral Infections and Vectors
- Liver Disease and Transplantation
- Malaria Research and Control
- Mosquito-borne diseases and control
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Viral gastroenteritis research and epidemiology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cardiac tumors and thrombi
- Optimism, Hope, and Well-being
- Machine Learning in Bioinformatics
- Enhanced Recovery After Surgery
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- Heat shock proteins research
- Neutropenia and Cancer Infections
Chinese People's Liberation Army
2024
Chinese PLA General Hospital
2019-2023
Intensive Care Society
2020
Yale University
2020
302 Military Hospital of China
2010-2018
Zero to Three
2012
•Liver enzyme abnormalities in patients with COVID-19 are associated disease severity.•Patients liver have higher A-aDO2 and GGT, lower albumin decreased circulating CD4+ T cells B lymphocytes.•SARS-CoV-2 is able to infect the cause conspicuous hepatic cytopathy.•Massive apoptosis binuclear hepatocytes were predominant histological features of SARS-CoV-2-infected liver. Background & AimsLiver common coronavirus 2019 (COVID-19). Whether or not severe acute respiratory syndrome 2 (SARS-CoV-2)...
BACKGROUND. Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), has become a pandemic. This study addresses the clinical and immunopathological characteristics of COVID-19.
During 2014-2015, an outbreak of Ebola virus disease (EVD) swept across parts West Africa. No approved antiviral drugs are available for treatment currently. A retrospective clinical case series was performed EVD patients in Sierra Leone-China Friendship Hospital. Patients with confirmed were sequentially enrolled and treated either World Health Organization (WHO)-recommended supportive therapy (control group) from 10 to 30 October, or WHO-recommended plus favipiravir (T-705) 1 November...
A Chinese medical team managed Ebola virus disease (EVD) patients in Sierra Leone from October 2014 to March 2015 and attended 693 suspected patients, of whom 288 had confirmed disease.A retrospective study was conducted the with disease. Clinical symptoms, manifestations, serum viral load were analyzed compared among different groups for mortality survival time.Among EVD (149 male 139 female, median age 28 years, log 6.68), 98 died, 36 recovered, 154 lost follow-up. Common symptoms fever...
Cytokine storm has been reported in patients with coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. We examine the incidence of on chronic liver failure (ACLF) COVID-19 pre-existing compensated (CLD).From 20 Jan 2020 7 Feb 2020, we studied 140 consecutive admitted either Fuyang Second People's Hospital (FYSPH), Anhui or Fifth Medical Center Chinese PLA General (PLAGH) Beijing, China. Pre-existing CLD includes those cirrhosis...
Abstract To describe the epidemiological and clinical characteristics of patients with Corona Virus Disease 2019 (COVID-19) in Beijing. analyze application corticosteroids severe pneumonia. We collected information on demographic characteristics, exposure history, use, outcomes 65 confirmed cases COVID-19 at Fifth Medical Center PLA General Hospital from Jan 20 to Feb 23, 2020. The final follow-up date observed was April 15th, number mild, general, severe, critical type were 10 (15.38%), 32...
Hepatocellular carcinoma (HCC) is a prevalent cancer in China, with chronic hepatitis B (CHB) and liver cirrhosis (LC) being high-risk factors for developing HCC. Here, we determined the serum proteomes (762 proteins) of 125 healthy controls Hepatitis virus-infected CHB, LC, HCC patients constructed first cancerous trajectory diseases. The results not only reveal that majority altered biological processes were involved hallmarks (inflammation, metastasis, metabolism, vasculature,...
Citrobacter rodentium (C. rodentium) infection is a widely used murine model to mimic human enteric bacteria and inflammatory bowel disease (IBD). In this model, interleukin (IL)‑17A plays critical roles in increasing chemokine cytokine production various tissues recruit innate cells, including monocytes neutrophils, the local site of infection. However, source IL‑17A remains unclear, as majority cell types produce IL‑17A, intestinal endothelium immune cells CD4+ T development. current...
Abstract Hepatocellular carcinoma (HCC) is the fifth most common malignant cancer in world. The sensitivity of alpha-fetoprotein (AFP) still inadequate for HCC diagnosis. Tissue interstitial fluid (TIF), as liquid microenvironment cells, was used biomarker discovery this study. Paired tumor and nontumor TIF samples from 6 HBV-HCC patients were analyzed by a proteomic technique named iTRAQ (isobaric tag relative absolute quantitation). Totally, 241 up-regulated proteins (ratio ≥ 1.3, p <...
Abstract Four and a half LIM domain (FHL) proteins belong to family of LIM‐only that have been implicated in the development progression various types cancers. However, role FHL tumor angiogenesis remains be elucidated. Herein, we demonstrate FHL1‐3 decrease promoter activity expression vascular endothelial growth factor (VEGF), key regulator cancer as well an important target gene transcription hypoxia‐inducible 1 (HIF1α/HIF1β). interacted with HIF1α both vitro vivo . A single FHL1 was...
Abstract Background& Aims The Coronavirus Disease 2019 (COVID-19) has become a global epidemic and caused lasting huge loss of life security, economic development social stability in more than 180 countries around the world. Unfortunately, there is still no specific treatment for COVID-19 till now, therefore, at this point, all potential therapies need to be critically considered. LL-37 one best-studied human antimicrobial peptide (AMPs) that broad-spectrum activity against bacteria...
Abstract The aim of this study was to determine whether mutations in the hepatitis B virus (HBV) genome are associated with onset acute on chronic liver failure (ACLF). For longitudinal study, full‐length HBV genomes were cloned and sequenced from four ACLF patients compared sequences matching samples collected before ACLF. cross‐sectional 166 serum obtained, including 49 results showed that C53T, A1846T, G1896A most common association In 61.2% presented T1846, which higher than (CHB)...
BACKGROUND Hepatocellular carcinoma (HCC) is a prevalent and aggressive tumor. Sorafenib the first-line treatment for patients with advanced HCC, but resistance to sorafenib has become significant challenge in this therapy. Cancer stem cells play crucial role HCC. Our previous study revealed that long non-coding RNA (lncRNA) KIF9-AS1 an oncogenic gene However, of drug cancer stemness HCC remains unclear. Herein, we aimed investigate function mechanism lncRNA AIM To describe elucidate...
Objective: The present study aims to investigate the cytokines interleukin (IL)-4, IL-6, IL-10, and IL-17 in peripheral blood of patients with acute-on-chronic liver failure combined sepsis, failure, cirrhosis; changes levels inflammatory factors cases coagulation dysfunction sepsis; discover more typical for further evaluation by functional experiments. Methods: In study, 41 sepsis were enrolled as subjects. These compared 20 either cirrhosis during same period. IL-4, detected each group...
Abstract We aimed to develop a prediction model based on the PIRO concept (Predisposition, Injury, Response and Organ failure) for patients with Hepatitis B Virus (HBV) related acute-on-chronic liver failure (ACLF). 774 HBV ACLF defined in CANONIC study were analyzed according components. Variables associated mortality selected into model. Based regression coefficients, score each component was developed, classification tree used stratify different nodes. The then validated using an...
Serum lactate (LA) and dehydrogenase (LDH) levels have a major impact on the clinical treatment of malignant tumors critically ill patients. Nevertheless, assessment disease severity in oncology patients admitted to intensive care unit (ICU) remains incomplete when considering serum LA LDH levels. This study aimed investigate significance assessing predicting outcomes with colorectal cancer (CRC) ICU.
Objective. This study was aimed at clarifying the application effect of silicone mattress combined with hydrocolloid dressing in ICU patients liver failure. Methods. A total 86 failure admitted to intensive care unit (ICU) Fifth Medical Center Chinese PLA General Hospital from September 2018 2020 were selected as research subjects. Patients treated conventional sponge and routine nursing included group ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>n</mi> <mo>=</mo>...
To investigate the predictive value of blood ammonia (BLA) quantification in prognosis acute liver failure (ALF).Seventy-one patients with ALF were enrolled and BLA concentration was measured all patients. After following up for 28 days, divided into two groups: surviving group (n = 21) deceased 50). An independent-samples t-test used to compare concentrations between groups, receiver operating characteristic curves ¬evaluate ALF. A fourfold table analysis performed determined cutoff...