A5103271179- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Influenza Virus Research Studies
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Long-Term Effects of COVID-19
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Systemic Lupus Erythematosus Research
- Bacteriophages and microbial interactions
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Extracellular vesicles in disease
- COVID-19 diagnosis using AI
- Ferroptosis and cancer prognosis
- COVID-19 epidemiological studies
Chinese PLA General Hospital
2019-2025
Chinese People's Liberation Army
2021-2023
Institute of Microbiology
2021
Fujian Medical University
2021
Chinese General Hospital College of Nursing and Liberal Arts
2020-2021
PLA 306 Hospital
2002-2020
Institute of Clinical Research
2020
State Council of the People's Republic of China
2020
302 Military Hospital of China
2004-2018
Second Military Medical University
2018
BACKGROUND. Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), has become a pandemic. This study addresses the clinical and immunopathological characteristics of COVID-19.
Hepatocellular carcinoma (HCC) is one of the greatest life threats for Chinese people, and prognosis this malignancy poor due to strong chemotherapy resistance in patients. Notch pathway components mediate cell survival epithelial-mesenchymal transition (EMT), also participate induction multi-drug (MDR). In present study, we demonstrated discovery a novel inhibitor activating/cleaving enzyme ADAM-17, named ZLDI-8; it inhibited cleavage NOTCH protein, consequently decreased expression...
The pregnane X receptor (PXR) mediates the resistance of sorafenib in hepatocellular carcinoma (HCC) by promoting clearance or elimination <italic>via</italic> drug resistance-related downstream genes PXR. Rhamnetin drepresses activation PXR miR-148a.
Our previous study identified AKT1, AKT2 and AKT3 as unfavorable prognostic factors for patients with hepatocellular carcinoma (HCC). However, limited data are available on their exact mechanisms in HCC. Since microRNAs (miRNAs) implicated various human cancers including HCC, we aimed to screen miRNAs targeting AKTs investigate underlying HCC by integrating bioinformatics prediction, network analysis, functional assay clinical validation. Five online programs of miRNA target prediction...
Pregnane X receptor (PXR), which is a member of the nuclear protein family (nuclear subfamily 1 group I 2 [NR 1I2]), mediates drug-resistance in hepatocellular carcinoma (HCC) via enhancing expression drug-resistance-related genes accelerate clearance antitumor drugs, eg, sorafenib. However, there are few reports on miRNA targeting PXR participating epigenetic regulation HCC cells.TargetScan 7.2, an online method, was used to predict miRNAs potentially PXR. The and downstream detected by...
BackgroundThe clinical management of coronavirus disease 2019 (COVID-19) is dependent on understanding the underlying factors that contribute to severity. In absence effective antiviral therapies, other host immunomodulatory therapies such as targeting inflammatory response are currently being used without clear evidence their effectiveness. Because inflammation an essential component mechanisms, may adversely affect viral clearance and outcome.ObjectiveTo understand whether persistent...
The pregnane X receptor (PXR) is an important regulator of hepatocellular carcinoma cellular resistance to antitumor drugs. Activation PXR was modulated by the co-regulators. target protein for Xenopus plus end-directed kinesin-like (Xklp2) known as TPX2 that previously considered a tubulin regulator, also functions some transcription factors and pro-oncogenes in human malignances. However, actions on HCC cells are still unclear. In present study, our results demonstrate high expression...
Although molecular-targeted agents are still the first choice for advanced hepatocellular carcinoma (HCC) treatment, therapeutic efficacy of these is not satisfactory. Recently, mammalian target rapamycin (mTOR) considered to be a promising molecular that can enhance sensitivity HCC cells antitumor therapy. However, reported mTOR inhibitors have some shortcomings, and novel need developed effect molecularly targeted on HCC.In this study, five small-molecular compounds could serve as...
BackgroundWhether achieving sustained virological response (SVR) in patients with hepatitis C attains complete elimination of virus (HCV) is unknown, because occult HCV infection (OCI), defined as the detection HCV-RNA hepatocytes or peripheral blood mononuclear cells (PBMC) absence serum HCV-RNA, may occur. We thus investigated prevalence and clinical relevance OCI.MethodsSubjects from three hospitals who had achieved clearance, including 60 Direct-acting antiviral agents (DAAs) induced...
MicroRNAs (miRNAs) contribute to a wide variety of human diseases by regulating gene expression, leading imbalances in regulatory networks. To discover novel hepatocellular carcinoma (HCC)-related miRNA-target axes and elucidate their functions, we here performed systematic investigation combining biological data acquisition integration, prediction, network construction, functional assay clinical validation. As result, total 117 HCC differentially expressed miRNAs were identified, 728 high...
Forty-five KPC-producing Enterobacteriaceae strains were isolated from multiple departments in a Chinese public hospital 2014 to 2015. Genome sequencing of four representative strains, namely Proteus mirabilis GN2, Serratia marcescens GN26, Morganella morganii GN28, and Klebsiella aerogenes E20, indicated the presence blaKPC-2-carrying IncX6 plasmids pGN2-KPC, pGN26-KPC, pGN28-KPC, pE20-KPC respectively. These genetically closely related one another only previously sequenced plasmid,...
Increasing evidence has shown that the metabolism and clearance of molecular targeted agents, such as sorafenib, plays an important role in mediating resistance HCC cells to these agents. Metabolism sorafenib is performed by oxidative metabolism, which initially mediated CYP3A4. Thus, targeting CYP3A4 a promising approach enhance sensitivity chemotherapeutic In present work, we examined association between prognosis patients receiving sorafenib. Using online tool miRDB, predicted...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is difficult to detect early and highly aggressive, often leading poor patient prognosis. Existing serum biomarkers like CA19-9 are limited in diagnosis, failing meet clinical needs. Machine learning (ML)/deep (DL) technologies have shown great potential biomedicine. This study aims establish PDAC differential diagnosis prognosis assessment models using ML combined with for risk stratification, personalized treatment...
AIM:To investigate the prevalence of autoantibodies and their associations with clinical features in Chinese patients chronic hepatitis B (CHB). METHODS:A total 325 CHB were enrolled this retrospective, hospitalbased study.Patients C (CHC), autoimmune (AIH), or primary biliary cirrhosis (PBC) included, healthy donors acting as controls.A panel that serologically define AIH PBC was tested by indirect immunofluorescence assay line immunoassay.The AIH-related autoantibody profile included...
Abstract Background Current chemotherapy for acute myeloid leukemia (AML) mainly involves cytotoxic agents such as doxorubicin (DNR), mitoxantrone (Mito) or 2‐aminopurine‐6‐thiol (6‐TG). However, because these are relatively ineffective, discovering other more effective drugs AML treatment would be valuable. Methods The in vitro antitumor effect of lenvatinib on cells was examined using the colorimetric MTT assay assessing cell metabolic activity. mixed with Poloxamer 407 were injected into...
More than 70% of hepatocellular carcinoma (HCC) cases develop as a consequence liver cirrhosis (LC). Here we have evaluated the diagnostic potential four serum biomarkers, and developed models for HCC diagnosis differentiation from LC patients. Serum levels α-fetoprotein (AFP), AFP-L3, des-γ-carboxy prothrombin (DCP), Golgi protein 73 (GP73) were analyzed in 114 advanced patients, 81 early stage 152 Multilayer perceptron (MLP) radial basis function (RBF) neural networks used to construct...
The early prediction values of diagnostic markers for hepatocellular carcinoma (HCC) are still unclear at present. This study evaluated the value ten serum in HCC. A total 109 cases hepatic cirrhosis patients were followed up 36 months and relationship between lifetime risk developing HCC levels was analyzed. 31.2 (34/109) percent developed during study’s timeframe. Higher alpha-fetoprotein (AFP), alpha-fetoprotein-L3 (AFP-L3), alanine aminotransferase (ALT), AFP-L3/AFP ratio potential...
Background: An outbreak of severe respiratory illness caused by a novel coronaviruses (2019- nCoV) in China since December 2019. This work aim to evaluate the clinical diagnostic values Immunoglobulin G/M's or inflammatory-related factor's level patients' serum sample and relationship with manifestations epidemiologic features. Methods: A total forty-nine patients confirmed nucleic acid test were enrolled this study, S (Spike) N (Nucleocapsid) -based G/M neutralizing antibodies detected 206...
The MDM2 binding protein (MTBP) has been considered an important regulator of human malignancies. In this study, we demonstrate that the high level MTBP’s endogenous expression is correlated with poor prognosis advanced hepatocellular carcinoma (HCC) patients who received sorafenib. MTBP interacted Pregnane X receptor (PXR) and enhanced transcription factor activity PXR. Moreover, accumulation PXR in HCC cells’ nuclear recruitment to its downstream gene’s ( cyp3a4’s ) promoter region....