A5101864857- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Renin-Angiotensin System Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Aortic Disease and Treatment Approaches
- Cancer, Lipids, and Metabolism
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- Nitric Oxide and Endothelin Effects
- Aortic aneurysm repair treatments
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Heat Transfer and Optimization
- Pancreatic and Hepatic Oncology Research
- Telomeres, Telomerase, and Senescence
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Heat Transfer and Boiling Studies
- Hypothalamic control of reproductive hormones
- Cancer, Hypoxia, and Metabolism
Shandong University of Traditional Chinese Medicine
2015-2025
Guangdong Provincial People's Hospital
2025
Chongqing Medical University
2022-2025
Tianjin Medical University Cancer Institute and Hospital
2025
Nara Medical University
2013-2024
Huazhong University of Science and Technology
2016-2024
Lanzhou University
2021-2024
Lanzhou Veterinary Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Zhejiang University
2013-2024
Background Ischemic stroke is the main cause of disability worldwide, leading to a serious socioeconomic burden. Ferroptosis non-apoptotic form programmed cell death and related various diseases. Acyl-CoA synthetase long-chain family member 4 (ACSL4) considered target ferroptosis, but its specific role in ischemic remains unclear. In this study, we investigate whether inhibition ACSL4 promotes recovery neurological function way that prevents ferroptosis. Methods A transient cerebral ischemia...
Chimeric antigen receptor T (CAR-T) cell therapy has shown promising results for relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL). The immune response induced by murine single-chain variable fragment (scFv) of the CAR may limit CAR-T persistence and thus increases risk relapse. In this study, we developed a novel humanized scFv from FMC63 antibody. A total 18 R/R ALL patients with or without prior CD19 were treated CD19-targeted cells (hCART19s). After lymphodepletion...
Abstract Objective Increasing evidence has revealed that mechanical stress and elevated signals promote malignant tumor transformation metastasis. This study aimed to explore the function of mechanically activated ion-channel Piezo1 in colon cancer metastasis its potential regulatory mechanism. Methods First, we examined expression levels mitochondrial calcium uniporter (MCU) both tissues assessed prognostic value MCU a cohort ( n = 110). Second, functional assays were performed investigate...
Abstract The Cri du Chat Syndrome (CdCS), a devastating genetic disorder caused by deletion on chromosome 5p, faces challenges in finding effective treatments and accurate animal models. Using CRISPR‐Cas9, novel CdCS rat model with 2q22 is developed, mirroring common alteration patients. This exhibits pronounced deficits social behavior, cognition, anxiety, accompanied neuronal abnormalities immune dysregulation key brain regions such as the hippocampus medial prefrontal cortex (mPFC)....
Cellular dedifferentiation is the major process underlying totipotency, regeneration, and formation of new stem cell lineages in multicellular organisms. In animals it often associated with carcinogenesis. Here, we used tobacco protoplasts (plant cells devoid wall) to study changes chromatin structure course mesophyll cells. Using flow cytometry micrococcal nuclease analyses, identified two phases decondensation prior entry into S phase. The first phase takes place protoplast isolation,...
Angiotensin II (Ang II) is a main pathophysiological culprit peptide for hypertension and atherosclerosis by causing vascular smooth muscle cell (VSMC) proliferation migration. Exendin-4, glucagon-like peptide-1 (GLP-1) receptor agonist, currently used the treatment of type-2 diabetes, believed to have beneficial effects cardiovascular diseases. However, protective mechanisms GLP-1 agonists remain largely unexplained. In present study, we examined effect exendin-4 on Ang II-induced migration...
CSRP3/MLP (cysteine-rich protein 3/muscle Lim protein), a member of the cysteine-rich family, is muscle-specific LIM-only factor specifically expressed in skeletal muscle. CSRP3 critical maintaining structure and function normal To investigate mechanism disease myopathy, we performed siRNA-mediated knockdown chicken primary myoblasts. silencing resulted down-regulation expression myogenic genes up-regulation atrophy-related gene expressions. We found that interacted with LC3 to promote...
Ferroptosis is a non‑apoptotic form of cell death that relies on iron and lipid peroxidation, which associated with multiple pathological processes in several diseases. Erastin small molecule capable initiating ferroptotic cancer cells, has shown great potential for therapy. However, the physiological role erastin‑induced ferroptosis healthy tissues not been well characterized. The present study intraperitoneally injected erastin into mice to detect metabolic changes mice. injection induced...
Although the prognosis of patients with occult hepatitis B virus (HBV) infection (OBI) is usually benign, a small portion may undergo cirrhosis and subsequently hepatocellular carcinoma (HCC). We studied mechanism life-long Integration DNA into OBI host's genome, which induce hepatocyte transformation. applied HBV capture sequencing on single cells from an patient who, developed multiple HCC tumors underwent liver resection in May 2013 at Tongji Hospital China. Despite undetectable serum, we...
Acute aortic dissection (AAD) and associated ruptures are the leading causes of death in cardiovascular diseases (CVDs). Hypertension is a prime risk factor for AAD. However, molecular mechanisms underlying AAD remain poorly understood. We previously reported that cyclic mechanical stretch (CMS) leads to rat smooth muscle cells (RASMCs). This review focuses on CMS-induced vascular cell (VSMC) death. Moreover, we have also discussed potential therapeutics preventing aneurysm ruptures.
Balanced translocations are common chromosomal structural abnormalities that usually do not involve a gain or loss of genetic material; and carriers display normal phenotypes intelligence. However, unbalanced rearranged gametes can be produced during the meiotic division reproductive cells, leading to infertility, miscarriage, stillbirth, birth newborns with malformations abnormalities. These adverse pregnancy outcomes create significant burdens for families societies affect quality life...
Multidrug resistance (MDR) confers agrochemical compatibility to fungal cells-based mycoinsecticdes but mechanisms involved in MDR remain poorly understood for entomopathogenic fungi, which have been widely applied as biocontrol agents against arthropod pests. Here we characterized the functions of five ATP-binding cassette (ABC) transporters, were classified subfamilies ABC-B (Mdr1), ABC-C (Mrp1) and ABC-G (Pdr1, Pdr2 Pdr5) selected from 54 full-size ABC proteins Beauveria bassiana based on...