A5100344597- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- COVID-19 and healthcare impacts
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Long-Term Effects of COVID-19
- Lung Cancer Research Studies
- Renal cell carcinoma treatment
- Gallbladder and Bile Duct Disorders
- SARS-CoV-2 and COVID-19 Research
- Neuroblastoma Research and Treatments
- Cancer Cells and Metastasis
- Functional Brain Connectivity Studies
- Gastric Cancer Management and Outcomes
- Atrial Fibrillation Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Alzheimer's disease research and treatments
- Cardiac Arrhythmias and Treatments
- Hepatitis B Virus Studies
- Adenosine and Purinergic Signaling
Jiangsu Cancer Hospital
2025
Nanjing Medical University
2025
The Ohio State University Wexner Medical Center
2016-2024
Zhejiang University
2019-2024
The First Affiliated Hospital, Sun Yat-sen University
2012-2024
Sun Yat-sen University
2012-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024
Shanghai University of Traditional Chinese Medicine
2024
Sir Run Run Shaw Hospital
2024
Fourth People's Hospital of Sichuan Province
2024
Abstract Objective To assess the efficacy and safety of hydroxychloroquine plus standard care compared with alone in adults coronavirus disease 2019 (covid-19). Design Multicentre, open label, randomised controlled trial. Setting 16 government designated covid-19 treatment centres China, 11 to 29 February 2020. Participants 150 patients admitted hospital laboratory confirmed were included intention treat analysis (75 assigned care, 75 alone). Interventions Hydroxychloroquine administrated at...
To evaluate the performance of a novel three-dimensional (3D) joint convolutional and recurrent neural network (CNN-RNN) for detection intracranial hemorrhage (ICH) its five subtypes (cerebral parenchymal, intraventricular, subdural, epidural, subarachnoid) in non-contrast head CT.A total 2836 subjects (ICH/normal, 1836/1000) from three institutions were included this ethically approved retrospective study, with 76,621 slices CT scans. ICH annotated by independent experienced radiologists,...
Abstract Objectives To assess the efficacy and safety of hydroxychloroquine (HCQ) plus standard–of–care (SOC) compared with SOC alone in adult patients COVID–19. Design Multicenter, open–label, randomized controlled trial. Setting 16 government–designated COVID–19 treatment centers China through 11 to 29 February 2020. Participants 150 hospitalized laboratory confirmed were included intention treat analysis. 75 assigned HCQ alone. Interventions was administrated a loading dose 1, 200 mg...
Compared to adults, there are relatively few studies on COVID-19 infection in children, and even less focusing the unique features of children terms laboratory findings, locations computerized tomography (CT) lesions, role CT evaluating clinical recovery. The objective this study is report results from patients at Wuhan Children's Hospital, located within initial center outbreak.Clinical, imaging, data 76 were collected retrospectively analyzed with Fisher exact test Cox regression...
We developed a computational model integrating clinical data and imaging features extracted from contrast-enhanced computed tomography (CECT) images, to predict lymph node (LN) metastasis in patients with pancreatic ductal adenocarcinoma (PDAC).This retrospective study included 159 PDAC (118 the primary cohort 41 validation cohort) who underwent preoperative examination between 2012 2015. All surgery status was determined. A total of 2041 radiomics were venous phase images cohort, optimal...
Background: Early detection of infected patients is one the most important steps to mitigate spreading 2019 novel coronavirus (2019-nCoV). Here, we report a set atypical 2019-nCoV pneumonia cases with gastrointestinal symptoms onset but without fever or other respiratory symptoms.Methods: We retrospectively reviewed data admitted only digestive and no on from January 17-24, in Renmin Hospital Wuhan University. The patients' history, clinical features, physical findings, complete blood count,...
Abstract Epithelial–mesenchymal transition (EMT) in cancer cells drives chemoresistance, yet the molecular events of EMT that underpin acquisition chemoresistance are poorly understood. Here, we demonstrate a loss gemcitabine chemosensitivity facilitated by human equilibrative nucleoside transporter 1 (ENT1) during pancreatic and identify cadherin switching from epithelial (E) to neuronal (N) type, hallmark EMT, contributes this loss. Our findings N-cadherin decreases ENT1 expression,...
Abstract We conducted an institutional study to compare the clinical and pathological efficacy between neoadjuvant therapy (NAT)‐modified FOLFIRINOX (mFOLF) vs nanoparticle albumin–bound paclitaxel plus gemcitabine (nab‐P/G) for borderline resectable pancreatic cancer (BRPC) locally advanced (LAPC) patients who completed resection. The retrospectively enrolled with pathologically confirmed BRPC or LAPC from 2010 2018 at our institution. survival rates were determined by Kaplan‐Meier method...
Pancreatoduodenectomy is a complex and challenging procedure that requires meticulous tissue dissection proficient suturing skills. Minimally invasive surgery with the utilization of robotic platforms has demonstrated advantages in perioperative patient outcomes retrospective studies. The development pancreatoduodenectomy (RPD) specific progressed significantly, since first reported 2003, high-volume centers pancreatic are reporting large series improved pain management reduced length stay....
Previous studies have compared the incidence of pertussis before and during COVID-19 pandemic, finding that public health measures related to contributed a temporary decline in reported cases pandemic. However, post-pandemic period has seen resurgence respiratory infections, influenced by relaxed decreased vigilance. This study investigates epidemiological dynamics among patients with acute tract infections (ARTI) Zhejiang Province, China, providing essential reference information for...
BackgroundThe utility of the proposed alternative fistula risk score (a-FRS) for predicting clinically relevant postoperative pancreatic (CR-POPF) after pancreaticoduodenectomy (PD) has not been validated widely.MethodsThis retrospective analysis included data patients undergoing open and laparoscopic PD during March 2012–May 2018 in our institution. The predictive abilities a-FRS original-FRS were compared. Risk factors CR-POPF also evaluated by multivariate regression analysis.ResultsOf...
FOLFIRINOX (FFX) or abraxane plus gemcitabine (AG)-based chemotherapy is used widely as firstline treatment for patients with pancreatic cancer. However, their use in the elderly discouraged because of adverse events. More clinical data about therapeutic response and tolerability to FFX AG patents (over 70 years old) are required.Patients advanced cancer (n = 203; 131 metastatic (MPC) 72 locally (LAPC)) were treated using modified-FFX (mFFX) mFFX sequentially. The grouped according age,...