A5100439340- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Renal cell carcinoma treatment
- Neural dynamics and brain function
- Autism Spectrum Disorder Research
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Heart Rate Variability and Autonomic Control
- Tactile and Sensory Interactions
- Anesthesia and Neurotoxicity Research
- Gaze Tracking and Assistive Technology
- Immune cells in cancer
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Ferroptosis and cancer prognosis
- Monoclonal and Polyclonal Antibodies Research
- EEG and Brain-Computer Interfaces
- Neurological Disease Mechanisms and Treatments
- Cancer Mechanisms and Therapy
- Gallbladder and Bile Duct Disorders
Zhejiang University
2013-2025
First Affiliated Hospital Zhejiang University
2019-2025
Zhejiang Cancer Hospital
2025
Third Affiliated Hospital of Zhengzhou University
2023-2025
The University of Texas MD Anderson Cancer Center
2024
New York University
2023
Bridge University
2023
Blood Center of Zhejiang Province
2020-2022
Guangzhou University of Chinese Medicine
2022
Shanghai Clinical Research Center
2020-2022
The progression and metastasis of pancreatic ductal adenocarcinoma (PDAC) is highly dependent on the tumour microenvironment. Most tumour-associated macrophages (TAMs) are M2 phenotype macrophages, which normally show anti-inflammatory functions in numerous disorders. Previously, we found that alternatively activated showed pro-inflammatory characteristics upon stimulation with hepatoma cell-derived debris; however, molecular mechanism was unclear.In vitro vivo experiments were employed to...
Abstract The amygdala, one of the most studied brain structures, integrates brain-wide heterogeneous inputs and governs multidimensional outputs to control diverse behaviors central survival, yet how amygdalar input-output neuronal circuits are organized remains unclear. Using a simplified cell-type- projection-specific retrograde transsynaptic tracing technique, we scrutinized afferent four major output groups in basolateral complex (BLA) that project bed nucleus stria terminals (BNST),...
Pancreatic ductal adenocarcinoma (PDAC) has little response to immune checkpoint inhibitors. An in-depth understanding of the microenvironment from a comprehensive and dynamic perspective is critical generate effective therapeutic strategies for PDAC.Using mass cytometry immunohistochemistry, we explored changes tumor-infiltrating cells during development PDAC in genetically engineered mouse model (KrasG12D/+; Trp53R172H/+; Pdx1-cre) human specimens. PD-L1-/- mice were crossed with...
Early life stress is thought to be a risk factor for emotional disorders, particularly depression and anxiety. Although the excitation/inhibition (E/I) imbalance has been implicated in neuropsychiatric whether early affects E/I balance medial prefrontal cortex at various developmental stages unclear. In this study, rats exposed maternal separation (MS) that exhibited well-established paradigm were used evaluate adolescence (postnatal day P43-60) adulthood (P82-100) by behavior tests,...
Recently, applying computational models developed in cognitive science to psychiatric disorders has been recognized as an essential approach for understanding mechanisms underlying symptoms. Autism spectrum disorder is a neurodevelopmental that hypothesized affect information processes the brain involving estimation of sensory precision (uncertainty), but mechanism by which observed symptoms are generated from such abnormalities not thoroughly investigated. Using humanoid robot controlled...
FOLFIRINOX (FFX) or abraxane plus gemcitabine (AG)-based chemotherapy is used widely as firstline treatment for patients with pancreatic cancer. However, their use in the elderly discouraged because of adverse events. More clinical data about therapeutic response and tolerability to FFX AG patents (over 70 years old) are required.Patients advanced cancer (n = 203; 131 metastatic (MPC) 72 locally (LAPC)) were treated using modified-FFX (mFFX) mFFX sequentially. The grouped according age,...
Nowadays, improving the traffic safety of visually impaired people is a topic widespread concern. To help avoid risks and hazards road in their daily life, we propose wearable device using object detection techniques novel tactile display made from shape-memory alloy (SMA) actuators. After detecting obstacles real-time, attached to user's hands presents different sensations show position obstacles. implement computation-consuming algorithm low-memory mobile device, introduced slimming...
ABSTRACT Introduction Standard treatments provide limited benefits for patients with intermediate‐ or advanced‐stage hepatocellular carcinoma (HCC). This retrospective observational study aimed to assess the potential improvements in outcomes associated systemic therapies receiving transarterial chemoembolization (TACE) initially unresectable HCC. Methods Between February 2019 and March 2023, we reviewed diagnosed intermediate‐to‐advanced HCC who were treated either TACE combined...
Context: Immune checkpoint blockades (ICBs) have been approved widely to treat various malignancies. Autoimmune diabetes mellitus, which can be caused by programmed cell death protein 1 (PD-1) inhibitors, is rare. Sintilimab, a monoclonal anti-PD-1 antibody, has in China for the treatment of Hodgkin's lymphoma and was used our clinical trial patients with unresectable hepatocellular carcinoma (HCC). Case Presentation: We present first case autoimmune during Sintilimab patient HCC,...
560 Background: FOLFIRINOX or modified (mFFX) is the standard of care for first line treatment metastatic pancreatic adenocarcinoma (PDAC). However, prognosis still remains poor, novel options are urgently need. Sintilimab, a human IgG4 monoclonal antibody that binds to programmed cell death receptor-1(PD-1), has shown remarkable efficacy in various cancers. We designed CISPD3-trial China, aimed determine and safety combination Sintilimab mFFX recurrent PDAC. Methods: In this single center,...
The pathogenesis of autism spectrum disorder (ASD) is not well understood, especially in terms immunity and inflammation, there are currently no early diagnostic or treatment methods. In this study, we obtained six existing Gene Expression Omnibus transcriptome datasets from the blood ASD patients. We performed functional enrichment analysis, PPI CIBERSORT algorithm, Spearman correlation with a focus on expression profiling hub genes immune cells. validated that monocytes nonclassical were...
Abstract Neurotoxic effects of general anesthetics, particularly sevoflurane, on pediatric neurodevelopment are a global concern. This study investigated the molecular and metabolic impacts repeated short exposures to sevoflurane in neonatal rats. Metabolomics analysis revealed significant changes fatty acid mitochondrial energy metabolism. Transcriptomic identified altered gene expression related function. Various analyses emphasized upregulation oxidative phosphorylation DNA repair...
Recently, the importance of application computational models utilized in cognitive neuroscience to psychiatric disorders has been recognized. This study utilizes a recurrent neural network model test aberrant sensory precision, normative theory autism spectrum disorder. We particularly focus on effects increased and decreased precision adaptive behavior based prediction error minimization mechanism. To distinguish dysfunction at behavioral levels, we employ humanoid robot driven by observe...
This study demonstrates that the prediction error minimization (PEM) mechanism can account for emergence of reciprocal interaction between two cognitive agents. During interactive processes, alternation forming and deforming interactions may be triggered by various internal external causes. We focus in particular on causes derived from a dynamic uncertain environment. Two small humanoid robots controlled an identical neural network model using PEM were trained to achieve set coherent...
The clinical factors associated with the recurrence of atrial fibrillation (Af) in patients undergoing catheter ablation (CA) are still ambiguous to date.1. To recognize preoperative serologic and features Af after first treatment. 2. Develop a Logical Regression Model for Predicting Likelihood Recurrence Within 1 Year After Initial Radio-Frequency Catheter Ablation (RFCA) Therapy.Atrial RFCA at our institution from January 2016 June 2021 were included analysis (n = 246). A combined dataset...
e14593 Background: IBI363 is a first-in-class PD-1/IL-2 α -bias bispecific antibody fusion protein which could block PD-1 checkpoint and rejuvenate exhausted tumor-specific T cells by cis-activating α-bias IL-2. It was well tolerated showed encouraging efficacy in patients (pts) with advanced melanoma, non-small cell lung cancer colorectal cancer. Herein, we report phase I study of other solid tumors. Methods: Eligible pts biliary tract (BTC), head neck squamous carcinoma (HNSCC), cervical...
3593 Background: The prognosis of advanced colorectal cancer (CRC) is poor with limited treatment options available. IBI363 a PD-1/IL-2 α-bias bispecific antibody that specifically activate PD-1(+)CD25(+) tumor specific T cells while sparing PD-1(-)CD25(-) bystander cells, and peripheral regulatory to protect the body from autoimmunity. Herein, we report safety efficacy in patients (pts) CRC phase I study. Methods: Eligible pts locally or metastatic who failed intolerant standard were...