A5091187256- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Advanced Chemical Sensor Technologies
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Tea Polyphenols and Effects
- Acute Myocardial Infarction Research
- Spectroscopy and Chemometric Analyses
- Heart Rate Variability and Autonomic Control
- Stroke Rehabilitation and Recovery
- Cardiovascular Health and Disease Prevention
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Antiplatelet Therapy and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Cardiac Arrhythmias and Treatments
- Folate and B Vitamins Research
- Neurological Disease Mechanisms and Treatments
- Child Nutrition and Water Access
- Cancer, Hypoxia, and Metabolism
- Coronary Interventions and Diagnostics
- Ferroptosis and cancer prognosis
- Diabetes Treatment and Management
Zhejiang University
2013-2025
Beijing Jishuitan Hospital
2024
Peking University
2024
Fujian Agriculture and Forestry University
2024
Soochow University
2022-2024
Tianjin Chest Hospital
2023
Tianjin University
2023
Tianjin Medical University
2023
Hangzhou Normal University
2023
University of Electronic Science and Technology of China
2022
Abstract Background This study investigates the relationship between triglyceride-glucose (TyG) index trajectories and results of ablation in patients with stage 3D atrial fibrillation (AF). Methods A retrospective cohort was carried out on who underwent AF Radiofrequency Catheter Ablation (RFCA) at Cardiology Department Fourth Affiliated Hospital Zhejiang University Taizhou Province from January 2016 to December 2022. The main clinical endpoint determined as occurrence arrhythmia for least...
Objective . To examine the gender, age, and region of residence in anthropometric nutritional profiles children adolescents aged 6–18 Henan Province, China’s third most populous province. Design This cross-sectional study China National Nutrition Health survey (2010–2013) used a multistage cluster sampling technique. The sample included Chinese schoolchildren 6 to 18 years (1,660 boys 1,561 girls). Multiple logistic regression models were estimate associations between sociodemographic...
Abstract Macrophages that acquire an immunosuppressive phenotype play a crucial role in establishing the pre-metastatic niche (PMN), which is essential for facilitating breast cancer metastasis to distant organs. Our study showed increased activity of aryl hydrocarbon receptor (AHR) lung macrophages plays PMN cancer. Specifically, AHR activation led high expression PD-L1 on by directly binding promoter Pdl1 . This upregulation promoted differentiation regulatory T cells (Tregs) within PMN,...
Background: Hyperhomocysteinemia was believed to be an independent risk factor for stroke and associate with small vessel disease (SVD) related large (LVD) differently.However it's still unclear which type of associated homocysteine (HCY) more strongly because the conclusions previous studies were contradictory.In this study we focused on subclinical angiopathies stroke, i.e., SVD LVD instead subtypes sought compare associations between HCY level different angiopathies.Methods: 324...
White matter lesion (WML) is popular in the patients aged over 65. Brain edema and blood-brain barrier (BBB) dysfunction due to cerebral chronic hypoperfusion (CCH) contributed WML. Preserving astrocyte polarity vital for BBB integrity. In our experiment, CCH model established by bilateral carotid arteries occlusion (2VO). Leukoaraiosis was verified fiber density stain, brain evaluated using water content measuring. The expressions of agrin aquaporin-4 (AQP4) were evaluated, as well...
Background Timely percutaneous coronary intervention (PCI) is crucial for restoring myocardial blood supply in ST-segment elevation infarction (STEMI) patients, with the first 72 h being a critical period early ventricular remodelling. The association between heart rate trajectories within this and after hospital discharge outcomes STEMI patients post-PCI remains unclear.
Structural remodeling of the left atrial appendage (LAA) is characteristic fibrillation (AF), and LAA morphology impacts radiofrequency catheter ablation (RFCA) outcomes. In this study, we aimed to develop validate a predictive model for AF outcomes using morphological features, deep learning (DL) radiomics, clinical variables. multicenter retrospective 480 consecutive patients who underwent RFCA at three tertiary hospitals between January 2016 December 2022 were analyzed, with follow-up...
Background: Late-onset depression (LOD) is a frequent mood disorder among elderly.Previous studies have proved that LOD associated with cerebral silent lesions especially white matter (WML) and yielded the "vascular depression" hypothesis to explain pathogenesis of LOD.However, there were relatively few about association between brain infarctions (SBIs), microbleeds (MBs) prevalence LOD.In this study we sought evaluate presence, accumulation locations SBIs MBs, explore possible them...
Background: Dietary tyrosine regulating melanoma progression has been well-recognized. However, whether tyrosine-based melanin anabolism contributes to pulmonary and cerebral organotropic colonization of remains elusive. Furthermore, approaches based on targeting tyrosinase activity inhibiting multi-organ metastasis cells need be designed validated. Methods: Patients derived mouse B16 with different pigmentation were employed in this investigation. Tyrosine content dynamics tumors multiple...
Background: Macrophages expressing CC chemokine receptor 2 (CCR2) possess characteristics and performance akin to M1 polarized macrophages, which promote inflammation. Advanced heart failure (HF) patients with higher abundance of CCR2+ macrophages are more likely experience adverse remodeling. The precise mechanism in how they affect the progression dilated cardiomyopathy remains unknown. Methods: Cardiac biopsy samples from (DCM) were used for immunohistochemistry immunofluorescence...
Late-life depression could be classified roughly as early-onset (EOD) and late-onset (LOD). LOD was proved to associated with cerebral lesions including white matter hyperintensities (WMH) silent brain infarctions (SBI), differently from EOD. However, it is unclear whether similar association present between microbleeds which are also lesions. In this study, 195 patients of late-life were evaluated divided into EOD, presenile-onset (POD), groups; 85 healthy elderly controls enrolled...
Background: Leukoaraiosis, microbleeds, and silent brain infarctions are phenotypes of small vessel disease.Leukoaraiosis is the most prevalent, advanced periventricular leukoaraiosis regarded as a strong predictor cognitive dysfunction.Microbleeds sometimes coexist with leukoaraiosis.This study aims to analyze effects microbleeds on function patients leukoaraiosis.Methods: 227 were divided into control, MB, SBI, MB&SBI groups.The presence locations evaluated.Mini-Mental State Examination,...
P38 mitogen-activated protein kinase (MAPK)12 (also known as γ) is critical in the development and progression of various types tumors. Despite extensive literature on subject, further studies are needed to elucidate its role cancer progression. Here, a comprehensive bioinformatics analysis generalized dataset was performed explore mechanism MAPK12 regulation tumorigenesis. Several tumor datasets online analytical tools, including HPA, SangerBox, UALCAN, GEPIA2, STRING, ImmuCellAI, MEXPRESS,...
OBJECTIVE: Silent brain infarctions are the silent cerebrovascular events that distinguished from symptomatic lacunar by their 'silence'; origin of these is still unclear.This study analyzed characteristics and sought to explore mechanism this 'silence'.METHODS: In total, 156 patients with only infarctions, 90 160 both 115 without any were recruited.Vascular risk factors, leukoaraiosis, vascular assessment results compared.The National Institutes Health Stroke Scale scores compared between...
<b><i>Background:</i></b> Isolated pontine infarctions are classified as paramedian infarction (PPI) and lacunar (LPI), usually attributed to basilar artery (BA) atherosclerosis small vessel disease (SVD), respectively. Recently, researchers found BA atherosclerotic plaques in LPI made the pathogenesis of confusing. <b><i>Methods:</i></b> We evaluated presence location with high-resolution MRI SVD burden hypertension, leukoaraiosis silent brain...
Objective Our study focused on acute lacunar infarct shapes to explore the risk factors and clinical significance of irregularly shaped infarctions. Methods Based shape their infarct, patients (n=204) were classified into “regular” group or “irregular” group. The characteristics infarction compared between regular irregular groups, with without neurological deterioration, different modified Rankin scale (mRS) scores. for infarctions, high mRS scores identified. Results Blood pressure...
The clinical factors associated with the recurrence of atrial fibrillation (Af) in patients undergoing catheter ablation (CA) are still ambiguous to date.1. To recognize preoperative serologic and features Af after first treatment. 2. Develop a Logical Regression Model for Predicting Likelihood Recurrence Within 1 Year After Initial Radio-Frequency Catheter Ablation (RFCA) Therapy.Atrial RFCA at our institution from January 2016 June 2021 were included analysis (n = 246). A combined dataset...
Background: The dilation of lymphatic vessels plays a critical role in maintaining heart function, while lack thereof could contribute to failure (HF), and subsequently an acute myocardial infarction (AMI). Macrophages participate the induction lymphangiogenesis by secreting vascular endothelial cell growth factor C (VEGF-C), although precise mechanism remains unclear. Methods: Intramyocardial injections adeno-associated viruses (AAV9) inhibit expression VEGFR3 (VEGFR3 shRNA) or promote ORF)...