A5044980104- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Bone fractures and treatments
- Shoulder and Clavicle Injuries
- Cerebrospinal fluid and hydrocephalus
- Hip and Femur Fractures
- Functional Brain Connectivity Studies
- Trauma Management and Diagnosis
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological diseases and metabolism
- Knee injuries and reconstruction techniques
- Pelvic and Acetabular Injuries
- Tendon Structure and Treatment
- Advanced MRI Techniques and Applications
- Orthopaedic implants and arthroplasty
- Spinal Dysraphism and Malformations
- Circular RNAs in diseases
- Cardiac and Coronary Surgery Techniques
- Stroke Rehabilitation and Recovery
- RNA regulation and disease
Beijing Anzhen Hospital
2010-2025
Capital Medical University
2010-2025
Xi'an Honghui Hospital
2014-2025
Xi'an Jiaotong University
2014-2025
Hospital for Special Surgery
2022-2025
Civil Aviation University of China
2024
Dalian Medical University
2024
Nanchong Central Hospital
2024
Yale University
2024
People’s University
2024
Alpha-synucleinopathy is postulated to be central both idiopathic rapid eye movement sleep behaviour disorder (iRBD) and Parkinson's disease (PD). Growing evidence suggests an association between the diminished clearance of α-synuclein glymphatic system dysfunction. However, accumulating primarily based on clinical data support dysfunction in patients with iRBD PD currently insufficient. This study aimed use diffusion tensor image analysis along perivascular space (DTI-ALPS) evaluate...
Ferroptosis, a novel form of regulated cell death, is caused by accumulation lipid peroxides and excessive iron deposition. This process has been linked to the death dopaminergic neurons in substantia nigra compacta (SNc) Parkinson's disease (PD) patients. Quercetin (QCT), natural flavonoid, multiple pharmacological activities. However, it not established whether QCT can protect against neuron inhibiting ferroptosis. In this study, we investigated potential antiferroptotic effects cellular...
The glymphatic system offers a perivascular pathway for the clearance of pathological proteins and metabolites to optimize neurological functions. Glymphatic dysfunction plays pathogenic role in Parkinson's disease (PD); however, molecular mechanism PD remains elusive. To explore whether matrix metalloproteinase-9 (MMP-9)-mediated β-dystroglycan (β-DG) cleavage is involved regulation aquaporin-4 (AQP4) polarity-mediated PD. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced A53T...
Aquaporin-4 (AQP4) facilitates a sleep-enhanced interstitial brain waste clearance system. This study was conducted to determine the clinical implication of AQP4 polymorphisms in Parkinson's disease (PD).Three-hundred and eighty-two patients with PD 180 healthy controls mean follow-up time 66.1 months from Progression Marker Initiative were analyzed. We examined whether SNPs associated an altered rate motor or cognitive decline using linear mixed model Cox regression. then investigated Aβ...
Abstract Major depressive disorder (MDD) is a serious mental that negatively affects the quality of life many individuals, and heavy economic burden to society. In recent years it was thought depression ‘disconnection syndrome’. Disorganized brain activity un-modulated emotion responses were considered key neuropathologies underlying depression. present study, we investigated alteration whole network connectivity in 28 first-episode, drug-naive patients, using resting-state functional...
Dysfunction of the glymphatic system, an intracranial clearance pathway that drains misfolded proteins, has been implicated in onset Parkinson’s disease (PD). Recently, coupling strength global blood-oxygen-level-dependent (gBOLD) signals and cerebrospinal fluid (CSF) inflow dynamics have suggested to be indicator function. Using resting-state functional magnetic resonance imaging (MRI), we quantified gBOLD–CSF as cross-correlation between baseline gBOLD CSF evaluate function its association...
Abstract Background We previously identified a significant association between Aquaporin‐4 ( AQP4 ) and Parkinson's disease (PD). Objectives To identify whether single‐nucleotide polymorphism (SNP) rs162009 affects regional brain activity clinical phenotypes of PD. Methods Low‐frequency fluctuation amplitude (ALFF) was used to evaluate spontaneous activity, homogeneity (ReHo) the pace adjacent voxel regions, degree centrality (DC) describe functional connection strength whole brain. Disease...
Background: Excessive aggregation of α-synuclein is the key pathophysiological feature Parkinson's disease (PD). Rapid eye movement sleep behavior disorder (RBD) also associated with synucleinopathies and considered as a powerful predictor PD. Growing evidence suggests diminished clearance may be partly attributable to poor interstitial fluid drainage, which can reflected by magnetic resonance imaging (MRI)-visible enlarged perivascular space (EPVS). However, effect MRI-visible EPVS on iRBD...
ABSTRACT Background Emerging evidence indicates that the apolipoprotein E ( APOE ) ε4 exacerbates α‐synuclein pathology. Objective To determine whether contributes to motor progression in early Parkinson's disease (PD). Methods Longitudinal data were obtained from 384 patients with PD divided into carriers n = 85) and noncarriers 299) Progression Marker Initiative. Participants underwent yearly assessments over a mean follow‐up period of 78.9 months. Repeated measures linear mixed models...
Abstract Background Dysfunction of iron metabolism, especially in substantia nigra (SN), is widely acknowledged Parkinson's disease (PD), but the genetic influence on deposition remains largely unknown. Thus, this study, we aimed to investigate potential impacts PD. Methods Seventy‐four subjects, including 38 patients with PD and 36 age‐matched normal controls, participated study. Imaging association analysis was used identify specific single nucleotide polymorphism (SNP) iron‐related...
ABSTRACT The tendon graft is known to undergo a remodeling process after anterior cruciate ligament (ACL) reconstruction. However, little about the transcriptional profile of this process. aim present study identify differentially expressed genes inside ACL in early phase reconstruction our murine model using RNA sequencing (RNAseq). Fifty four male C57BL/6 mice were used study. euthanized at 1, 2, and 4 weeks surgery for histological evaluations RNAseq graft. Histologically, there was...
This retrospective study aimed to investigate the effect of mild-to-moderate COVID-19 on risk deep vein thrombosis (DVT) in patients with hip fractures. Hip fractures are common elderly, and previous research has shown that they accounted for 58.3% traumatic older inpatients during pandemic China. Meanwhile, relationship between DVT is complex. Some studies have reported incidence critically ill can be as high 46%, 20% those moderate-to-severe cases. However, impact fracture remains unclear....
This study aimed to evaluate the safety and feasibility of carotid artery stenting (CAS) using a 6 F guiding catheter via right distal radial access. The clinical data 32 patients who underwent internal C1 transradial access (rdTRA) at Department Cerebrovascular Diseases, Beijing Anzhen Hospital, between January 2022 December 2023, were retrospectively analyzed. Parameters including puncture time, X-ray irradiation exposure dose, surgical success rate, surgery-related cardiovascular...
This study aimed to assess the effects of distal transradial access (dTRA) compared conventional (cTRA) on procedure duration and radiation exposure among patients undergoing carotid artery stenting. The included 131 who underwent cerebrovascular interventional diagnosis treatment in Department Cerebrovascular Diseases at Beijing Anzhen Hospital, Capital Medical University, from January 2022 April 2024. Patients were categorized into dTRA cTRA groups based puncture site. Clinical laboratory...
Perivascular spaces in the brain have been known to communicate with cerebrospinal fluid and contribute waste clearance animal models. In this study, we sought determine association between MRI-visible enlarged perivascular (EPVS) disease markers Parkinson's (PD). We obtained longitudinal data from 245 patients PD 98 healthy controls Progression Marker Initiative. Two trained neurologists performed visual ratings on T2-weighted images characterize EPVS centrum semiovale (CSO), basal ganglia...