A5036667054- Tendon Structure and Treatment
- Sports injuries and prevention
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Hydrogels: synthesis, properties, applications
- Osteoarthritis Treatment and Mechanisms
- Exercise and Physiological Responses
- Total Knee Arthroplasty Outcomes
- Orthopedic Surgery and Rehabilitation
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Bone Tissue Engineering Materials
- Coronary Interventions and Diagnostics
- Acoustic Wave Resonator Technologies
- Cardiovascular and exercise physiology
- Silicon Nanostructures and Photoluminescence
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Advanced Fiber Optic Sensors
- Ferroelectric and Piezoelectric Materials
- Advanced ceramic materials synthesis
- Xenotransplantation and immune response
- Solar and Space Plasma Dynamics
- Shoulder and Clavicle Injuries
- Near-Field Optical Microscopy
Hospital for Special Surgery
2017-2025
St. Luke's International Hospital
2025
John Wiley & Sons (United States)
2021
Doshisha University
2019
Hokkaido University
2002-2018
Japan Aerospace Exploration Agency
2015
University of Electro-Communications
2008
Tokyo Institute of Technology
2002-2006
Tohoku University
2005-2006
Hiroshima University
1995-1998
On implanting hydroxyapatite-mineralized tough hydrogel into osteochondral defects of rabbits, osteogenesis spontaneously penetrates the gel matrix owing to semi-permeablility hydrogel. The gradient layer (around 40 μm thick) contributes quite strong bonding bone. This is first success in realizing robust osteointegration hydrogels, and method simple feasible for practical use. Recent progress developing hydrogels has made these highly water-containing materials promising substitutes soft...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 296:251-262 (2005) - doi:10.3354/meps296251 Effects of male mating frequency and size on ejaculate reproductive success female spiny king crab Paralithodes brevipes Taku Sato1,*, Masakazu Ashidate2,3, Satoshi Wada1,4, Seiji Goshima1 1Laboratory Biodiversity, Graduate School Fisheries Sciences, Hokkaido...
Background: Artificial meniscal scaffolds are being developed to prevent development of osteoarthritis after meniscectomy. Previously, it was reported that 3-dimensional (3D) anatomic loaded with connective tissue growth factor (CTGF) and transforming β3 (TGF-β3) achieved regeneration in an ovine model. This a relatively short-term study (3 months postoperative), outcome analyses did not include magnetic resonance imaging (MRI). Purpose: To evaluate long-term replacement factor–laden...
Tendon injuries are a common clinical condition with limited treatment options. The cellular components of the innate immune system, such as neutrophils and macrophages, have been studied in tendon injuries. However, adaptive comprising specialized lymphocytes, plays an important role orchestrating healing numerous tissues, but less is known about these cells healing. To gain greater understanding biological processes that regulate healing, we determined how system respond to injury using...
Macrophages are important for repair of injured tissues, but their role in healing after surgical musculoskeletal tissues is not well understood. We used single-cell RNA sequencing (RNA-seq), flow cytometry, and transcriptomics to characterize functional phenotypes macrophages a mouse anterior cruciate ligament reconstruction (ACLR) model that involves bone injury followed by phase fibrovascular interface tissue formation results bone-to-tendon attachment. identified novel "surgery-induced"...
ABSTRACT Subacromial impingement of the rotator cuff is understood as a contributing factor in development tendinopathy. However, changes that occur impinged tendon are poorly and warrant further study. To enable study tendinopathy, we performed controlled laboratory to determine feasibility baseline characteristics new murine model for subacromial impingement. This involves surgically inserting microvascular clip into space adult C57Bl/6 mice. Along with sham surgery arm, 90 animals were...
Mechanical stress has an important effect on tendon-to-bone healing. The purpose of the present study was to compare healing in animals exposed either tendon unloading (botulinum toxin injection) or excessive loading (treadmill running) a murine rotator cuff repair model. Forty-eight C57BL/6 mice underwent unilateral supraspinatus detachment and repair. Mice unloaded group were injected with botulinum muscle. contralateral shoulder used as control. euthanized at 1, 2, 4 weeks after surgery...
Background: The purpose of this study was to assess mitochondrial dysfunction in a murine model supraspinatus tendinopathy. Methods: Eighty-four mice (168 limbs) were included the study. Supraspinatus tendinopathy induced by inserting microsurgical clip subacromial space 63 bilaterally (126 limbs). Forty-two these limbs harvested at 4 weeks postoperatively, 42 underwent removal after initial procedure and 2 weeks, weeks. remaining 21 did not undergo surgical intervention utilized as control...
Tendon is a hypocellular, matrix-rich tissue that has been excluded from comparative transcriptional atlases. These atlases have provided important knowledge about biological heterogeneity between tissues, and our study addresses this gap. We performed measures on four of the most studied tendons, Achilles, forepaw flexor, patellar supraspinatus tendons both mice rats. are functionally distinct also among commonly injured, therefore translational interest. Approximately one-third filtered...
ABSTRACT The tendon graft is known to undergo a remodeling process after anterior cruciate ligament (ACL) reconstruction. However, little about the transcriptional profile of this process. aim present study identify differentially expressed genes inside ACL in early phase reconstruction our murine model using RNA sequencing (RNAseq). Fifty four male C57BL/6 mice were used study. euthanized at 1, 2, and 4 weeks surgery for histological evaluations RNAseq graft. Histologically, there was...
Lubricin, a mucinous glycoprotein, plays chondroprotective role as constituent of synovial fluid. Structural analogs have been synthesized to mimic the structure and function native lubricin in an effort recapitulate this effect with goal delaying progression osteoarthritis (OA).To investigate efficacy intra-articular injections mimetics slowing or preventing posttraumatic OA by using rat anterior cruciate ligament transection model.Controlled laboratory design.Four were investigated,...
Subacromial impingement is associated with a spectrum of disorders-including rotator cuff disease-but their relationship complex. We have established novel murine model subacromial to study supraspinatus tendinopathy. The purpose this was evaluate changes in gene expression shoulder further elucidate the mechanisms underlying development Twenty-eight C57BL/6 mice were used study. All underwent bilateral surgery insertion small metal clip space or sham procedure. tendons histological...
Abstract The aim of this study was to investigate the presence alarmins in a novel murine rotator cuff tendinopathy model. Alarmins have been described as essential early activators an immune response tissue damage. Subacromial impingement induced both shoulders 37 male C57Bl/6 mice by placement small metal clip subacromial space. Animals were allocated different time points up 6 weeks. morphology and cellularity supraspinatus tendon evaluated hematoxylin‐eosin staining, alcian blue,...
Background: Remnant tissue preservation may be important in improving graft healing after anterior cruciate ligament (ACL) reconstruction, but it has yet to established whether remnant improves the control of pivot-shift laxity. Hypothesis: The amount ACL coverage with preserved laxity, as qualitatively determined an electromagnetic device. Study Design: Cohort study; Level evidence, 3. Methods: 3-dimensional kinematics were evaluated intraoperatively using sensor system 38 patients at time...
ABSTRACT Excessive MMP activity may impair tendon‐to‐bone healing. However, little is known about the effect of joint motion on after ACL reconstruction. The aim this study was to determine different durations knee immobilization in a mouse reconstruction model using fluorescent probe which detects 2, 3, 9, and 13 near‐infra red vivo imaging. Sixty C57BL male mice underwent Post‐operatively, animals were treated with free cage (Group 1), or use an external fixator restrict weight bearing for...
Emerging data suggest that human cells derived from extraembryonic tissues may have favorable musculoskeletal repair properties. The purpose of this study was to determine whether the injection placenta-derived mesenchymal-like stromal cells, termed placental expanded (PLX-PAD), would improve tendon healing in a preclinical model tendinopathy.Sixty male Sprague-Dawley rats underwent bilateral patellar with either saline solution (control) or PLX-PAD (2 × 10 cells/100 µL) 6 days after...
We analyzed an acceleration pattern during natural walking and hampered by wearing weights to predict falls. These two types of could be distinguished with a peak at the half principal frequency gait in anterior movement. measured while each individual hampering weight then analyzed. The was bigger when subject wore that restrictive made body unbalanced. As leg accidents are considered occur change balance, our system may used detect accident checking movement