A5007462816- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Ion channel regulation and function
- Cerebrospinal fluid and hydrocephalus
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Ion Channels and Receptors
- Neural dynamics and brain function
- Tea Polyphenols and Effects
- Spinal Dysraphism and Malformations
- Phytoestrogen effects and research
- Health, Environment, Cognitive Aging
- Muscle Physiology and Disorders
- Biochemical Analysis and Sensing Techniques
- Calcium signaling and nucleotide metabolism
- Gut microbiota and health
- Sirtuins and Resveratrol in Medicine
- Cerebral Palsy and Movement Disorders
Second Affiliated Hospital of Zhejiang University
2020-2025
South China Normal University
2024
Zhejiang University
2021-2024
Kunming University
2023
South China University of Technology
2015-2021
University of Wisconsin–Madison
2020-2021
Soochow University
2019
South Central Minzu University
2015-2018
Alpha-synucleinopathy is postulated to be central both idiopathic rapid eye movement sleep behaviour disorder (iRBD) and Parkinson's disease (PD). Growing evidence suggests an association between the diminished clearance of α-synuclein glymphatic system dysfunction. However, accumulating primarily based on clinical data support dysfunction in patients with iRBD PD currently insufficient. This study aimed use diffusion tensor image analysis along perivascular space (DTI-ALPS) evaluate...
Angiotensin-converting enzyme 2 (ACE2) is a host receptor for severe acute respiratory syndrome coronavirus (SARS-CoV-2). Inhibiting the interaction between envelope spike glycoproteins (S-proteins) of SARS-CoV-2 and ACE2 potential antiviral therapeutic approach, but little known about how dietary compounds interact with ACE2. The objective this study was to determine if flavonoids other polyphenols B-ring 3',4'-hydroxylation inhibit recombinant human (rh)ACE2 activity. rhACE2 activity...
Abstract Increasing evidence suggests that Parkinson’s disease (PD) exhibits disparate spatial and temporal patterns of progression. Here we used a machine-learning technique—Subtype Stage Inference (SuStaIn) — to uncover PD subtypes with distinct trajectories clinical neurodegeneration events. We enrolled 228 patients 119 healthy controls comprehensive assessments olfactory, autonomic, cognitive, sleep, emotional function. The integrity substantia nigra (SN), locus coeruleus (LC), amygdala,...
Glymphatic dysfunction may contribute to the accumulation of Alzheimer's disease (AD) pathologies. Conversely, AD pathologic change might also cause neuroinflammation and aggravate glymphatic dysfunction, forming a loop that accelerates progression. In vivo validations are needed confirm their relationships.In this study, we included 144 cognitively normal participants with pathological biomarker data (baseline CSF Aβ1-42, T-Tau, P-Tau181; plasma P-Tau181 at baseline least one follow-up)...
Abstract Cerebral small vessel disease (SVD) can disrupt the global brain network and lead to cognitive impairment. Conversely, reserve (CR) improve one's ability handle damaging effects like SVD, partly by optimizing network's organization. Understanding how SVD CR collectively influence networks could be instrumental in preventing Recently, redundancy has emerged as a critical protective metric, providing nuanced perspective of changes However, it remains unclear affect subsequently...
Background: Predicting the prognosis of mild cognitive impairment (MCI) has outstanding clinical value, and hippocampal volume is a reliable imaging biomarker AD diagnosis. Objective: We aimed to longitudinally assess sub-regional difference (volume asymmetry) among progressive MCI (pMCI), stable (sMCI) patients, normal elderly. Methods: identified 29 pMCI, 52 sMCI, 102 controls (NC) from ADNI database. All participants underwent neuropsychological assessment 3T MRI scans three times. The...
The objective of this study was to determine the extent that aronia berry matrix affects gut microbiota composition, fecal short chain fatty acids (SCFAs), and colonic anthocyanins in healthy mice. C57BL/6J mice were fed AIN-93 M control diet (C) or C with whole (AB), extract (AE), polyphenol-depleted AB (D) at expense cornstarch. After one week feeding, D increased more than AE. Diets differentially affected SCFA microbiota. associated metabolism succinate pyruvate butyrate. acetic acid...
Rapid eye movement (REM) sleep behavior disorder (RBD) could develop preceding or come after motor symptoms during Parkinson's disease (PD). It remains unknown that whether PD with different timing of RBD onset relative to suggests spatiotemporal sequence neurodegeneration. This study aimed explore the progression in crucially involved brain regions onset. We recruited 157 PD, 16 isolated (iRBD), and 78 healthy controls. patients were identified as (1) (PD-preRBD, n = 50), (2) posterior...
Abstract Aims To detect functional connectomes of akinetic‐rigid (AR) and tremor compare their connection pattern. Methods Resting‐state MRI data 78 drug‐naïve PD patients were enrolled to construct AR via connectome‐based predictive modeling (CPM). The further validated with 17 verify replication. Results related identified CPM method successfully in the independent set. Additional regional‐based demonstrated neither nor could be simplified changes within a single brain region....
Abstract Background Dysfunction of iron metabolism, especially in substantia nigra (SN), is widely acknowledged Parkinson's disease (PD), but the genetic influence on deposition remains largely unknown. Thus, this study, we aimed to investigate potential impacts PD. Methods Seventy‐four subjects, including 38 patients with PD and 36 age‐matched normal controls, participated study. Imaging association analysis was used identify specific single nucleotide polymorphism (SNP) iron‐related...
Neuropsychiatric symptoms (NPS) are prevalent in cognitively impaired individuals including Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI). Whereas several studies have reported the associations between NPS with AD pathologic biomarkers cerebral small vessel (SVD), but it remains unknown whether pathology SVD contribute to different sub-syndromes independently or aggravate same synergistically. We included 445 (including 316 MCI 129 AD) neuropsychiatric, cerebrospinal...
ABSTRACT We investigated whether aquaporin‐4 (AQP4) single‐nucleotide polymorphisms (SNPs) influence Alzheimer's disease (AD) progression through changes in the glymphatic system. included 242 non‐dementia participants and chose six SNPs previously shown to be related AD. analyzed associations between AQP4 markers, including enlarged perivascular spaces (PVS), white matter free water (FW), diffusion tensor image analysis along space (DTI‐ALPS), both cross‐sectional longitudinal data....
Degeneration of the locus coeruleus (LC) is recognized as a critical hallmark Parkinson's disease (PD). Recent studies have reported that noradrenaline produced from LC has effects on brain functional organization. However, it unknown if degeneration in PD contributes to cognitive/motor manifestations through modulating This study enrolled 94 patients and 68 healthy controls, integrity was measured using contrast-to-noise ratio (CNRLC) calculated T1-weighted magnetic resonance imaging. We...
Abstract Dopamine replacement therapy (DRT) represents the standard treatment for Parkinson's disease (PD), however, instant and long‐term medication influence on patients' brain function have not been delineated. Here, a total of 97 drug‐naïve patients, 43 patients under DRT, 94 normal control (NC) were, retrospectively, enrolled. Resting‐state functional magnetic resonance imaging data motor symptom assessments were conducted before after levodopa challenge test. Whole‐brain connectivity...
The participation of large-conductance Ca2+ activated K+ channels (BKs) in chloroquine (chloro)-induced relaxation precontracted airway smooth muscle (ASM) is currently undefined. In this study we found that iberiotoxin (IbTx, a selective inhibitor BKs) and chloro both completely blocked spontaneous transient outward currents (STOCs) single mouse tracheal cells, which suggests might block BKs. We further inhibited sparks caffeine-induced global increases. Moreover, can directly BK from the...
Abstract Concomitant neuropsychiatric symptoms (NPS) are associated with accelerated Alzheimer's disease (AD) progression. Identifying multimodal brain imaging patterns NPS may help understand pathophysiology correlates AD. Based on the AD continuum, a supervised learning strategy was used to guide four‐way neuroimaging fusion (Amyloid, Tau, gray matter volume, function) by using total score as reference. Loadings of identified were compared across continuum. Then, regression analyses...
Abstract Objective This study investigated cerebral small vessel disease (CSVD) damage patterns in early‐onset and late‐onset Alzheimer's (EOAD LOAD) their effects on cognitive function. Methods included 93 participants, 45 AD patients (14 EOAD 31 LOAD), 48 normal controls (13 YNC 35 ONC) from the ADNI database. All participants had diffusion tensor imaging data; some amyloid PET plasma p‐tau 181 data. The used peak width of skeletonized mean diffusivity (PSMD) to measure CSVD severity...
Abstract Background and purpose The specific pathophysiological mechanisms underlying postural instability/gait difficulty (PIGD) cognitive function in Parkinson's disease (PD) remain unclear. Both gait control, as well function, are associated with the cholinergic basal forebrain (cBF) system. Methods A total of 84 PD patients 82 normal controls were enrolled. Each participant underwent motor assessments. Diffusion tensor imaging was used to detect structural abnormalities cBF segmented...