A5090313289- Acupuncture Treatment Research Studies
- Pain Mechanisms and Treatments
- Pain Management and Placebo Effect
- Healthcare and Venom Research
- Pharmacological Effects of Natural Compounds
- Myofascial pain diagnosis and treatment
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Infrared Thermography in Medicine
- Neuropeptides and Animal Physiology
- Cerebrovascular and Carotid Artery Diseases
- Thermoregulation and physiological responses
- Adenosine and Purinergic Signaling
- Stress Responses and Cortisol
- Musculoskeletal pain and rehabilitation
- Neuroscience and Neuropharmacology Research
- Heart Rate Variability and Autonomic Control
- Thermal Regulation in Medicine
- Vascular Procedures and Complications
- Wound Healing and Treatments
- Traditional Chinese Medicine Studies
- Complementary and Alternative Medicine Studies
- Vagus Nerve Stimulation Research
- Memory and Neural Mechanisms
- Pain Management and Treatment
Capital Medical University
2010-2025
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2017-2025
Beijing Anzhen Hospital
2010-2025
Zhejiang Chinese Medical University
2013-2024
Beijing Chao-Yang Hospital
2024
Guizhou University
2023
Patients First
2020
Weatherford College
2020
National University of Defense Technology
2018
Riverside Hospital of Guangxi Zhuang Autonomous Region
2016
Abstract Background Paclitaxel is a widely prescribed chemotherapy drug for treating solid tumors. However, paclitaxel-induced peripheral neuropathy (PIPN) common adverse effect during paclitaxel treatment, which results in sensory abnormalities and neuropathic pain among patients. Unfortunately, the mechanisms underlying PIPN still remain poorly understood. Long noncoding RNAs (lncRNAs) are novel promising targets chronic but their involvement remains unexplored. Methods We established rat...
Chronic pain, such as neuropathic causes anxiety and other negative emotions, which aggravates the pain sensation increases risk of chronic over time. Dopamine receptor D1 (DRD1) dopamine D2 (DRD2) in basolateral amygdala (BLA) have been implicated mediating anxiety-related behaviors, but their potential roles BLA pain-induced not examined. Electroacupuncture (EA) is commonly used to treat emotional disorders, it still unclear whether EA plays a role analgesia relief through DRD1 DRD2 BLA....
Abstract Aims Epidemiological studies in patients with neuropathic pain have demonstrated a strong association between and psychiatric conditions such as anxiety. Preclinical clinical work has that electroacupuncture (EA) effectively alleviates anxiety‐like behaviors induced by chronic pain. In this study, potential neural circuitry underlying the therapeutic action of EA was investigated. Methods The effects stimulation on mechanical allodynia animal models spared nerve injury (SNI) were...
Abstract Aims Negative emotions induced by chronic pain are a serious clinical problem. Electroacupuncture (EA) is clinically proven safe and effective method to manage pain‐related negative emotions. However, the circuit mechanisms underlying effect of EA treatment on remain unclear. Methods Plantar injection complete Freund's adjuvant (CFA) was performed establish rat model inflammatory pain‐induced anxiety‐like behaviors. Adeno‐associated virus (AAV) tracing used identify excitatory...
Recent studies have confirmed that pain memory is often accompanied by negative emotions. Electroacupuncture (EA) can block the retrieval of painful memories, thereby alleviating associated behaviors. However, underlying mechanism poorly understood. This study revealed effect EA on memory-induced behaviors related to mediation GABAergic neuron activity and GABA receptor expression in rostral anterior cingulate cortex (rACC). Previous shown rACC a crucial area for regulating nociceptive...
Painful diabetic neuropathy (PDN) is a common and troublesome diabetes complication. Protein kinase C (PKC)-mediated dorsal root ganglia (DRG) P2X3 receptor upregulation one important mechanism underlying PDN. Accumulating evidence demonstrated that electroacupuncture (EA) at low frequency could effectively attenuate neuropathic pain. Our previous study showed 2-Hz EA relieve pain well in The aimed to investigate whether relieves PDN through suppressing PKC-mediated DRG upregulation. A...
Anxiety is a common comorbidity associated with chronic pain, which results in pain complexification and difficulty treatment. Electroacupuncture (EA) commonly used to treat anxiety. However, the underlying mechanisms of EA effect are largely unknown. Here, we showed that circuitry induces anxiety disorders, can them by regulating such circuitry. Using chemogenetic methods, found activation rostral anterior cingulate cortex (rACC) glutamatergic output thalamus induced disorders control rats....
Lipid metabolism plays an important role in the repair of skin wounds. Studies have shown that acupuncture is very effective wound repair. However, there little knowledge about mechanism electroacupuncture. Thirty-six SD rats were divided into three groups: sham-operated group, model group and electroacupuncture with 12 each group. After intervention, local tissues collected for lipid metabolomics analysis, perfusion ferroptosis-related indexes detected finally effect on was comprehensively...
Abstract Background Gout results from disturbed uric acid metabolism, which causes urate crystal deposition in joints and surrounding tissues. pain management is largely limited to colchicine nonsteroidal anti-inflammatory drugs. Constant usage of these medications leads severe side effects. We previously showed electroacupuncture (EA) effective for relieving animal model gout arthritis. Here we continued study the mechanisms underlying how EA alleviates pain. Methods Monosodium was injected...
Chronic inflammatory pain is a common clinical disease that tends to be associated with negative emotions such as anxiety and depression. The anterior cingulate cortex (ACC) involved in pain-related anxiety, γ-aminobutyric acid (GABA)-ergic interneurons play an important role chronic anxiety. Electroacupuncture (EA) has good analgesic antianxiety effect, but the underlying mechanisms have not yet been fully elucidated. In this study, we established model observed induced anxiety-like...
Neuropathic pain is a common cause of chronic and often accompanied by negative emotions, making it complex difficult to treat. However, the neural circuit mechanisms underlying these symptoms remain unclear. Herein, we present novel pathway associated with comorbid anxiety. Using chemogenetic methods, found that activation glutamatergic projections from rostral anterior cingulate cortex (rACC Glu ) ventrolateral periaqueductal gray (vlPAG) induced both hyperalgesia anxiety-like behaviors in...
Pain memory is commonly considered an underlying cause of chronic pain and also responsible for a range anxiety. Electroacupuncture (EA) has been shown to ameliorate memories exert anti-anxiety effects. Previous research indicated that GABAergic neurons and/or GABA receptors (GABARs) in the midcingulate cortex (MCC) have potential associations with However, there no known empirical specifically studied effects EA on system MCC. Here, we used cross-injection carrageenan establish rats model....
The pain-depression dyad is becoming widespread in the clinic and attracting increasing attention. A previous study by our group found that 100‑Hz electro‑acupuncture (EA), but not 2‑, 50‑ 2/100‑Hz EA, was effective against reserpine‑induced pain‑depression dyad. This finding contrast to fact low‑frequency EA commonly used treat supraspinal‑originating diseases. present aimed investigate mechanism underlying effects of on Repeated reserpine injection induce allodynia depressive behaviors...
Background: Clinical patients suffering from pain usually exhibit aversion to pain-associated environments (pain aversion). Electro-acupuncture (EA) has been proven be effective for the treatment of in our previous studies. The amygdala could have substantial consequences on emotion and consolidation as well general behavior, however, underlying mechanism remains unclear. Purpose: current study was performed investigate Isobaric tags relative absolute quantitation (iTRAQ) based quantitative...
Abstract Diabetic neuropathic pain (DNP) is a troublesome diabetes complication all over the world. P2X3 receptor (P2X3R), purinergic from dorsal root ganglion (DRG), has important roles in pathology and nociceptive sensations. Here, we investigated involvement of DRG P2X3R effect 2 Hz electroacupuncture (EA) on DNP. We monitored rats’ body weight, fasting blood glucose level, paw withdrawal thresholds, latency, evaluated expression DRG. found that upregulated DNP, while EA analgesic against...
Diabetic neuropathic pain (DNP) is a frequent complication of diabetes. Calcium/calmodulin-dependent protein kinase II α (CaMKIIα), multi-functional serine/threonine subunit, mainly located in the surface layer spinal cord dorsal horn (SCDH) and primary sensory neurons root ganglion (DRG). Numerous studies have indicated electroacupuncture (EA) takes effect various kinds pain. In this research, we explored whether CaMKIIα on rats’ SCDH DRG participated DNP further mechanisms underlying...
Comorbid chronic neuropathic pain and anxiety is a common disease that represents major clinical challenge. The underlying mechanisms of are not entirely understood, which limits the exploration effective treatment methods. Glutamatergic neurons in ventrolateral periaqueductal gray (vlPAG) have been implicated regulating pain, but potential roles vlPAG pain-induced investigated. Herein, whole-cell recording immunofluorescence showed excitability CamkIIα (vlPAG CamkIIα+ neurons) was decreased...
This study aimed to evaluate the safety and feasibility of carotid artery stenting (CAS) using a 6 F guiding catheter via right distal radial access. The clinical data 32 patients who underwent internal C1 transradial access (rdTRA) at Department Cerebrovascular Diseases, Beijing Anzhen Hospital, between January 2022 December 2023, were retrospectively analyzed. Parameters including puncture time, X-ray irradiation exposure dose, surgical success rate, surgery-related cardiovascular...
This study aimed to assess the effects of distal transradial access (dTRA) compared conventional (cTRA) on procedure duration and radiation exposure among patients undergoing carotid artery stenting. The included 131 who underwent cerebrovascular interventional diagnosis treatment in Department Cerebrovascular Diseases at Beijing Anzhen Hospital, Capital Medical University, from January 2022 April 2024. Patients were categorized into dTRA cTRA groups based puncture site. Clinical laboratory...
Pain memory, which includes sensory and emotional is one of the main causes pain complications prolongation. Recent research has identified insular cortex (IC) as a critical brain region involved in integration information pertaining to pain, emotion, reward, cognition memory. GABAergic neuronal activity IC been demonstrated be strongly correlated with manifestation pain-related aversive behavior. Electroacupuncture (EA) relieves memory by activating μ opioid receptors (MORs) IC. The results...