A5047274477- Pain Mechanisms and Treatments
- Acupuncture Treatment Research Studies
- Pain Management and Placebo Effect
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Healthcare and Venom Research
- Atherosclerosis and Cardiovascular Diseases
- Air Quality Monitoring and Forecasting
- Circadian rhythm and melatonin
- Thermoregulation and physiological responses
- Endoplasmic Reticulum Stress and Disease
- Pharmacology and Obesity Treatment
- Berberine and alkaloids research
- Traditional Chinese Medicine Analysis
- Neurological disorders and treatments
- Cancer, Lipids, and Metabolism
- Ion Channels and Receptors
- Atmospheric chemistry and aerosols
- Ginseng Biological Effects and Applications
- Heart Rate Variability and Autonomic Control
- Pharmacological Effects of Natural Compounds
- Myofascial pain diagnosis and treatment
- RNA regulation and disease
- Nitric Oxide and Endothelin Effects
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2019-2024
Zhejiang University
2023-2024
Zhejiang Chinese Medical University
2016-2023
Zhejiang Lab
2023
Chronic inflammatory pain is one of the most common complaints that seriously affects patients’ quality life. Previous studies have demonstrated analgesic effect electroacupuncture (EA) stimulation on related to its frequency. In this study, we focused whether effects EA are period stimulation. Purinergic receptor P2X3 (P2X3) involved in pathological process underlying chronic and neuropathic pain. We hypothesized 100 Hz alleviated Freund’s complete adjuvant (CFA) induced via regulating...
Human colorectal cancer (CRC), a highly malignant and metastatic carcinoma, is resistant to many present anticancer therapies. The inhibition of tumor survival growth through receptor suppression promising way treat CRC. study aimed investigate the effect natural plant triterpenoid, berberine (BBR), on SW480 cells whether its role mediated by Glucose-regulated protein 78 (GRP78). MTT assay, wound healing Annexin V-FITC assay were used measure BBR proliferation, migration, apoptosis cells,...
Abstract Aims Epidemiological studies in patients with neuropathic pain have demonstrated a strong association between and psychiatric conditions such as anxiety. Preclinical clinical work has that electroacupuncture (EA) effectively alleviates anxiety‐like behaviors induced by chronic pain. In this study, potential neural circuitry underlying the therapeutic action of EA was investigated. Methods The effects stimulation on mechanical allodynia animal models spared nerve injury (SNI) were...
Abstract Aims Negative emotions induced by chronic pain are a serious clinical problem. Electroacupuncture (EA) is clinically proven safe and effective method to manage pain‐related negative emotions. However, the circuit mechanisms underlying effect of EA treatment on remain unclear. Methods Plantar injection complete Freund's adjuvant (CFA) was performed establish rat model inflammatory pain‐induced anxiety‐like behaviors. Adeno‐associated virus (AAV) tracing used identify excitatory...
Anxiety is a common comorbidity associated with chronic pain, which results in pain complexification and difficulty treatment. Electroacupuncture (EA) commonly used to treat anxiety. However, the underlying mechanisms of EA effect are largely unknown. Here, we showed that circuitry induces anxiety disorders, can them by regulating such circuitry. Using chemogenetic methods, found activation rostral anterior cingulate cortex (rACC) glutamatergic output thalamus induced disorders control rats....
Neuropathic pain is a common cause of chronic and often accompanied by negative emotions, making it complex difficult to treat. However, the neural circuit mechanisms underlying these symptoms remain unclear. Herein, we present novel pathway associated with comorbid anxiety. Using chemogenetic methods, found that activation glutamatergic projections from rostral anterior cingulate cortex (rACC Glu ) ventrolateral periaqueductal gray (vlPAG) induced both hyperalgesia anxiety-like behaviors in...
Endothelial dysfunction, which includes endothelial oxidative damage and vascular inflammation, is a key initiating step in the pathogenesis of atherosclerosis (AS) an independent risk factor for this disorder. Intracellular chloride channel 1 (CLIC1), novel metamorphic protein, acts as sensor cell oxidation involved inflammation. In study, we hypothesize that CLIC1 plays important role AS. Apolipoprotein E-deficient mice were supplied with normal diet or high-fat high-cholesterol 8 weeks....
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Previous study suggested that toll-like receptor (TLR) signaling pathway contributes to the development and progression of RA. In recent years, acupuncture has become one most vital treatments arthralgia. But little known about mechanisms improving RA by acupuncture.The studied effect electroacupuncture in "Zusanli" "Kunlun" acupoints on expression TLR4, myeloid differentiation factor 88 (MYD88), NF-κB adjuvant rats clarify...
Chronic pain is highly associated with anxiety. Electroacupuncture (EA) effective in relieving and Currently, little known about the neural mechanisms underlying comorbidity of chronic anxiety EA mechanism. This study investigated a potential circuit comorbid mechanisms.
Chronic pain is regarded to be one of the common and refractory diseases cure in clinic. One hundred Hz electroacupuncture (EA) commonly used for inflammatory 2 neuropathic possibly by modulating transient receptor potential vanilloid subtype 1 (TRPV1) or purinergic P2X3 related pathways. To clarify mechanism EA under various conditions pathological pain, rats received a subcutaneous administration complete Freund's adjuvant (CFA) spared nerve injury (SNI) pain. The was performed at...
Electroacupuncture (EA) can effectively modulate pain perception and pain-related negative affect; however, we do not know whether the effect of EA on sensation affect is parallel, or dissociated, interactional. In this study, observed effects anterior cingulate cortex (ACC) lesion primary somatosensory (S1) activation perception, affection, neural oscillation in S1. ACC lesions did but relieved pain-paired aversion. S1 increased anxious behavior. mitigate regardless there an lesion. Chronic...
To observe the expression of GABAA receptor mRNA in different brain regions central nervous system chronic inflammatory pain rats and intervention effect electroacupuncture (EA).A total 48 SPF male SD were randomly divided into a blank control group, model an EA group sham 12 each group. The was established by injecting Freund's complete adjuvant foot. treated with 28 days after establishment. "Housanli" (ST 36) "Kunlun" (BL 60) selected dilatational wave, 2 Hz/100 Hz frequency, 0.5-1.5 mA...