A5072915164- Nanoparticles: synthesis and applications
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Phytochemicals and Medicinal Plants
- Synthesis and biological activity
- Cell death mechanisms and regulation
- Nanoparticle-Based Drug Delivery
- Endoplasmic Reticulum Stress and Disease
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Medicinal Plants and Neuroprotection
- Telomeres, Telomerase, and Senescence
- Moringa oleifera research and applications
- Pancreatic and Hepatic Oncology Research
- Adenosine and Purinergic Signaling
- Autophagy in Disease and Therapy
- Nanotechnology research and applications
- Silk-based biomaterials and applications
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Phytochemical Studies and Bioactivities
- Estrogen and related hormone effects
Maharaja Sriram Chandra Bhanja Deo University
2022-2025
National Institute of Science Education and Research
2025
Homi Bhabha National Institute
2025
The Ohio State University
2020-2023
Bhagwant University
2023
Hi-Tech Medical College & Hospital
2023
Indian Institute of Chemical Biology
2023
National Institute of Technology Rourkela
2015-2021
Ohio University
2020
Academy of Scientific and Innovative Research
2014-2019
The present study demonstrates an economical and eco-friendly method for the synthesis of silver nanoparticles (AgNPs) using wild mushroom Ganoderma sessiliforme. AgNPs was confirmed products characterized by UV-visible spectroscopy, dynamic light scattering spectroscopy X-ray diffraction analysis. Furthermore, Fourier transform infrared (ATR-FTIR) analysis performed to identify viable biomolecules involved in capping active stabilization AgNPs. Moreover, average sizes morphologies were...
An active medicinal component of plant origin with an ability to overcome autophagy by inducing apoptosis should be considered a therapeutically lead pharmacophore control malignancies. In this report, we studied the effect concentration-dependent 3-AWA (3-azido withaferin A) sensitization androgen-independent prostate cancer (CaP) cells which resulted in distinct switching 2 interrelated conserved biological processes, i.e. and apoptosis. We have observed 3 parameters are hallmarks our...
Green-based synthesis of metal nanoparticles using marine seaweeds is a rapidly growing technology that finding variety new applications. In the present study, aqueous extract seaweed, Gracilaria edulis, was employed for metallic without any reducing and stabilizing chemical agents. The visual color change validation through UV-Vis spectroscopy provided an initial confirmation regarding edulis-mediated green synthesized silver nanoparticles. dynamic light scattering studies high-resolution...
Reactive oxygen species (ROS) are a double-edged sword that possesses both beneficial and harmful effects. Although basic research on skin cancer prevention has undergone huge transformation, cases of recurrence with higher rates drug resistance some its drawbacks. Therefore, targeting mitochondria by ROS overproduction provides an alternate approach for anticancer therapy. In the present study, green-synthesized silver nanoparticles (AgNPs) were explored triggering production in A431...
Abstract Epithelial–mesenchymal transition (EMT) in cancer cells drives chemoresistance, yet the molecular events of EMT that underpin acquisition chemoresistance are poorly understood. Here, we demonstrate a loss gemcitabine chemosensitivity facilitated by human equilibrative nucleoside transporter 1 (ENT1) during pancreatic and identify cadherin switching from epithelial (E) to neuronal (N) type, hallmark EMT, contributes this loss. Our findings N-cadherin decreases ENT1 expression,...
Nanoscale copper oxide (CuO NPs) with diameters in the 80–150 nm range has been biosynthesized using lipopeptide biosurfactant derived from Bacillus vallismortis and characterized by XRD FE-SEM. The CuO NPs could be introduced as nanocarrier systems for combination therapy a potential candidate antibacterial, antioxidant, anticancer, anti-diabetic activity. antibacterial activity of was studied incorporating nanoparticles fluorescent antibiotic Ciprofloxacin HCL (CIP) to form CIP@CuO tracked...
Here, we provide evidences that natural product derivative 3-azido Withaferin A (3-AWA) abrogated EMT and invasion by modulating β-catenin localization its transcriptional activity in the prostate as well breast cancer cells. This study, for first time, reveals 3-AWA treatment consistently sequestered nuclear augmented cytoplasmic pool evidenced reducing these Moreover, triggered robust induction of pro-apoptotic intracellular Par-4, attenuated Akt rescued Phospho-GSK3β (by Akt) to promote...
Green synthesis of metallic nanoparticles has lured the world from chemical and physical approaches owing to its rapid, non-hazardous economic aspect production mechanism. In this study, silver (AgNPs) were synthesised using petal extracts Hibiscus rosa-sinensis. The AgNPs displayed characteristic surface plasmon resonance peak at around 421 nm having a mean particle size 76.25±0.17 carried charge -41±0.2 mV. X-ray diffraction patterns typical peaks face centred cubic crystalline silver....
Abstract Epithelial to mesenchymal transitions (EMT) is a preparatory process for cancer cells attain motility and further metastasis distant sites. Majority of DNA damaging drugs have shown develop EMT as one the major mechanisms drug resistance. Here we sought understand resistance/survival instincts during initial phase treatment. We provide tangible evidence stimulation factors in Apc knockout colorectal carcinoma model. Our results implied that CPT-treated cohorts depicted increased...
Green nanotechnology is currently a very crucial and indispensable technology for handling diverse problems regarding the living planet. The concoction of reactive oxygen species (ROS) biologically synthesized silver nanoparticles (AgNPs) has opened new insights in cancer therapy. current investigation caters to concept involvement novel eco-friendly avenue produce AgNPs employing wild endolichenic fungus Talaromyces funiculosus. funiculosus-AgNPs were evaluated with aid UV visible...
This research explores the eco-friendly creation of functional, biocompatible nanomaterials through green chemistry, utilizing natural extracts over chemicals to produce metal and oxide nanoparticles. The study focuses on iron nanoparticles synthesized with Volvariella volvacea (GIONP) evaluates their physical, chemical, biological traits, including anticancer capabilities, against traditionally made IONPs (CIONP). GIONPs, confirmed by UV-visible spectroscopy dynamic light scattering, showed...
The bottom-up synthesis of gold nanoparticles (AuNPs) using Ocimum sanctum essential oil extracts exhibited excellent antimicrobial and therapeutic potential against MCF 7 breast carcinoma through flow cytometry analysis DNA damage studies.