A5066703114- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Ectopic Pregnancy Diagnosis and Management
- Reproductive System and Pregnancy
- Gynecological conditions and treatments
- Endometriosis Research and Treatment
- Reproductive Health and Technologies
- Reproductive Health and Contraception
- Uterine Myomas and Treatments
- Demographic Trends and Gender Preferences
- Hepatitis B Virus Studies
- Blood groups and transfusion
- Sperm and Testicular Function
- Air Quality and Health Impacts
- Genomics and Chromatin Dynamics
- Pluripotent Stem Cells Research
- Renal and related cancers
- Adolescent Sexual and Reproductive Health
- Hepatitis Viruses Studies and Epidemiology
- Neurogenetic and Muscular Disorders Research
- Cardiomyopathy and Myosin Studies
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
First Affiliated Hospital of Zhengzhou University
2016-2025
Compliant Concept
2019
Creative Commons
2018
Zhengzhou University
2014-2015
Huazhong University of Science and Technology
2012
Tongji Hospital
2012
Histone modifications regulate gene expression and development. To address how they are reprogrammed in human early development, we investigated key histone marks oocytes embryos. Unlike that mouse oocytes, the permissive mark trimethylated H3 lysine 4 (H3K4me3) largely exhibits canonical patterns at promoters oocytes. After fertilization, prezygotic genome activation (pre-ZGA) embryos acquire chromatin widespread H3K4me3 CpG-rich regulatory regions. By contrast, repressive H3K27me3...
Recently, two patients with primary ovarian insufficiency (POI) delivered healthy babies after in vitro activation (IVA) treatment followed by auto-transplantation of frozen-thawed tissues.This study sought to report the first case live birth IVA following fresh tissue grafting POI, together monitoring follicle development and serum hormonal changes.This was a prospective observational cohort study.We performed 14 POI mean age 29 years, duration since last menses 3.8 average basal FSH level...
The aim of the present study was to investigate impact serum VD status on IVF outcomes and observe effect deficiency expression endometrial receptivity marker HOXA10. Patients undergoing their first cycles were divided into 3 groups according levels (deficient: <20 ng/mL, insufficient: 20-29.9 ng/mL), replete ≥30 ng/mL). laboratory parameters, implantation rate, clinical pregnancy rate compared among these patient age (≥ 35 years old < old). In addition, HOXA10 analyzed using quantitative...
The potential effects of hyperandrogenism (HA) on pregnancy outcomes among polycystic ovary syndrome (PCOS) patients are still unknown. aim this study was to explore the impact HA miscarriage rate after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment PCOS patients. Women diagnosed with who underwent first autologous IVF/ICSI cycles using gonadotropin-releasing hormone agonist (GnRH-a) protocols for ovarian stimulation during period from January 2016 December 2022...
In order to explore the relationship between endometrial thickness on day of embryo transfer and pregnancy outcomes in frozen-thawed (FET) cycles, we retrospectively analyzed data from 2997 patients undergoing their first FET cycles January 2010 December 2012. All were divided into three groups (Group A, ≤8 mm; Group B, 9–13 C, ≥14 mm) according day. Compared with other two groups, thin A had significantly lower clinical rate (33.4%, 41.3% 45.4%, p < 0.01) live birth (23.8%, 32.2% 34.0%,...
In order to explore the relationship between serum progesterone (P) level on day of human chorionic gonadotrophin (HCG) administration and cumulative live birth rate in patients with different ovarian response during vitro fertilization (IVF), we carried out this retrospective cohort study including a total 4,651 undergoing their first IVF cycles from January 2011 December 2012. All final outcome (4,332 patients) were divided into three groups according response: poor responder (≤5 oocytes,...
The aim of this study was to explore the impact endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst.This observational cohort included a total 3091 undergoing their first embryo transfer (FET) cycles between April 2015 March 2019. Endometrial measured by trans-vaginal ultrasound twice for each patient: day administration, and transfer. recorded.Regardless preparation protocol...
In order to study the impact of procedures IVF/ICSI technology on sex ratio in China, we conducted this multi-center retrospective including 121,247 babies born 93,895 women China. There were 62,700 male and 58,477 female babies, making being 51.8% (Male: Female = 107∶100). univariate logistic regression analysis, was imbalance toward females 50.3% when ICSI preformed compared 47.7% IVF used (P<0.01). The significantly higher males transfers blastocyst (54.9%) thawed embryo (52.4%) with...
In order to explore the impact of endometrial thickness on hCG administration day ongoing pregnancy rate (OPR) in IVF-ET cycles, we retrospectively analyzed data from 10,406 patients undergoing their first IVF cycles with standard gonadotropin releasing hormone analogue (GnRH-a) long protocol. Firstly, were divided into poor (≤ 5 oocytes), medium (6–14 and high (≥ 15 oocytes) ovarian responders based number oocytes retrieved. each group, sub-divided three groups according administration:...
The study was designed to investigate the roles of endometrial thickness (EMT) at day human chorionic gonadotropin (hCG) administration on pregnancy outcomes in a large patient population.This retrospective cohort included 9,952 patients undergoing their first IVF/ICSI with autologous oocytes from January 2011 2015. Patients were divided into three groups based EMT (group A:≤8 mm; group B: 9-14 mm and C:≥15 mm). Live birth rate (LBR), clinical (CPR), early miscarriage (EMR), ectopic (EPR)...
Abstract Background This study aimed to evaluate the cut-off value of anti-Müllerian hormone (AMH) combined with body mass index (BMI) in diagnosis polycystic ovary syndrome (PCOS) and morphology (PCOM). Methods retrospective included 15,970 patients: 3775 women PCOS, 2879 PCOM, 9316 patients as controls. Multivariate logistic regression analysis was used calculate adjusted odds ratios (ORs) 95% confidence intervals (CIs) for AMH. We randomly divided into two data sets. In dataset 1, a...
Polycystic ovary syndrome (PCOS) is linked to obesity, impaired glucose tolerance and diabetes. Recently, studies have found that preptin enhances insulin secretion in rats might play a role the pathogenesis of diabetes PCOS humans. The aim this study was evaluate relationship between PCOS, status, serum level.This conducted university-affiliated hospital from October 2010 August 2011. Anthropometric parameters, sex hormone concentrations, blood pressure, lipid profiles, fasting insulin, 2-h...
Background: What are the trends and figures in treatments involving Assisted Reproductive Technology (ART) mainland China? Method: The Chinese Society of Medicine (CSRM) retrospectively collected analyzed data from 2013 to 2016 28 province China by CSRM ART Data Reporting System. Results: Among 327 centers December 2016, 133 reported 1 211 303 cycles 470 725 infants four year period. Since 2013, total number frozen embryo transfer (FET) cycles, PGD/PGS cycle showed an increasing trend year....
To study the association between ambient air pollutant exposure during follicular phase and in vitro fertilization (IVF) outcomes. A single-center retrospective analysis. Henan Province, China. Patients (n = 6659) living Zhengzhou, Province central China who underwent their first IVF cycle at First Affiliated Hospital of Zhengzhou University 2013 2019 were included for None. The relationships PM2.5, PM10, AQI (Air Quality Index) with outcomes (period I, 85 days before oocyte retrieval;...
To investigate whether the endometrial thickness change ratio from progesterone administration day to blastocyst transfer is associated with pregnancy outcomes in a single frozen-thawed euploid cycle.All patients used natural cycles luteal support for preparation and selected after biopsy preimplantation genetic testing. The was measured by transvaginal ultrasound on day, measured, calculated. According rate of thickness, were divided into three groups: compaction group, non-change group...
Background Male sperm DNA fragmentation (SDF) may be associated with assisted reproductive technology (ART) outcomes, but the impact of SDF on occurrence aneuploid-related miscarriage remains controversial. Methods Genome-wide single-nucleotide polymorphism-based chromosomal microarray analysis was performed 495 miscarried chorionic villus samples undergone IVF/ICSI treatment from Reproductive Medicine Center First Affiliated Hospital Zhengzhou University. assessed using chromatin structure...
Background: Several studies have shown that newborns conceived through the ART procedures were associated with an increased incidence of preterm delivery compared to those spontaneously regardless type procedure. The aim study was explore risk factors for birth (PTB) in assisted reproductive technology. Method: In this single center retrospective cohort study, a total 23,111 singleton from January 2010 December 2018 included. primary outcome birth, defined as live before 37 weeks’ gestation....