A5048001811- RNA Interference and Gene Delivery
- Hydrogen's biological and therapeutic effects
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Thermal Regulation in Medicine
- Immune Response and Inflammation
- Nanoplatforms for cancer theranostics
- Acute Ischemic Stroke Management
- Nanoparticle-Based Drug Delivery
- Liver Disease and Transplantation
- Hearing Loss and Rehabilitation
- Barrier Structure and Function Studies
- Transition Metal Oxide Nanomaterials
- Drug-Induced Hepatotoxicity and Protection
- Medicinal Plants and Bioactive Compounds
- Gas Sensing Nanomaterials and Sensors
- Advanced Materials and Mechanics
- Hearing, Cochlea, Tinnitus, Genetics
- Amyotrophic Lateral Sclerosis Research
- Spinal Cord Injury Research
- Sepsis Diagnosis and Treatment
- Ga2O3 and related materials
- Genomics, phytochemicals, and oxidative stress
- Sports injuries and prevention
Yiwu Science and Technology Research Institute
2024-2025
Fudan University
2014-2025
Xi'an Jiaotong University
2009-2025
Third Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
Second Affiliated Hospital of Xi'an Jiaotong University
2024-2025
Chongqing Medical University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Shanghai Jiao Tong University
2021-2024
Beijing Tsinghua Chang Gung Hospital
2024
Acetaminophen- (APAP-) induced hepatic injury is an important clinical challenge. Oxidative stress, inflammation, apoptosis, and endoplasmic reticulum stress (ERS) contribute to the pathogenesis. Methane has potential anti-inflammatory, antioxidant, antiapoptotic properties. This project was aimed at studying protective effects relative mechanisms of methane in APAP-induced liver injury. In vivo experiment, C57BL/6 mice were treated with APAP (400 mg/kg) induce followed by methane-rich...
Abstract Thermochromic window develops as a competitive solution for carbon emissions due to comprehensive advantages of its passivity and effective utilization energy. How further enhance the solar modulation ( $${\triangle T}_{{{{{{{\rm{sol}}}}}}}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mrow> <mml:mo>△</mml:mo> <mml:mi>T</mml:mi> </mml:mrow> <mml:mi>sol</mml:mi> </mml:msub> </mml:math> ) thermochromic windows while ensuring high luminous transmittance...
Abstract Aims Neutrophil extracellular traps (NETs) have been implicated in thrombotic diseases. There is no definitive explanation for how NETs form during acute ischemic strokes (AIS). The purpose of our study was to investigate the potential mechanism and role formation AIS process. Methods As well as 45 healthy subjects, patients with had ELISA tests performed detect NET markers. Expression high-mobility group box 1 (HMGB1) on platelet microvesicles (PMVs) analyzed by flow cytometry...
Caspase-11 detection of intracellular lipopolysaccharide mediates non-canonical pyroptosis, which could result in inflammatory damage and organ lesions various diseases such as sepsis.Our research found that lactate from the microenvironment acetaminophen-induced acute liver injury increased levels, enhanced gasdermin D activation accelerated macrophage lead to exacerbation injury.Further experiments unveiled inhibits ubiquitination by reducing its binding NEDD4, a negative regulator...
Abstract Aims Diabetic cardiomyopathy (DCM) is a major cause of mortality in patients with diabetes, and the potential strategies for treating DCM are insufficient. Melatonin (Mel) has been shown to attenuate DCM, however, underlying mechanism remains unclear. The role vascular endothelial growth factor-B (VEGF-B) little known. In present study, we aimed investigate whether Mel alleviated via regulation VEGF-B explored its mechanisms. Methods results We found that significantly cardiac...
The recently emerged remote epitaxy technique, utilizing 2D materials (mostly graphene) as interlayers between the epilayer and substrate, enables exfoliation of crystalline nanomembranes from expanding range potential device applications. However, has been so far applied to a limited material systems, owing need stringent growth conditions avoid graphene damaging, therefore remained challenging for synthesis oxide nanomembranes. Here, we demonstrate epitaxial an nanomembrane (vanadium...
Increasing evidence suggests that oxidative stress plays an essential role during carcinogenesis. However, the underlying mechanism between and carcinogenesis remains unknown. Recently, microRNAs (miRNAs) are revealed to be involved in response This study aims identify miRNAs hepatocellular carcinoma (HCC) cells which might involve response. An integrated analysis of miRNA expression signature was performed by employing robust rank aggregation (RRA) method, four (miR‐34a‐5p, miR‐1915‐3p,...
Sepsis is a systemic inflammatory response syndrome caused by dysregulated host to infection. Peroxisome proliferator-activated receptor gamma (PPARγ) exerts anti-inflammatory and antioxidative properties. To investigate the potential effects of PPARγ on sepsis-induced liver injury determine related mechanisms, C57BL/6 male mice were subjected cecal ligation puncture (CLP) create sepsis model which was treated with GW1929 or GW9662 upregulate downregulate expression PPARγ. We found that...
Sepsis‐induced acute kidney injury (AKI) is a severe complication of sepsis and an important cause mortality in septic patients. Previous investigations showed that methane had protective properties against different diseases animal models. This study aimed at investigating whether methane‐rich saline (MRS) has effect sepsis‐induced AKI. Sepsis was induced wild‐type C57BL/6 mice by cecal ligation puncture (CLP), the were divided into three groups: sham control group (sham), surgery with...
Abstract Probing the onset of micellization, or determining critical micelle concentration (CMC), is crucial importance while remains to be challenged by growing demand for extraordinary sensitivity and accuracy. Although fluorometry has attracted wide attention owing its superiority in simplicity over other methods, presence fluctuation background fluorescence conventional fluorescent probes undermine accuracy CMC determination. Herein, a series novel without at below absolute...
The nuclear erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway plays an essential role in the cellular antioxidant and anti-inflammatory responses. Spinal cord injury (SCI) results a massive release of inflammatory factors free radicals, which seriously compromise nerve recovery axon regeneration. In this study, we examined efficacy probucol on responses functional after SCI by activating Nrf2/ARE pathway. We also investigated mechanism inflammation is...
iRGD (internalizing RGD) with high affinity to αν integrins was reported enhance tumor penetrability by binding neuropilin-1 (NRP-1). Based on our previous study, chitosan surface-modified poly (lactide-co-glycolides) nanoparticles (PLGA/CS NPs), loaded carmustine (BCNU) and its sensitizer (O6-benzylguanine, BG) showed stronger anti-tumor effect than free drugs. In present PLGA/CS NPs (NPs) core-shell structure were prepared modified or mPEG. F98, C6 U87 cell lines different receptors levels...
The nuclear factor E2-related 2 (Nrf2)/antioxidant response element signaling pathway plays a substantial role in preventing oxidative stress-related diseases. Aspirin has been shown to exert several pharmacological effects by inducing the expression of heme oxygenase-1 (HO-1) protein. However, aspirin on spinal cord injury (SCI) have rarely studied. Therefore, we sought investigate neuroprotective after SCI. We employed contusion model Sprague-Dawley rats, and was administered...
Fluorescent dyes are extensively utilized in various fluorescence imaging techniques. However, many existing modification strategies could not balance the performance (such as brightness, photostability, water solubility, and permeability) of fluorophores. Herein we report a general strategy to enhance donor–acceptor-type fluorophores by introducing azetidine-containing heterospirocycles commonly used fluorophore scaffolds. Such turned out be way develop high-quality