A5053943546- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phagocytosis and Immune Regulation
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- COVID-19 Clinical Research Studies
- Retinoids in leukemia and cellular processes
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Acute Myeloid Leukemia Research
- interferon and immune responses
- Traditional Chinese Medicine Analysis
- Advanced biosensing and bioanalysis techniques
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
- Blood properties and coagulation
- Lung Cancer Research Studies
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- S100 Proteins and Annexins
- Extracellular vesicles in disease
Ningbo First Hospital
2021-2025
Shihezi University
2025
Xinjiang Production and Construction Corps
2025
Tianjin University of Traditional Chinese Medicine
2021-2025
Ningbo University
2023-2024
Ningbo University Affiliated Hospital
2023-2024
First Affiliated Hospital of Harbin Medical University
2011-2020
Harbin Medical University
2011-2020
Third Affiliated Hospital of Harbin Medical University
2018-2019
Ministry of Education of the People's Republic of China
2016
Despite the presence of neutrophil extracellular traps [NETs] in inflamed colon having been confirmed, role NETs, especially circulating progression and thrombotic tendency inflammatory bowel disease [IBD] remains elusive. We extended our previous study to prove that NETs constitute a central component prothrombotic state IBD.In all 48 consecutive patients with IBD were studied. Acute colitis was induced by treatment C57BL/6 mice 3.5% dextran sulphate sodium [DSS] drinking water for 6 days....
Abstract Aims Neutrophil extracellular traps (NETs) have been implicated in thrombotic diseases. There is no definitive explanation for how NETs form during acute ischemic strokes (AIS). The purpose of our study was to investigate the potential mechanism and role formation AIS process. Methods As well as 45 healthy subjects, patients with had ELISA tests performed detect NET markers. Expression high-mobility group box 1 (HMGB1) on platelet microvesicles (PMVs) analyzed by flow cytometry...
Summary Inflammatory bowel disease (IBD)-associated thromboembolic event often lacks precise aetiology. The aim of this study was to investigate the contribution phosphatidylserine (PS) exposure and neutrophil extracellular traps (NETs) towards hypercoagulable state in IBD. We demonstrated that levels PS exposed MPs sources MP-origin, platelets, erythrocytes, leukocytes cultured endothelial cells (ECs) were higher IBD groups than healthy controls using flow cytometry confocal microscopy....
Sepsis is invariably accompanied by altered coagulation cascade; however, the precise role of phosphatidylserine (PS) in inflammation-associated coagulopathy sepsis has not been well elucidated. We explored possibility exposed PS on microparticles (MPs), blood cells, as endothelium, and defined its procoagulant activity (PCA) sepsis. PS-positive MPs cells were detected flow cytometry, while PCA was assessed with clotting time, purified complex, fibrin formation assays. Plasma levels PS+...
Lung cancer stem cells have the ability to self-renew and are resistant conventional chemotherapy. MicroRNAs (miRNAs) regulate control expression function of many target genes; therefore, miRNA disorders involved in pathogenesis human diseases, such as cancer. However, effects dysregulation on tumour stemness drug resistance not been fully elucidated. miR-181b has reported be a suppressor is associated with drug-resistant non-small cell lung Cancer (CSC)-like properties were tested by...
Abstract Background and Aims Heart failure (HF) is a leading cause of mortality worldwide characterized by significant co-morbidities dismal prognosis. Neutrophil extracellular traps (NETs) aggravate inflammation in various cardiovascular diseases; however, their function mechanism action HF pathogenesis remain underexplored. This study aimed to investigate the involvement novel VWF-SLC44A2-NET axis progression. Methods NET levels were examined patients with mouse models transverse aortic...
Abstract The mechanisms that eliminate activated platelets in inflammation-induced disseminated intravascular coagulation (DIC) micro-capillary circulation are poorly understood. This study explored an alternate pathway for platelet disposal mediated by endothelial cells (ECs) through phosphatidylserine (PS) and examined the effect of clearance on procoagulant activity (PCA) sepsis. Platelets septic patients demonstrated increased levels surface activation markers apoptotic vesicle...
The mechanisms contributing to an increased risk of thrombosis in uremia are complex and require clarification. There is scant morphological evidence membrane-dependent binding factor Xa (FXa) Va (FVa) on endothelial cells (EC) vitro. Our objectives were confirm that exposed phosphatidylserine (PS) microparticle (MP), EC, peripheral blood cell (PBC) has a prothrombotic role uremic patients provide visible PS-dependent prothrombinase assembly We found had more circulating MP (derived from PBC...
Abstract Despite the high efficacy and safety of arsenic trioxide (ATO) in treating acute promyelocytic leukemia (APL) eradicating APL leukemia-initiating cells (LICs), mechanism underlying its selective cytotoxicity remains elusive. We have recently demonstrated that undergo a novel cell death program, termed ETosis, through autophagy. However, role ETosis ATO-induced LIC eradication unclear. For this study, we evaluated effects ATO on contributions drug-induced to eradication. In NB4...
Summary Abundant senescent neutrophils traverse the vascular compartment and may contribute to pathologic conditions. For example, they become procoagulant when undergoing apoptosis thrombosis or inflammation. Our previous studies demonstrated a dominant clearance pathway in which can be phagocytosed by liver macrophages. The aim of this study was explore an alternate neutrophil endothelial cells. Phagocytosis cells performed using various experimental approaches including flow cytometry,...
Acute promyelocytic leukemia (APL) cells exhibit disrupted regulation of cell death and differentiation, therefore the fate these leukemic is unclear. Here, we provide first evidence that a small percentage APL undergo novel pathway by releasing extracellular DNA traps (ETs) in untreated patients. Both NB4 stimulated with serum had nuclear budding vesicles filled chromatin leaked to space when membranes ruptured. Using immunofluorescence, found undergoing ETosis extruded lattice-like...
Lactate, a marker of tumor metabolic reprogramming, maintains the acidic microenvironment and also affects metabolism function immune cells. SLC16A3 is responsible for extracellular transport lactate, which key component glycolysis. However, role in infiltration immunosuppression lung cancer largely unknown. Our study explored therapeutic prognostic value predicting checkpoint efficacy cancer.SLC16A3 expression was evaluated with TCGA database. Kaplan-Meier analysis performed survival rates....
The procoagulant status of patients with non-small cell lung cancer (NSCLC) after chemotherapy is poorly characterized and the role platelets in hypercoagulative state NSCLC unknown. aim this study was to evaluate activity (PCA) before chemotherapy. subjects were 52 newly diagnosed NSCLC. had decreased clotting time compared healthy subjects, thrombin-antithrombin complex increased 2.5-fold Platelets enhanced phosphatidylserine (PS) exposure, shortened coagulation as well thrombin fibrin...
Autophagy plays a complicated role in tumorigenesis, and the effects of autophagy drug resistance have not been fully known. The aim this study was to evaluate activity lung cancer cells derived from different origins explore mechanism regulating tyrosine kinase inhibitor (TKI) resistance. We found basal level had no significant increase resistant H1650 H1975 compared with sensitive HCC827 PC9 cells. After erlotinib treatment, enhanced threefold but little Inhibiting 3-MA increased apoptosis...
Hypercoagulability in gastric cancer is a common complication and major contributor to poor prognosis. This study aimed determine procoagulant activity of blood cells microparticles (MPs) patients. Phosphatidylserine-positive MPs, their properties particular, were assessed 48 patients 35 healthy controls. platelets, leukocytes, MPs with tumor-node-metastasis stage III/IV significantly higher than those I/II or Moreover, was increased compared the controls, as indicated by shorter clotting...