A5085859464- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Photoacoustic and Ultrasonic Imaging
- Signaling Pathways in Disease
- Cardiac electrophysiology and arrhythmias
- RNA modifications and cancer
- Ultrasound and Hyperthermia Applications
- Cardiac Fibrosis and Remodeling
- Advanced Nanomaterials in Catalysis
- Mesenchymal stem cell research
- Photodynamic Therapy Research Studies
- Pancreatic and Hepatic Oncology Research
- Synthesis of Organic Compounds
- Inflammatory Biomarkers in Disease Prognosis
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Ion channel regulation and function
- Synthesis and biological activity
- Cancer Risks and Factors
- Ion Channels and Receptors
- Cardiomyopathy and Myosin Studies
- Advances in Cucurbitaceae Research
- Colorectal Cancer Surgical Treatments
- Multicomponent Synthesis of Heterocycles
Harbin Medical University
2015-2024
Harbin University
2013
First Affiliated Hospital of Harbin Medical University
2011
Riso Kagaku (Japan)
2009
Abstract Cuproptosis and ferroptosis hold great promise for overcoming apoptotic resistance in liver cancer based on their unique metal‐driven cell death modalities. However, insufficient intracellular copper iron concentration, complicated tumor microenvironment (TME), unclear cross‐regulatory mechanisms between cuproptosis ferroptosis, severely restrict the therapeutic performance. Herein, copper‐doped hollow Prussian blue (CHP) nanozymes are rationally designed loading photosensitizer...
Identifying the key factor mediating pathological cardiac hypertrophy is critically important for developing strategy to protect against heart failure. Bone morphogenetic protein-4 (BMP4) a mechanosensitive and proinflammatory gene. In this study, we investigated role of BMP4 in hypertrophy, apoptosis, fibrosis experimentally hypertrophy. The vivo models were induced by pressure-overload angiotensin (Ang) II constant infusion mice, vitro model was Ang exposure cultured cardiomyocytes....
Abstract Ferroptosis and cuproptosis are emerging modes of programmed cell death have been increasingly used to eliminate tumor cells. However, converting ferroptosis/cuproptosis into effective treatments is challenging because the inherent antioxidant plasma membrane repair systems inefficient copper ion delivery. Herein, an engineered doping method developed encapsulate ZnO 2 with Cu 2+ ‐doped ZIF‐8 modify surface by transferrin (Tf). In resulting @Cu/ZIF‐8‐Tf nanosystem, Tf specifically...
Abstract Bone marrow-derived mesenchymal stem cells (BMSCs) have emerged as a promising therapeutic strategy for cardiovascular disease. However, there is no evidence so far that BMSCs can heal pathological myocardial hypertrophy. In this study, were indirectly cocultured with neonatal rat ventricular cardiomyocytes (NRVCs) in vitro or intramyocardially transplanted into hypertrophic hearts vivo. The results showed isoproterenol (ISO)-induced typical characteristics of prevented by the...
Abstract Hypoxia‐inducible factor‐1 alpha (HIF‐1α) is a central transcriptional regulator of hypoxic response. The present study was designed to investigate the role HIF‐1α in mild hypoxia‐induced cardiomyocytes hypertrophy and its underlying mechanism. Mild hypoxia (MH, 10% O 2 ) caused cultured neonatal rat cardiac myocytes, which accompanied with increase mRNA accumulation protein nuclei. Transient receptor potential canonical (TRPC) channels including TRPC3 TRPC6, except for TRPC1, were...
Bone marrow mesenchymal stem cells (BMSCs) are capable of homing to and repair damaged myocardial tissues. Apoptosis BMSCs in response various pathological stimuli leads the attenuation healing ability BMSCs. Plenty evidence has shown that elevated homocysteine level is a novel independent risk factor cardiovascular diseases. The present study was aimed investigate whether may induce apoptosis its underlying mechanisms. Here we uncovered significantly inhibited cellular viability...
Cuproptosis is a regulated cell death form associated with tumor progression, clinical outcomes, and immune response. However, the role of cuproptosis in pancreatic adenocarcinoma (PAAD) remains unclear. This study aims to investigate implications cuproptosis-related genes (CRGs) PAAD by integrated bioinformatic methods validation.Gene expression data information were downloaded from UCSC Xena platform. We analyzed expression, mutation, methylation, correlations CRGs PAAD. Then, based on...
Cucurbitacin B (CuB), the active component of a traditional Chinese herbal medicine, Pedicellus Melo, has been shown to exhibit antitumor and anti-inflammation effects, but its role in tumor angiogenesis, key step involved growth metastasis, molecular mechanism are unknown. Tumor angiogenesis is one hallmarks development malignant neoplasias metastasis. Effective targeting area interest for cancer therapy. Here, we demonstrated that CuB significantly inhibited human umbilical vascular...
It is important to explore effective treatment for liver cancer. Photodynamic therapy (PDT) a novel technique treat cancer, but its clinical application obstructed by limited depth of visible light penetration into tissue. The near-infrared (NIR) photosensitizer potential solution the limitations PDT deep tumor tissue treatment.We aimed investigate 808 nm NIR light-excited UCNPs@mSiO2-Ce6-GPC3 nanocomposites in cancer.In our study, upconversion nanoparticles (UCNPs) were simultaneously...
Abstract Objective The purpose of the study is to construct meaningful nomogram models according independent prognostic factor for metastatic pancreatic cancer receiving chemotherapy. Methods This retrospective and consecutively included 143 patients from January 2013 June 2021. receiver operating characteristic (ROC) curve with area under (AUC) utilized determine optimal cut‐off value. Kaplan–Meier survival analysis, univariate multivariable Cox regression analysis are exploited identify...
Down-regulation of Kv4.3 K+ channels commonly occurs in multiple diseases, but the understanding regulation and role pathological conditions are limited. HEK (human embryonic kidney)-293T cells derived from HEK-293 which transformed by expression large T-antigen. In present study, comparing HEK-293T cells, we find that express more transcription factor Sp1 (specificity protein 1) than cells. Inhibition with decoy oligonucleotide reduces channel Transfection pN3-Sp1FL vector increases results...
Shensong Yangxin capsules (SSYX) are an effective traditional Chinese medicine that has been used to treat coronary heart disease clinically. The present study aimed establish whether SSYX prevent ischemic arrhythmias in rats, and explore the underlying mechanisms. Male rats were pretreated with distilled water, amiodarone for one week. Acute myocardial ischemia (AMI) was performed induce arrhythmias. incidence severity of evaluated. action potential, transient outward K+ current (Ito)...
Hypertension is a major risk factor for stroke and cardiovascular events in clinic, which accompanied by the abnormality of vascular tone endothelial dysfunction small artery. Here we report that Kang Le Xin (KLX), novel anthraquinones compound, could reduce blood pressure underlying mechanisms involves KLX induces endothelium-dependent vasodilation. significantly decreases arterial spontaneous hypertensive rats (SHR), contractile reactivity superior mesenteric artery to phenylephrine...
A series of novel N(3),N(11)-bis(2-hydroxyethyl)-14-aryl-14H-dibenzo[a,j]xanthenes-3,11-dicarboxamide, three N(3),N(11)-bis(2-hydroxyethyl)-14-aryl-14H-dibenzo[a,j]xanthene-3,11-dimethanamine derivatives and their intermediates 14-aryl-14H-dibenzo[a,j]xanthenes-3,11-dicarboxylic acid, were synthesized, the structures which characterized by (1)H-NMR, (13)C-NMR, high resolution (HR)-MS, IR spectra. The antitumor activities these molecules evaluated on five cancer cell lines. results in vitro...
Annexin A2 (ANXA2) has been well known to associate with the progress of malignant tumor. However, biological behavior ANXA2 in gastric cancer (GC) remains unclear. We made a hypothesis transcriptome level from TCGA datasets. Then, we used immunohistochemical staining quantify expression protein GC tissues compared adjacent tissues. Quantitative real-time PCR and western blot were for analyzing human (SGC-7901, MKN-45, BGC-823, AGS) cell lines. investigated effect lentivirus-mediated...
5-Aminolevulinic acid hydrochloride (ALA)-mediated sonodynamic therapy (SDT) had anti-tumour effect on pancreatic cancer cells. Hence, ALA loaded lipid/poly(lactic-co-glycolic acid) (PLGA) microbubbles (MBs)-mediated SDT for has great potential. The average size of ALA-lipid MBs and ALA-PLGA was about 3.0 µm. two kinds good biocompatibility to normal HPDE6-C7 cells were not toxic Compared with ALA-induced SDT, a statistically significant decrease in cell viability observed lipid/PLGA...