A5102847522- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Nanoplatforms for cancer theranostics
- Natural product bioactivities and synthesis
- Diabetes Management and Research
- Mesenchymal stem cell research
- Nanoparticle-Based Drug Delivery
- Traditional Chinese Medicine Analysis
- Atherosclerosis and Cardiovascular Diseases
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Cardiac Arrhythmias and Treatments
- MicroRNA in disease regulation
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Drug Transport and Resistance Mechanisms
- Cardiovascular Function and Risk Factors
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Ultrasound and Hyperthermia Applications
- Aortic Disease and Treatment Approaches
- Bone Metabolism and Diseases
- Cell Adhesion Molecules Research
- Ginseng Biological Effects and Applications
- Atrial Fibrillation Management and Outcomes
Qingdao University
2013-2025
Qingdao Municipal Hospital
2016-2025
Shandong University
2024-2025
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2024
Zhejiang Pharmaceutical College
2017-2023
China Medical University
2019-2022
Xinqiao Hospital
2022
Dalian Medical University
2021
Affiliated Hospital of Qingdao University
2021
Shantou University
2020
Pathological cardiac hypertrophy induced by adrenergic overactivation can subsequently develop to heart failure which remains as a leading cause of mortality worldwide.Tanshinone IIA is lipid-soluble pharmacologically active compound extracted from the rhizome Chinese herb Salvia miltiorrhiza, well-known traditional medicine used for treatment cardiovascular disorders.However, little know about effect Tanshinone on hypertrophy.The present study was aimed investigate whether prevents...
Background/Aims: Doxorubicin is a widely used chemotherapeutic agent, but its clinical use restricted because of high risk cardiotoxicity. Bone marrow-derived mesenchymal stem cells (BMSCs) may repair ischaemically damaged myocardium through transdifferentiation and paracrine action. The aim this study to investigate if doxorubicin causes the apoptosis BMSCs in turn impairs healing ability. Methods: were exposed doxorubicin, cell was determined by western blot stainings. Results: reduced...
Abstract Bone marrow-derived mesenchymal stem cells (BMSCs) have emerged as a promising therapeutic strategy for cardiovascular disease. However, there is no evidence so far that BMSCs can heal pathological myocardial hypertrophy. In this study, were indirectly cocultured with neonatal rat ventricular cardiomyocytes (NRVCs) in vitro or intramyocardially transplanted into hypertrophic hearts vivo. The results showed isoproterenol (ISO)-induced typical characteristics of prevented by the...
The purpose of this study was to investigate the effect FNDC5 expression levels in hepatocellular carcinoma on phenotypic changes macrophages tumor tissues. In study, we established an vitro co-culture system cells and macrophages. Then performed overexpression or knockdown gene observe level THP-1 And conclusions obtained assay were further validated by a subcutaneous tumorigenic nude mice model. Our findings suggest that elevated lead increased M2 phenotype decreased M1 This may be...
Bone marrow mesenchymal stem cells (BMSCs) are capable of homing to and repair damaged myocardial tissues. Apoptosis BMSCs in response various pathological stimuli leads the attenuation healing ability BMSCs. Plenty evidence has shown that elevated homocysteine level is a novel independent risk factor cardiovascular diseases. The present study was aimed investigate whether may induce apoptosis its underlying mechanisms. Here we uncovered significantly inhibited cellular viability...
Periostin, an extracellular matrix protein, plays a significant role in adverse cardiac remodeling. However, no report has documented the function of periostin left ventricular remodeling streptozototin (STZ)-induced diabetic rats. The aim present study was to observe expression Wistar rat's myocardium cardiomyopathy (DCM) and effect valsartan on it.Immunohistochemistry, real-time polymerase chain reaction, Western blot analysis were used determine degree location periostin, transforming...
Background Studies have shown that ESCRT genes affect cell aging, immune environment, and tumors. BRCA was used to explore its effects on tumor prognosis therapy. Methods The data sets of Cancer Genome Atlas (TCGA), Genome-Tissue Expression Plan (GTEX), Human Protein Mapping (HPA), Gene Omnibus (GEO), Clinical Proteomic Tumor Analysis Consortium (CPTAC), R software package, bioinformatics methods were mine the potential carcinogenic ESCRT, including expression level, prognostic value, value...
Introduction: Irisin is a newly identified cytokine that has gained increasing attention because of its potential therapeutic applications in metabolic diseases and human cancers. Recently, accumulating evidence indicates irisin plays an important role the development metastasis various tumors. The aim this study was to evaluate effects underlying mechanisms on malignant growth pancreatic cancer cells. Materials methods: anti-proliferative effect examined using CCK-8 assay. Irisin-induced...
Osteoporosis is a common bone disorder where the declined mass far more than normal physiological status and usually associated with enhanced fracture risk, reduced strength even deteriorated quality of life. Recent studies showed that statins could exert beneficial effects on bones via promoting osteoblastic activity mediated by increased expression morphogenetic protein 2 also suppressing osteoclast proliferation. In this study, we developed atorvastatin-loaded tetracycline-poly (ethylene...
To investigate the relationship between hypoxia-inducible factor 1-alpha (HIF-1α), Twist family BHLH transcription 1 (TWIST-1), and β1 integrin (ITGB-1) expression tumor stiffness, evaluate performance of HIF-1α, TWIST-1, ITGB-1 alone in combination with Ki-67 for predicting pathological responses to neoadjuvant chemotherapy (NACT) breast cancer (BC).This was a prospective cohort study 104 BC patients receiving NACT. Tumor stiffness oxygen score (OS) were evaluated before NACT by shear-wave...
ABSTRACT Sweroside, a natural secoiridoid glycoside derived from various medicinal plants, is known for its anti‐tumor, anti‐inflammatory, and hepatoprotective properties. However, pharmacological significance not fully supported by low systemic exposure. In this study, de novo strategy was proposed to investigate the metabolism of sweroside in rats, including drug administration, sample pretreatment, ultra‐high‐performance liquid chromatography/Quadrupole‐Exactive mass spectrometry data...