A5101560470- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Sulfur Compounds in Biology
- Porphyrin and Phthalocyanine Chemistry
- Photoacoustic and Ultrasonic Imaging
- Advanced Nanomaterials in Catalysis
- Analytical Chemistry and Sensors
- Crystallography and molecular interactions
- RNA modifications and cancer
- Lipid Membrane Structure and Behavior
- Electrochemical sensors and biosensors
- Carbon and Quantum Dots Applications
- Forest, Soil, and Plant Ecology in China
- Photoreceptor and optogenetics research
- Cancer-related molecular mechanisms research
- Electrochemical Analysis and Applications
- Photochromic and Fluorescence Chemistry
- Cancer, Hypoxia, and Metabolism
- Organic Light-Emitting Diodes Research
- S100 Proteins and Annexins
Guangzhou Medical University
2025
Pearl River Hydraulic Research Institute
2025
Technical Institute of Physics and Chemistry
2015-2024
Chinese Academy of Sciences
2015-2024
Harbin Medical University
2022-2023
Second Affiliated Hospital of Harbin Medical University
2022-2023
ZheJiang Academy of Agricultural Sciences
2023
Hangzhou Medical College
2022
Zhejiang Provincial People's Hospital
2022
University of Chinese Academy of Sciences
2006-2019
[reaction: see text] A new sensing mechanism based on C=N isomerization, which shows a very significant fluorescence enhancement to the metal cations in simple and efficient way, is demonstrated. coumarin derivative (L) containing group was designed as an example for illustration. The free ligand L almost nonfluorescent due isomerization of double bond excited state. However, solution about 200-fold increase quantum yield (about 30%) upon addition Zn(ClO4)2.
A ratiometric fluorescence sensor based on pyrene was designed for selective detection of heparin in HEPES (N-(2-hydroxyethyl)piperazine-N'-ethanesulfonic acid) buffer and serum sample. Pyrene long-chain alkanes were linked through bisquaternary functionality the which could interact with via supramolecular assembly. fluorescent signal change can be observed because specific monomer-excimer conversion is modulated by self-assembly heparin. Upon addition heparin, excimer emission at 489 nm...
The development of near-infrared fluorescent probes with low pKa, high selectivity, photostability, and sensitivity for lysosomal pH detection is great importance. In the present work, we developed a novel probe (Lyso-hNR) based on rhodamine derivative. Lyso-hNR showed fast, highly sensitive, selective fluorescence response to acidic caused by H+-induced structure changes from nonfluorescent spirolactam form emissive open-ring form. displays significant enhancement at 650 nm (over 280-fold)...
Two series of new tetracyclic pyrazolo[3,4-b]pyridine-based coumarin chromophores were synthesized through a facile reaction between 3-aldehyde-7-diethylaminocoumarin (5) or 3-acetyl-7-diethylaminocoumarin (6) and 5-aminopyrazole derivatives (7) in one-pot procedure. Different condensed products obtained from compounds 5 6, the potential mechanism was studied using with 5-amino-1-phenylpyrazole (7a). The molecular structures characterized by NMR HRMS confirmed X-ray diffraction....
A series of deep red fluorescent dyes (CR1 to CR3) was developed via introduction a coumarin moiety into the rhodamine molecular skeleton. The novel possessed individual advantages and derivatives, emission wavelength extended region (>650 nm) due extension fused-ring conjugate structure simultaneously. To illustrate its value, we designed conveniently synthesized bioimaging (CR1E CR3E) by esterification CR1 CR3, which could selectively stain mitochondria. They were superior MitoTrackers for...
3-Phenylthiophene-based water-soluble copolythiophenes (CPT1) were designed for colorimetric and fluorometric detection of lipopolysaccharide (LPS). The sensor (CPT1-C) shows a high selectivity to LPS in the presence other negatively charged bioanalytes as well an extreme sensitivity with limit at picomolar level, which is lowest ever achieved among all synthetic sensors available thus far. Significantly, sensing interaction can be apparently observed by naked eyes, presents great advantage...
Lipid droplets (LDs) are crucial organelles used to store lipids and participate in lipid metabolism cells. The abnormal aggregation polarity change of LDs associated with the occurrence diseases, such as steatosis. Herein, polarity-sensitive probe TBPCPP a donor-acceptor-π-acceptor (D-A-π-A) structure was designed synthesized. has large Stokes shift (∼220 nm), excellent photostability, high LD targeting, considerable two-photon absorption (TPA) cross-section (∼226 GM), enabling deep imaging...
Abstract Antimicrobial photodynamic therapy (aPDT) has emerged as an appealing therapeutic option against biofilm infections. However, effectively penetrating the dense barrier of and anchoring bacteria to achieve elimination wound healing under hypoxic environments remains a challenge for aPDT. Herein, three type I/II Hypocrellin B (HB)‐cationic photosensitizers (HB‐P, HB‐TP, HB‐TTP) are designed based on multi‐cationic long chains molecular engineering strategy. With increasing number...
A novel fluorescent chemosensor (compound 1) containing aminonaphthol, which selectively recognizes fluoride anion with high sensitivity, was synthesized. The fluorescence of compound 1 quenched rapidly by ion, and a new peak at longer wavelength emerged concurrently, constituted the signature for detection. mechanism exciplex formation proposed interesting observation.
A new series of intramolecular charge transfer (ICT) molecules were synthesized by attaching various strong electron-withdrawing groups to a triphenylamine backbone. Relationships between chemical structures and optoelectronic properties these compounds investigated with X-ray diffraction, cyclic voltammetry, absorption spectroscopy, density functional theory calculations. It is shown that the exhibit intensive ICT interactions leading substantial extension their spectral response, which may...
Two coumarin-based boron complexes (HBN and MBN) with aggregation-induced emission were designed synthesized. The photophysical properties of the investigated in different solvents solid state. Results showed that inhibited C═N isomerization by N,O-chelated BF2 caused significant enhancement fluorescence THF. In particular, displayed red-shifted emissions (>60 nm) mixed CH3CN water because charge-transfer enhancement. state, bright red appeared at 650 nm (620 nm), a Stokes shift 170 nm....
Natural products show high potential for clinical translation because of their specific biological activities and molecular structure diversities. Sonosensitizers that originate from natural play a crucial role as anti-inflammatory anticancer agents. Herein, hypocrellin-derivative nanoparticles (APHB NPs) were constructed synchronous near-infrared fluorescence (NIR FL) imaging sonodynamic therapy (SDT) deep-seated tumors in vivo. The prepared APHB NPs exhibit excellent water solubility, FL...
Abstract Carbon dots (CDs), a kind of phototheranostic agent with the capability simultaneous bioimaging and phototherapy [i.e., photodynamic therapy (PDT) or photothermal (PTT)], have received considerable attention because their remarkable properties, including flexibility for surface modification, high biocompatibility, low toxicity photo‐induced activity malignant tumor cells. Among numerous carbon sources, it has been found that natural biomass are good candidates preparation CD agents....
A coumarin-derived complex, Hg2L2, was reported as a highly sensitive and selective probe for the detection of mercapto biomolecules in aqueous solution. The addition Cys to 99% solution Hg2L2 resulted rapid remarkable fluorescence OFF–ON (emission at 525 nm) due ligand-exchange reaction with L coordinated Hg2+. increased can be completely quenched by Hg2+ recovered again subsequent Cys. Such circle repeated least 10 times alterative indicating that it used convertible reversible...
A novel red (λmaxem = 632 nm) fluorescent probe based on 3-hydroxyflavone was designed and synthesized for thiol recognition with high sensitivity excellent selectivity. Application of the selective detection intracellular thiols has been successfully demonstrated.