A5100385591- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Sulfur Compounds in Biology
- Gas Sensing Nanomaterials and Sensors
- Analytical Chemistry and Sensors
- Advanced Chemical Sensor Technologies
- Porphyrin and Phthalocyanine Chemistry
- Photochromic and Fluorescence Chemistry
- Sulfur-Based Synthesis Techniques
- Electrochemical Analysis and Applications
- Microbial Metabolic Engineering and Bioproduction
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Analytical Chemistry and Chromatography
- Advanced Sensor and Energy Harvesting Materials
- Advanced Proteomics Techniques and Applications
- Biofuel production and bioconversion
- Water Quality Monitoring and Analysis
- Electrochemical sensors and biosensors
- Peptidase Inhibition and Analysis
- Plant biochemistry and biosynthesis
- Carbon and Quantum Dots Applications
- Enzyme Production and Characterization
- Lipid metabolism and biosynthesis
Xinjiang University
2023-2025
Huazhong Agricultural University
2025
Jilin University
2024
Beijing Institute of Fashion Technology
2020-2024
Chinese Academy of Sciences
2012-2022
Dalian Institute of Chemical Physics
2019-2022
ZheJiang Institute For Food and Drug Control
2020
Beijing University of Chemical Technology
2020
Technical Institute of Physics and Chemistry
2009-2018
Shanghai Jiao Tong University
2018
A novel lysosome-targeting ratiometric fluorescent probe (CQ-Lyso) based on the chromenoquinoline chromorphore has been developed for selective and sensitive detection of intracellular pH in living cells. In acidic media, protonation quinoline ring CQ-Lyso induces an enhanced intramolecular charge transfer (ICT) process, which results large red-shifts both absorption (104 nm) emission (53 spectra forms basis a new fluorescence sensor. This efficiently stains lysosomes with high Pearson's...
A C(3)-symmetric Schiff-base example of the new simple, low cost, highly water soluble, and sensitive turn-on fluorescent Zn(2+) chemosensor is described. The sensor was successfully applied to detection intracellular Zn(2+). Moreover, could also serve as a potential recyclable component in sensing materials. Notably, color change so obvious that all recycling process can be seen clearly by naked eye.
The development of near-infrared fluorescent probes with low pKa, high selectivity, photostability, and sensitivity for lysosomal pH detection is great importance. In the present work, we developed a novel probe (Lyso-hNR) based on rhodamine derivative. Lyso-hNR showed fast, highly sensitive, selective fluorescence response to acidic caused by H+-induced structure changes from nonfluorescent spirolactam form emissive open-ring form. displays significant enhancement at 650 nm (over 280-fold)...
A series of deep red fluorescent dyes (CR1 to CR3) was developed via introduction a coumarin moiety into the rhodamine molecular skeleton. The novel possessed individual advantages and derivatives, emission wavelength extended region (>650 nm) due extension fused-ring conjugate structure simultaneously. To illustrate its value, we designed conveniently synthesized bioimaging (CR1E CR3E) by esterification CR1 CR3, which could selectively stain mitochondria. They were superior MitoTrackers for...
By introducing the tetrahydroquinoxaline group as electron donor to enhance intramolecular charge transfer effect, we deliberately designed a coumarin derivative, TQC-HClO, serve two-photon ratiometric fluorescent probe for imaging hypochlorous acid in cells and zebra fish with good sensitivity high selectivity. TQC-HClO displayed an obvious absorbance cross-section (over 100 GM 800–840 nm), large Stokes shifts (159 173 fluorescence change from orange (λmaxem = 583 nm) red 650 response acid.
A highly sensitive and selective 1,8-naphthyridine-based fluorescent chemodosimeter for Zn2+ has been designed, synthesized, applied to the detection of intracellular Zn2+.
Thiorhodamine-based chemodosimeter A, a disulfide linked dimer, was designed for Hg2+ recognition by virtue of the strong affinity mercury sulfur. Spectroscopic results reveal that A exhibits real-time responses, and high sensitivity selectivity in comparison to other cations. These properties are mechanistically ascribed transfer from rhodamine spirolactam thiazoline-derived open-ring rhodamineviaHg2+ induced desulfurization. The vitro living cells pretreated with examined, showing...
A water-soluble rhodamine-based derivative (L) has been rationally designed for selective recognition of Al3+ in aqueous medium with good sensitivity. The addition to the solution L induces a remarkable fluorescence enhancement along obvious color change detected by naked eye, due ring-opening mechanism rhodamine spirolactam, which proved single crystal diffraction analyses directly. recognizing behavior investigated both experimentally and computationally. Furthermore, fluorescent probe can...
A coumarin-derived complex, Hg2L2, was reported as a highly sensitive and selective probe for the detection of mercapto biomolecules in aqueous solution. The addition Cys to 99% solution Hg2L2 resulted rapid remarkable fluorescence OFF–ON (emission at 525 nm) due ligand-exchange reaction with L coordinated Hg2+. increased can be completely quenched by Hg2+ recovered again subsequent Cys. Such circle repeated least 10 times alterative indicating that it used convertible reversible...
A highly fluorescent chemosensor based on 1,8-naphthyridine with high sensitivity and selectivity toward Ni2+/Cu2+ over other cations both in aqueous solution a wide pH range (4–10) cellular environments was developed. Counteranions such as acetate, sulfate, nitrate, perchlorate have no influence the detection of metal ions. Ethylenediamine showed situ-prepared Cu2+ complex Ni2+ complex, which can be applied to distinguish Cu2+. The Ni2+-induced fluorescence on–off mechanism revealed...
A new quinine derivative PQ, bearing pyrenyl as a fluorophore, was prepared to recognize heparin in aqueous solution. PQ exhibits good selectivity and sensitivity for over other biological molecules. Upon binding with heparin, shows typical excimer emission peaked at 489 nm along weak monomer 376 nm. Moreover, also performance detect the serum.
Using the selective cleavage of 2,4-dinitrobenzenesulfonamide by benzenethiols, a 1,8-naphthalimide-based OFF-ON fluorescent probe was synthesized and its application demonstrated.
3-Phenylthiophene-based water-soluble copolythiophenes (CPT9) were designed for colorimetric and fluorometric detection of lysophosphatidic acid (LPA) based on electrostatic interaction, hydrophobic hydrogen bonding. Other negatively charged species gave nearly no interference, the limit reached to 0.6 μM, which is below requisite limits LPA in human plasma samples. The appealing performance CPT9 was demonstrated originate from multipoint interaction-induced conformational change conjugated...