A5102625122- Spinal Cord Injury Research
- Autophagy in Disease and Therapy
- Land Use and Ecosystem Services
- Sleep and Wakefulness Research
- Signaling Pathways in Disease
- Conservation, Biodiversity, and Resource Management
- Advanced Measurement and Metrology Techniques
- Adenosine and Purinergic Signaling
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Syndromes and Imprinting
- Peroxisome Proliferator-Activated Receptors
- Circadian rhythm and melatonin
- Connexins and lens biology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Traditional Chinese Medicine Analysis
- Chromatography in Natural Products
- Advanced Glycation End Products research
- Wnt/β-catenin signaling in development and cancer
- Adhesion, Friction, and Surface Interactions
- Neuroscience of respiration and sleep
- Retinal Development and Disorders
- Vehicular Ad Hoc Networks (VANETs)
- Spinal Hematomas and Complications
Nanjing University
2024-2025
University of Chinese Academy of Sciences
2023-2025
Shanghai Institute of Technical Physics
2025
Peking University
2024
Huzhou University
2023-2024
Peking University People's Hospital
2024
Institute of Wetland Research
2024
Beijing Jiaotong University
2023
Guangxi University of Chinese Medicine
2023
Zhejiang Chinese Medical University
2023
Abstract Statins exhibit neuroprotective effects after spinal cord injury ( SCI ). However, the molecular mechanism underlying these remains unknown. This study demonstrates that hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin (Simv) exhibits on neuronal apoptosis and supports functional recovery in a rat model by activating Wnt/β‐catenin signaling pathway. In specific, Simv administration significantly up‐regulated expression of low density lipoprotein receptor‐related...
To study the specific therapeutic effect of zinc on spinal cord injury (SCI) and its protective mechanism. The effects ions neuronal cells were examined in a mouse SCI model vitro. In vivo, neurological function was assessed by Basso Mouse Scaleat (BMS) at 1, 3, 5, 7, 10, 14, 21, 28 days after injury. number neurons histomorphology observed nissl staining hematoxylin-eosin (HE). chromatin mitochondrial structure detected transmission electron microscopy (TEM). expression nuclear factor...
The nuclear erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway plays an essential role in the cellular antioxidant and anti-inflammatory responses. Spinal cord injury (SCI) results a massive release of inflammatory factors free radicals, which seriously compromise nerve recovery axon regeneration. In this study, we examined efficacy probucol on responses functional after SCI by activating Nrf2/ARE pathway. We also investigated mechanism inflammation is...
Atorvastatin, a lipid-lowering medication, provides neuroprotective effects, although the precise mechanisms of action remain unclear. Our previous studies confirmed activated autophagy following spinal cord injury, which was conducive to recovery neurological functions. We hypothesized that atorvastatin could also activate after and subsequently improve A rat model injury established based on Allen method. Atorvastatin (5 mg/kg) intraperitoneally injected at 1 2 days injury. At 7...
The nuclear factor E2-related 2 (Nrf2)/antioxidant response element signaling pathway plays a substantial role in preventing oxidative stress-related diseases. Aspirin has been shown to exert several pharmacological effects by inducing the expression of heme oxygenase-1 (HO-1) protein. However, aspirin on spinal cord injury (SCI) have rarely studied. Therefore, we sought investigate neuroprotective after SCI. We employed contusion model Sprague-Dawley rats, and was administered...
Berberine exerts neuroprotective effect in neuroinflammation and neurodegeneration disease. However, berberine acute spinal cord injury is yet to be elucidated. Herein, we investigated the of (SCI). Sprague-Dawley rats were subjected SCI by an intraperitoneal injection post-injury. The neurobehavioral recovery, cytokines pro-inflammatory factors (TNF-α IL-1β), autophagy-related proteins (LC3B, ATG16L, ATG7), apoptosis-related protein cleaved caspase-3 determined. expressions 2',...
The mechano-responsiveness of osteocytes is critical for maintaining bone health and associated with a reduced oxidative stress defense, yet the precise molecular mechanisms remain incompletely understood. Here, we address gap by investigating epigenetic reprogramming that drives osteocyte responses to mechanical loading. We found overall remodeling antioxidant response under loading identified NRF2, key transcription factor in response, which plays vital role osteocytes. results showed...
In the detection of gravitational waves in space, during science phase mission, point-ahead angle mechanism (PAAM) serves to steer a laser beam compensate for generated by relative motion two spacecrafts (SCs) approximately 10 s flight time will take from one SC reach distant three million kilometers away. The Tilt-to-length (TTL) noise budget PAAM is constrained less than 8 pm/Hz within frequency range 1 mHz Hz. This constraint requires that measurement interferometer remains below this...
Receptor for advanced glycation end products (RAGE) signaling is involved in a series of cell functions after spinal cord injury (SCI). Our study aimed to elucidate the effects RAGE on neuronal recovery SCI. In vivo, rats were subjected SCI with or without anti-RAGE antibodies micro-injected into lesion epicenter. We detected Nestin/RAGE, SOX-2/RAGE and Nestin/MAP-2 by Western blot immunofluorescence (IF). found that neural stem cells (NSCs) co-expressed significantly activated SCI, while...
Abstract The intake of high dietary fat has been correlated with the progression age‐related macular degeneration (AMD), affecting function retinal pigment epithelium through oxidative stress. A high‐fat diet (HFD) can lead to lipid metabolism disorders, excessive production circulating free fatty acids, and systemic inflammation by aggravating degree Deletion G‐protein‐coupled receptor (RGR‐d) identified in drusen. In this study, we investigated how RGR‐d exacerbates AMD‐like changes under...
In space gravitational wave detection, the inter-satellite link-building process requires a type of steering mirror to achieve point-ahead angle pointing. To verify that background noise does not drown out signal, this paper designed laser heterodyne interferometer specifically measure optical path difference mirror. Theoretically, impact and position jitter is analyzed, which called tilt-to-length (TTL) coupling. This based on design concept equal-arm length. vacuum (10−3 Pa), vibration...
Nischarin (NISCH) is a cytoplasmic protein known to serve an inhibitory role in breast cancer cell apoptosis, migration and invasion. Recently, NISCH has been reported be involved the regulation of spinal cord injury (SCI). However, molecular mechanism still unclear. Oxidative stress contributes tissue apoptosis during development various diseases, including SCI. The aim present study was investigate induced by oxidative PC12 cells. H2O2 used establish model Apoptosis levels were examined...
Millettia speciosa (M. speciosa) Champ (MSC) is a healthy food type with medicinal and edible homology, which now considered clinically significant anti-rheumatoid arthritis medicine. However, there currently no standardized or generally accepted research strategy by we can assess M. speciosa. Thus, it essential to develop novel theories, strategies evaluation methods for the scientific quality control of Herein, our use ultra-high-performance liquid chromatography (UPLC)-MS/MS analysis...
Nischarin (NISCH) is a key protein functioning as molecular scaffold and thereby hosting interactions with several partners. Here, we aimed to investigate whether NISCH downregulation could protect rat pheochromocytoma (PC12) cells against oxidative stress-induced injury using model of cell induced by hydrogen peroxide (H 2 O ). Cell viability was evaluated 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. apoptosis rate flow cytometry. The expressions apoptosis-related...
Abstract The development of alternative medications for urate-lowering therapies is imperative patients that are intolerant to current treatments. Despite GWAS have identified hundreds loci associated with serum urate levels, the mechanistic understanding and discovery drug targets remain difficult. This difficulty arises from multiple-independent-associations challenge in genomic studies complex diseases as hyperuricemia. Here, we introduced a locus-specific stratification (LSS) gene...
Eukaryotic genes contain introns that are removed by the spliceosomal machinery during mRNA maturation. Introns impose a huge energetic burden on cell; therefore, they must play an essential role in maintaining genome stability and/or regulating gene expression. Many (> 50%) Plasmodium parasites predicted introns, including 5' and 3' untranslated regions (UTR). However, roles of UTR expression malaria remain unknown. In this study, episomal dual-luciferase assay was developed to evaluate...