A5043634468- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- Occupational and environmental lung diseases
- Vitamin D Research Studies
- Gastrointestinal disorders and treatments
- Aluminum toxicity and tolerance in plants and animals
- Cancer Mechanisms and Therapy
- Folate and B Vitamins Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Silicon Effects in Agriculture
- Neutropenia and Cancer Infections
- Biochemical and Molecular Research
- Cancer, Hypoxia, and Metabolism
Changzhi Medical College
2013-2024
Changzhi Medical College Peace Hospital
2013-2020
Safety and efficacy of neoadjuvant chemoradiotherapy (nCRT) vs chemotherapy (nCT) for treatment locally advanced esophageal squamous cell carcinoma (ESCC) remain uncertain given lack high-level clinical evidence.To compare safety long-term survival nCRT followed by minimally invasive esophagectomy (MIE) with that nCT MIE patients ESCC.A prospective, multicenter, open-label, randomized trial compared ESCC. From January 1, 2017, to December 31, 2018, 264 ESCC stages from cT3 T4aN0 1M0 were...
•The CMISG1701 trial assessed the safety and efficacy of nCRT versus nCT followed by MIE for locally advanced bulky ESCC.•The strategy could not improve survival significantly compared with strategy.•The best neoadjuvant therapy ESCC remains a pending issue. BackgroundNeoadjuvant is recommended esophageal cancer, but optimal unclear. We aimed to evaluate chemoradiotherapy (nCRT) chemotherapy (nCT) minimally invasive esophagectomy (MIE) squamous cell carcinoma (ESCC).Patients methodsEligible...
Pancreatic cancer (PC) is an extremely malignant tumor with low survival rate. Effective biomarkers and therapeutic targets for PC are lacking. The roles of circular RNAs (circRNAs) in cancers have been explored various studies, however more work needed to understand the functional specific circRNAs. In this study, we explore role mechanism circ_0035435 (termed circCGNL1) PC.
The dysregulation of lipid metabolism poses a significant health threat, necessitating immediate dietary intervention. Our previous research unveiled the prebiotic-like properties theabrownin. This study aimed to further investigate theabrownin-gut microbiota interactions and their downstream effects on using integrated physiological, genomic, metabolomic, transcriptomic approaches. results demonstrated that theabrownin significantly ameliorated dyslipidemia, hepatic steatosis, systemic...
This multicenter, randomized phase III trial evaluated the efficacy and safety of perioperative camrelizumab (an anti-PD-1 antibody) plus low-dose rivoceranib (a VEGFR-2 inhibitor) S-1 oxaliplatin (SOX) (SOXRC), high-dose SOX (SOXR), alone for locally advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma.
Exploring the efficacy and safety of perioperative chemotherapy on patients with AGC at different clinical pathological stages.A phase III randomized, multicenter, trial comparing adjuvant (arm A) or S-1 plus oxaliplatin (SOX, arm B), capecitabine (XELOX, C) was initiated in T3/4, node + gastric cancer (unclear). Each patient received an 8-cycle (3 weeks for one cycle). Group arms B C two cycles preoperatively, six postoperatively. Primary endpoints were R0 resection rate DFS, secondary...
Neoadjuvant chemoradiation is not recommended as an approach for treatment of esophageal squamous cell carcinoma due to its significant postoperative mortality. However, it assumed the combination neoadjuvant with minimally invasive esophagectomy (MIE) may reduce mortality, which can revive preoperative chemoradiation. No randomized controlled studies comparing plus MIE chemotherapy have been performed so far. The present trial initiated obtain valid information whether yields better...
The aim of the present study was to compare effects bone marrow‑derived mesenchymal stem cells (BMSCs) transplanted via portal vein or tail on liver injury in rats with cirrhosis. BMSCs were isolated from rat marrow and labeled green fluorescent protein (GFP). Then, injected into vein. Two weeks after transplantation, three each group sacrificed test distribution GFP serum levels alanine aminotransferase (ALT), aspartate (AST) albumin. Six later, remaining sacrificed, ALT, AST, albumin,...
BACKGROUND:MicroRNAs (miRNAs) have been widely recognized as essential regulators in human cancers, including colorectal cancer (CRC). Whether miR-769 is implicated CRC progression remains elusive. The present study aimed to determine the function of CRC. MATERIAL AND METHODS:MiR-769 expression tissues and adjacent normal were measured by quantitative real-time polymerase chain reaction (qRT-PCR) situ hybridization. Kaplan-Meier curve analysis was utilized association between prognosis...
Pancreatic cancer (PC) is a fatal malignancy, threatening human health in worldwide. Long non-coding RNAs (lncRNAs) have been acknowledged to be essential regulators various biological processes of cancers. However, the role some novel lncRNAs PC remain explored. In this study, we focused on function and molecular mechanism lncRNA linc-UROD (also named TCONS_00002016 or XLOC_000166) PC. The expression was found upregulated cells. results loss-of-function assays demonstrated that knockdown...
Experimental studies have determined the chemopreventive effects of vitamin D against esophageal squamous cell carcinoma (ESCC); however, results from epidemiological are not yet well established. The current study aimed to evaluate associations between plasma levels and variants on metabolic-related genes with risks for ESCC. A hospital-based case-control was performed. Five hundred eighty-two ESCC patients 569 controls were recruited in a Northern Chinese population. Common...
Esophageal squamous cell carcinoma (ESCC) is the predominant histological type of esophageal cancer in China and has an extremely poor prognosis. Circulating free DNA (cfDNA) plasma heat shock protein 90alpha (Hsp90a) are two novel noninvasive biomarkers for diagnosis prognostic prediction several types cancer. However, to best our knowledge, roles ESCC still unknown.Here, we recruited 93 primary patients detected concentrations markers at different time points, including 1-3 days...
The aim of this study was to explore the association C20orf54 functional single nucleotide polymorphism (SNP) with susceptibility esophageal squamous cell carcinoma (ESCC) in a northern China population. SNP genotyped by direct sequencing 240 cancer patients and 198 controls China. results showed that drinking status, family history ESCC, body mass index have great influence on risk developing ESCC. overall genotype frequencies ESCC significant difference healthy (χ2 = 8.06, P 0.018). By...
<b><i>Summary</i></b><b><i>Objective: </i></b>The aim of the present study was to explore association functional single-nucleotide polymorphism (SNP) rs3746804 in C20orf54 with susceptibility esophageal squamous cell carcinoma (ESCC). <b><i>Methods: </i></b>SNP detected by direct sequencing 434 ESCC patients and 554 healthy controls from Shanxi Henan Provinces China, geographically a high incidence area for ESCC. The...
ABSTRACT Vitamin C has re-emerged as a promising anticancer agent. This study attempts to analyze the differential gene expression of profiles GSE11919 look for some clues, and most significant cell cycle pathway caused by vitamin was identified integrated bioinformatics analysis. Inspired this, we investigated effect treatment on gastric carcinoma cells detection cycle, apoptosis, autophagy. significantly elevated percentage at G0/G1 phase, whereas S phase decreased. Meanwhile, resulted in...
The aim of the present study was to investigate expression fibulin-2 and β-catenin in gastric cancer tissues association mutual regulation. Forty-nine cases specimens obtained via surgical resection Pathology Department Heping Hospital Affiliated Changzhi Medical College from March 2013 August 2017 were collected. levels 49 para-carcinoma detected quantitative polymerase chain reaction immunohistochemistry. correlation proteins Spearman's analysis. protein with clinicopathological indexes...
Gastric cancer (GC) is one of the most prevalent malignant tumors in world and has an extremely poor prognosis. Regulator calcineurin 1 ( RCAN1 ), a known tumor suppressor various cancers, undefined role proliferation metastasis GC. Primary paired normal gastric tissues were collected from 77 patients with GC for evaluating mRNA levels 3 transcripts. Kaplan–Meier survival curves Cox regression analysis used to assess prognostic value transcripts, select variables nomogram. The isoform...