A5047100994- Pancreatic and Hepatic Oncology Research
- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ectopic Pregnancy Diagnosis and Management
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Endometriosis Research and Treatment
- Hepatitis B Virus Studies
- Gestational Trophoblastic Disease Studies
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Monoclonal and Polyclonal Antibodies Research
- Maternal and fetal healthcare
- Cancer Research and Treatments
- Metastasis and carcinoma case studies
- Neuroblastoma Research and Treatments
- Uterine Myomas and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Viral Infections and Outbreaks Research
- Genital Health and Disease
- Angiogenesis and VEGF in Cancer
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
Shanghai Changzheng Hospital
2025
Zhejiang Provincial People's Hospital
2016-2024
West China Hospital of Sichuan University
2024
First Institute of Oceanography
2023-2024
Ministry of Natural Resources
2023-2024
Qingdao University of Science and Technology
2024
Sidney Kimmel Comprehensive Cancer Center
2019-2024
Johns Hopkins University
2019-2024
Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy necessitates optimization and maintenance of activated effector T cells (Teff). We prospectively collected applied multi-omic analyses to paired pre- post-treatment PDAC specimens in a platform neoadjuvant study granulocyte-macrophage colony-stimulating factor-secreting allogeneic vaccine (GVAX) ± nivolumab (anti-programmed cell death protein 1 [PD-1]) uncover sensitivity resistance mechanisms. show that GVAX-induced tertiary...
Immunotherapy has demonstrated a limited clinical efficacy in approximately 5% of cholangiocarcinoma. The main challenges for an effective immunotherapy response cholangiocarcinoma arise from the tumor microenvironment, which is poorly understood.
Radiotherapy is hypothesized to have an immune-modulating effect on the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) sensitize it anti-PD-1 antibody (a-PD-1) treatment. We collected paired pre- and posttreatment specimens from a clinical trial evaluating combination treatment with GVAX vaccine, a-PD-1, stereotactic body radiation (SBRT) following chemotherapy for locally advanced PDACs (LAPC). With resected different neoadjuvant therapies as comparisons, effector...
In Brief OBJECTIVE: To estimate the prevalence of lymph node involvement in women with primary mucinous ovarian carcinomas. METHODS: A retrospective study was performed patients carcinomas evaluated at a single institution between 1985 and 2007. gynecologic oncology pathologist all cases. Patients tumors low malignant potential metastatic to ovary from other sites were excluded. RESULTS: identified (n=107). All underwent surgery. At time surgery, 93 (87%) had that grossly appeared be...
This cross-sectional study aimed to assess the knowledge, practice and attitude towards HPV vaccination among college students in Beijing, China. Furthermore, factors influencing were analyzed. The data collected via self-administered anonymous questionnaires completed by 884 who recruited from a random sample at Peking University China between September December 2018. In total, 72.6% of participants had previously heard but insufficient knowledge about vaccine. level was significantly...
<h3>Background</h3> Immune checkpoint inhibitors are not effective for pancreatic ductal adenocarcinoma (PDAC) as single agents. Vaccine therapy may sensitize PDACs to inhibitor treatments. Annexin A2 (ANXA2) is a pro-metastasis protein, previously identified relevant PDAC antigen that expressed by GM-CSF-secreting allogenic whole tumor cell vaccine (GVAX) induce an anti-ANXA2 antibody response in patients with PDAC. We hypothesized ANXA2-targeting approach only provokes immune but also...
Wounds can lead to skin and soft tissue damage their improper management may the growth of pathogenic bacteria at site injury. Identifying better ways promote wound healing is a major unmet need biomedical materials with ability are urgently needed. Here, we report thermosensitive black phosphorus hydrogel composed nano-loaded drug silver sulfadiazine (SSD) chitosan for healing. The has temperature-sensitive properties enables continuous release SSD under near-infrared irradiation achieve...
Abstract Liposomal irinotecan has shown promising antitumor activity in patients with advanced or metastatic pancreatic ductal adenocarcinoma (PDAC) who have undergone prior gemcitabine-based therapies. This randomized, double-blind, parallel-controlled, multicenter phase 3 study (NCT05074589) assessed the efficacy and safety of liposomal HR070803 combined 5-fluorouracil (5-FU) leucovorin (LV) this patient population. Patients unresectable, locally advanced, PDAC had previously received...
This multicenter, randomized phase III trial evaluated the efficacy and safety of perioperative camrelizumab (an anti-PD-1 antibody) plus low-dose rivoceranib (a VEGFR-2 inhibitor) S-1 oxaliplatin (SOX) (SOXRC), high-dose SOX (SOXR), alone for locally advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma.
// Qinyuan Liao 1, 2, * , Wei Liu Yang Fulin Wang 4 Chong 2 Jingxuan Zhang 3 Ming Chu Dongyang Jiang Lin Xiao Wenwei Shao Zhengzuo Sheng 1 Xia Tao 5 Lei Huo 6 C. Cameron Yin 7 Youhui 8 Gregory Lee 9 Jing Huang Zihai Li 10 Xiaoyan Qiu Department of Immunology, School Basic Medical Sciences, Peking University, Beijing, 100191, China University Center for Human Disease Genomics, Key Laboratory Ministry Health, Pathology, Chinese PLA General Hospital, 100853, Gynecology, First 100034, Division...
Background: Laparoscopic pancreaticoduodenectomy (LPD) may have potential minimal invasive advantages for selected patients in limited center. However, few studies analyzed the learning curve. This study aimed to analyze curve of this procedure at a large volume set, and share our experience surmount it. Methods: All prospectively maintained data consecutive LPDs was reviewed retrospectively. The procedures were performed by single surgeon. Patients divided into four groups according staged...
The purpose of this retrospective study was to evaluate the safety and efficacy uterine artery embolization (UAE) followed by curettage for conservative management cervical pregnancy.Retrospective review.Peking University First Hospital.Patients with pregnancy diagnosed trans-vaginal ultrasound at Peking Hospital between January 2003 December 2014.We retrospectively reviewed clinical background outcomes patients who underwent UAE prevention massive vaginal bleeding removal gestational tissue...
Super-enhancers (SEs) are expansive cis-regulatory elements known for amplifying oncogene expression across various cancers. However, their role in cervical cancer (CC), a remarkable global malignancy affecting women, remains underexplored. Here we applied integrated epigenomic and transcriptomic profiling to delineate the distinct SE landscape CC by analyzing paired tumor normal tissues. Our study identifies tumor-specific at EFNA1 locus that drives CC. Mechanically, region contains...
Amis Chemotherapy-induced hepatotoxicity (CIH) is a significant concern in colorectal cancer (CRC) patients treated with the CAPEOX (capecitabine and oxaliplatin) regimen. Identifying predictive factors for CIH crucial clinical management. Patients Methods This study analyzed tissue (CRT), plasma, urine samples from CRC patients. Differentially expressed metabolites (DEMs) across these tissues were integrated multi-omics analysis, models susceptibility developed. An independent set of 75...
The integration of AI and big data has revitalized precise teaching. Knowledge graphs, driven by algorithms, structure knowledge integrate teaching resources, offering more content for graduate education. Applied to teaching, they can solve the problems generalized difficulty in meeting individual student needs traditional modes. This paper takes "Principles Education" course as an example. It builds applies considers needs, proposes a model based on graphs. aims optimize educational...
Testing emerging technologies involves the evaluation of biologic plausibility, technical efficacy, clinical effectiveness, patient satisfaction, and cost-effectiveness. The objective this study was to select an effective classification algorithm for optical spectroscopy as adjunct colposcopy obtain preliminary estimates its accuracy detection CIN 2 or worse. We recruited 1,000 patients from screening prevention clinics 850 at two comprehensive cancer centers a community hospital. Optical...
Background: Metabolomics has demonstrated its potential in the early diagnosis, drug safety evaluation and personalized toxicology research of various cancers. Objectives:We aim to screen for diagnostic capecitabine-related adverse effect (CRAE) biomarkers from urinary endogenous metabolites Chinese colorectal cancer (CRC) patients.Methods: The metabolic profiles 139 CRC patients 50 non-neoplastic controls were analyzed using ultra-high-performance liquid chromatography combined with...
The formation of leaf polarity directly determines the development spreading and type, affects physiological functions photosynthesis, transpiration stress resistance plants. Many famous Chinese teas are highly dependent on morphological characteristics size tea leaves. To date, there have been few reports establishment type development. plant-specific transcription factor YABBY family gene has reported to be involved in growth. Herein we describe isolation functional characterization genes...
Laparoscopic distal pancreatectomy (LDP) is a safe and reliable treatment for tumors in the body tail of pancreas. Postoperative pancreatic fistula (POPF) common complication surgery. Despite improvement mortality, rate POPF still remains high unsolved. To identify risk factors after laparoscopic pancreatectomy, clinicopathological variables on 120 patients who underwent LDP with stapler closure were retrospectively analyzed. Univariate multivariate analyses performed to POPF. The overall...
<h3>Objective:</h3> To study the clinicopathological characteristics of Lynch syndrome-associated endometrial carcinoma in China. <h3>Methods:</h3> Twenty-seven patients who fulfilled Amsterdam criteria II were classified as having (group A), and 331 without a family history cancer sporadic B). <h3>Results:</h3> There 81 malignancies 27 families with carcinoma, including colorectal (24.7%), (21.0%), liver (12.3%), stomach (9.9%), lung (6.2%), breast (6.2%) cancers. Mean age at time diagnosis...
Pancreatic ductal adenocarcinoma (PDA) is renowned for high rates of metastasis and poor survival. Its notoriously dense fibrotic stroma contributes to chemoresistance. Stromal signaling in PDA recognized its multiple roles regulating tumor invasion metastasis. However, no stromal biomarker which can predict survival exists. Annexin A2 (AnxA2) was formerly identified as a metastasis-associated protein tumoral overexpression associated with In this study, we examined AnxA2 expression the...