A5013951309- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Rice Cultivation and Yield Improvement
- Plant biochemistry and biosynthesis
- GABA and Rice Research
- Ginseng Biological Effects and Applications
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Advanced Proteomics Techniques and Applications
- Natural product bioactivities and synthesis
- Plant Gene Expression Analysis
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Studies
- Microbial Natural Products and Biosynthesis
- Food composition and properties
- Plant responses to water stress
- Saffron Plant Research Studies
- Advanced Database Systems and Queries
- Phytochemistry and Biological Activities
- Agriculture, Soil, Plant Science
- Berberine and alkaloids research
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Alkaloids: synthesis and pharmacology
- Gut microbiota and health
Shanghai University of Traditional Chinese Medicine
2020-2025
Yunnan Agricultural University
2025
Hainan Medical University
2023-2024
Hainan General Hospital
2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2023-2024
Jiangsu Academy of Agricultural Sciences
2020-2024
Heilongjiang University of Chinese Medicine
2013-2022
University of Mississippi
2018-2020
Yangzhou University
2018-2020
Sinotech Genomics (China)
2020
Summary Salvianolic acids (SA), such as rosmarinic acid (RA), danshensu (DSS), and their derivative salvianolic B (SAB), etc. widely existed in Lamiaceae Boraginaceae families, are of interest due to medicinal properties the pharmaceutical industries. Hundreds studies past decades described that 4‐coumaroyl‐CoA 4‐hydroxyphenyllactic (4‐HPL) common substrates biosynthesize SA with participation synthase (RAS) cytochrome P450 98A (CYP98A) subfamily enzymes different plants. However, our recent...
Indica-japonica hybrid rice (Oryza sativa L.) cultivars showed high yield potential and poor tasting quality when compared with common japonica cultivars. Large panicle is a prominent factor of for indica-japonica cultivars, the weight varies greatly among different It important to research on grain In this study, two types were used relation quality. The yields heavy weights significantly higher than that medium cooking eating starch properties type evaluated. Yongyou 6715 (medium panicle)...
Recent explosion of biological data brings a great challenge for the traditional methods. With increasing scale large sets, much advanced tools are required depth interpretation problems. As rapid-developing technology, metabolomics can provide useful method to discover pathogenesis diseases. This study was explored dynamic changes metabolic profiling in cells model and Balb/C nude-mouse prostate cancer, clarify therapeutic mechanism berberine, as case study. Here, we report findings...
Mechanical pot-seedling transplanting is an innovatively developed method that has the potential to replace mechanical carpet-seedling transplanting. However, initial machine lacked optimized density spacing and limited yield for japonica rice. Therefore, ascertaining by wide-narrow rows appropriate formation grain quality of rice great importance high-quality production. Field experiments were conducted using two cultivars Nanjing 9108 5055 under three methods in 2016 2017: with row (K,...
The important antimalarial drug artemisinin is biosynthesized and stored in Artemisia annua glandular trichomes the content correlates with trichome density; however, factors affecting development are largely unknown. Here, we demonstrate that A. R2R3 MYB transcription factor TrichomeLess Regulator 1 (TLR1) negatively regulates development. In annua, TLR1 overexpression lines had 44.7%-64.0% lower density 11.5%-49.4% contents TLR1-RNAi 33%-93.3% higher 32.2%-84.0% compared non-transgenic...
Protecting haploid pollen and spores against UV-B light high temperature, 2 major stresses inherent to the terrestrial environment, is critical for plant reproduction dispersal. Here, we show flavonoids play an indispensable role in this process. First, identified flavanone naringenin, which serves defend damage, sporopollenin wall of all vascular plants tested. Second, found that flavonols are present spore/pollen protoplasm euphyllophyte tested these scavenge reactive oxygen species...
Abstract Screening the active compounds of herbal medicines is importance to modern drug discovery. In this work, an integrative strategy was established discover effective and their therapeutic targets using Phellodendri Amurensis cortex (PAC) aimed at inhibiting prostate cancer as a case study. We found that PAC could be inhibited growth xenograft tumours cancer. Global constituents serum metabolites were analysed by UPLC-MS based on chinmedomics analysis method, total 54 peaks in spectrum...
A multi-omics approach could yield in-depth mechanistic insights. Here, we performed an integrated analysis of miRNAome, proteome and metabolome, aimed to investigate the underlying mechanism active product geniposide in ethanol-induced apoptosis. We found that integrative meta-analysis identified 28 miRNAs, 20 proteins 7 metabolites significantly differentially expressed, respectively. Further extensively regulated multiple metabolism pathways most important related pathway was citrate...
Metabolomics has been shown to be an effective tool for biomarker screening and pathway characterization disease diagnosis. Metabolic characteristics of hepatocellular carcinoma (HCC) may enable the discovery novel biomarkers its In this work, metabolomics was used investigate metabolic alterations HCC patients. Plasma samples from patients age-matched healthy controls were investigated using high resolution ultrahigh performance liquid chromatography-mass spectrometry differences analyzed...
Shengxian Decotion (SXT), a well-known Traditional Chinese Medicine (TCM) formula composed of Astragali Radix, Bupleuri Cimicifugae Rhizoma, Anemarrhenae Rhizoma and Platycodonis is clinically considered as an effective against cardiovascular diseases. However, the exact substance SXT in treating chronic heart failure (CHF) still remains unclear. In current study, we investigated benefit doxorubicin (DOX)-induced CHF rats established UHPLC-MS/MS method to simultaneously determine 18 key...
The genus Salvia L. (Lamiaceae) comprises myriad distinct medicinal herbs, with terpenoids as one of their major active chemical groups. Abietane-type diterpenoids (ATDs), such tanshinones and carnosic acids, are specific to exhibit taxonomic diversity among lineages. To elucidate how ATD evolved, we carried out large-scale metabolic phylogenetic analyses 71 species, combined enzyme function, ancestral sequence trait reconstruction, comparative genomics experiments. This integrated approach...
There is limited information about the combined effect of shading time and nitrogen (N) on grain filling quality rice. Therefore, two japonica super rice cultivars, Nanjing 44 Ningjing 3, were used to study N level characteristics panicle as well corresponding yield quality. At a low (150 kg ha−1, 150N), decreased (by 21.07–26.07%) under treatment 20 days before heading (BH) compared with no (NS) treatment. These decreases occurred because shortened length, number primary secondary branches,...
Prostate cancer (PCa) is the second leading cause of death among men and associated with profound metabolic changes.
Mechanical transplanting with carpet seedlings (MC) and mechanical direct seeding (MD) are newly developed planting methods, which increase in popularity planted area each year. Knowing the difference for yield rice quality under different methods is of great importance development high cultivation techniques conditions. Therefore, three kinds japonica including hybrid rice, inbreed soft were adopted as materials. And differences processing, appearance, cooking eating quality, nutrition,...
Metabolomics has been used as a promising strategy to evaluate the efficacy of and potential targets for natural products. Alcoholic liver disease (ALD) result chronic ethanol consumption high morbidity mortality. Geniposide possesses hepatoprotective activity against ALD, but its mechanism action is still not clear. In this study, serum metabolomics based on ultra-performance liquid chromatography-quadrupole time flight-tandem mass spectrometry (UPLC-Q/TOF-MS) combined with ingenuity...
A high-resistant starch (RS) and low-glutelin diet is beneficial for the health of patients with diabetes kidney diseases. Rice an important food crop worldwide. Previous studies have demonstrated that downregulating expression rice branching enzyme IIb (SBEIIb) affected composition structure starch. However, there has been no report about generating loss-of-function mutants SBEIIb using cultivars as recipients. In this study, we adopted a CRISPR/Cas9 system to induce site-specific mutations...