A5074496850- Plant biochemistry and biosynthesis
- Plant tissue culture and regeneration
- Transgenic Plants and Applications
- Photosynthetic Processes and Mechanisms
- Microbial Natural Products and Biosynthesis
- Plant Gene Expression Analysis
- Plant Molecular Biology Research
- Insect Resistance and Genetics
- Plant Stress Responses and Tolerance
- CRISPR and Genetic Engineering
- Plant Reproductive Biology
- Plant Physiology and Cultivation Studies
- Plant-Microbe Interactions and Immunity
- Pharmacological Effects of Natural Compounds
- Fungal Biology and Applications
- Plant Virus Research Studies
- Insect-Plant Interactions and Control
- Plant Pathogenic Bacteria Studies
- Antioxidant Activity and Oxidative Stress
- Plant Pathogens and Fungal Diseases
- Toxin Mechanisms and Immunotoxins
- Malaria Research and Control
- Microbial Metabolic Engineering and Bioproduction
- Research in Cotton Cultivation
- Viral Infectious Diseases and Gene Expression in Insects
Shanghai Jiao Tong University
2016-2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
Sanya University
2025
Guiyang Medical University
2025
Zhejiang University
2025
Biotechnology Research Center
2004-2024
Southwest University
2004-2024
Sichuan Agricultural University
2024
North Carolina Agricultural and Technical State University
2002-2024
Objectives Parasitic Cordyceps fungi, such as sinensis, is a parasitic complex of fungus and caterpillar, which has been used for medicinal purposes centuries particularly in China, Japan other Asian countries. This article gives general idea the latest developments C. sinensis research, with regard to active chemical components, pharmacological effects research development products recent years. Key findings The common names preparations include DongChongXiaCao Chinese, winter worm summer...
Summary Six transcription factors of APETALA2/ethylene‐response factor ( AP 2/ ERF ) family were cloned and analyzed in A rtemisia annua . Real‐time quantitative polymerase chain reaction RT ‐ Q PCR showed that Aa ORA exhibited similar expression patterns to those amorpha‐4,11‐diene synthase gene ADS ), cytochrome P450‐dependent hydroxylase CYP71AV1 double bond reductase 2 DBR2 different tissues a is trichome‐specific factor, which expressed both glandular secretory trichomes GST s)...
The plant Artemisia annua is well known due to the production of artemisinin, a sesquiterpene lactone that widely used in malaria treatment. Phytohormones play important roles secondary metabolism, such as jasmonic acid (JA), which can induce artemisinin biosynthesis A. annua. Nevertheless, JA-inducing mechanism remains poorly understood. expression gene AaMYC2 was rapidly induced by JA and binds G-box-like motifs within promoters CYP71AV1 DBR2, are key structural genes biosynthetic pathway....
Epidemiological studies have shown that regular consumption of fruits and vegetables is associated with reduced risk chronic diseases. It recommended to increase prevent diseases related free radical-induced oxidative stress. Different varieties provide different vitamins, phenolics, flavonoids, minerals, dietary fibers for optimal health benefits. Mung bean sprouts are one the major in human diet. However, profiles phytochemicals effect germination on phytochemical content antioxidant...
Abstract Background Mango is one of the world’s most important tropical fruits. It belongs to family Anacardiaceae, which includes several other economically species, notably cashew, sumac and pistachio from genera. Many species in this produce family-specific urushiols related phenols, can induce contact dermatitis. Results We generate a chromosome-scale genome assembly mango, providing reference for Anacardiaceae family. Our results indicate occurrence recent whole-genome duplication (WGD)...
Glandular trichomes are generally considered biofactories that produce valuable chemicals. Increasing glandular trichome density is a very suitable way to improve the productivity of these metabolites, but little known about regulation formation. Phytohormone jasmonate (JA) promotes initiation in various plants, its mechanism also unknown. By searching transcription factors regulated by JA Artemisia annua, we identified novel homeodomain-leucine zipper factor, HOMEODOMAIN PROTEIN 1 (AaHD1),...
Summary Artemisinin is a type of sesquiterpene lactone well known as an antimalarial drug, and specifically produced in glandular trichomes Artemisia annua . However, the regulatory network for artemisinin biosynthetic pathway remains poorly understood. Exploration trichome‐specific transcription factors would facilitate elucidation mechanism biosynthesis. The WRKY factor GLANDULAR TRICHOME ‐ SPECIFIC 1 ( Aa GSW ) was cloned analysed A. exhibited similar expression patterns to genes AP 2/...
Almost all high-grade gliomas, particularly glioblastoma (GBM), are highly migratory and aggressive. Migrasomes organelles produced by cells capable of mediating intercellular communication. Thus, GBM may produce migrasomes during migration. However, it remains unclear whether can influence migration invasion. In this study, we observed the presence formation in cells. We found that expression levels key migrasome factor, tetraspanin 4 (TSPAN4), correlated positively with pathological grade...
Scopolamine is a pharmaceutically important tropane alkaloid extensively used as an anticholinergic agent. Here, we report the simultaneous introduction and overexpression of genes encoding rate-limiting upstream enzyme putrescine N-methyltransferase (PMT) downstream hyoscyamine 6 β-hydroxylase (H6H) scopolamine biosynthesis in transgenic henbane (Hyoscyamus niger) hairy root cultures. Transgenic lines expressing both pmt h6h produced significantly higher (P < 0.05) levels compared with...
Summary Lignocellulosic biomass was used for thousands of years as animal feed and is now considered a great sugar source biofuels production. It composed mostly secondary cell walls built with polysaccharide polymers that are embedded in lignin to reinforce the wall structure maintain its integrity. Lignin primary material responsible recalcitrance enzymatic hydrolysis. During plant development, deep reductions cause growth defects often correlate loss vessel integrity adversely affects...
Artemisinin is an effective anti-malarial drug isolated from Artemisia annua L. (Chinese wormwood), but the content of artemisinin in A. low. In present study we explored possibility using genetic engineering to increase by suppressing expression SQS (squalene synthase), a key enzyme sterol pathway (a competitive with that biosynthesis) means hairpin-RNA-mediated RNAi (RNA interference) technique. A total 23 independent transgenic plants were obtained through Agrobacterium...
Abstract Vitamin C (L‐ascorbic acid, AsA) has important antioxidant and metabolic functions in both plants animals. Once used, ascorbic acid can be regenerated from its oxidized form a reaction catalyzed by dehydroascorbate reductase (DHAR, EC 1.8.5.1). To analyze the physiological role of DHAR catalyzing reduction DHA to ascorbate environmental stress adaptation, we examined whether increasing level AsA through enhanced recycling would limit deleterious effects oxidative stress. A chimeric...
The effective anti-malarial drug artemisinin (AN) isolated from Artemisia annua is relatively expensive due to the low AN content in plant as only synthesized within glandular trichomes. Therefore, genetic engineering of A. one most promising approaches for improving yield AN. In this work, AaMYB1 transcription factor has been identified and characterized. When overexpressed annua, either exclusively trichomes or whole plant, essential biosynthetic genes are also consequently amount...
Summary Glandular trichomes and cuticles are both specialized structures that cover the epidermis of aerial plant organs. The former commonly regarded as ‘biofactories’ for producing valuable natural products. latter generally considered barriers defending plants against abiotic biotic stresses. However, regulatory network their formation relationship remains largely elusive. Here we identify a homeodomain‐leucine zipper (HD‐ZIP) IV transcription factor, AaHD8, directly promoting expression...
Summary The glandular secretory trichomes ( GST s) on Artemisia annua leaves have the capacity to secrete and store artemisinin, a compound which is most effective treatment for uncomplicated malaria. An strategy improve artemisinin content therefore increase density of s in A. . However, formation mechanism remains poorly understood. To explore mechanisms initiation , we screened myeloblastosis MYB ) transcription factor genes from transcriptome database identified MIXTA factor, Aa 1,...
JA-induced JAZ8 degradation releases and activates the TCP14-ORA complex in enhancing artemisinin biosynthesis Artemisia annua .
In order to improve the production of anticancer dimeric indole alkaloids in Catharanthuse roseus, much research has been dedicated culturing cell lines, hairy roots, and efforts elucidate regulation monoterpenoid alkaloid (MIA) biosynthesis. this study, ORCA3 (Octadecanoid-derivative Responsive Catharanthus AP2-domain) gene alone or integrated with G10H (geraniol 10-hydroxylase) were first introduced into C. roseus plants. Transgenic plants overexpressing (OR lines), co-overexpressing (GO...