A5101501413- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Plant Stress Responses and Tolerance
- Respiratory viral infections research
- RNA modifications and cancer
- Immune Response and Inflammation
- interferon and immune responses
- Photosynthetic Processes and Mechanisms
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Animal Disease Management and Epidemiology
- Respiratory Support and Mechanisms
- RNA Research and Splicing
- Pharmacological Effects of Natural Compounds
- Animal Virus Infections Studies
- Cancer-related gene regulation
- Cytokine Signaling Pathways and Interactions
- Web and Library Services
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Vector-borne infectious diseases
- Pneumonia and Respiratory Infections
- Hippo pathway signaling and YAP/TAZ
- Aquaculture disease management and microbiota
Sichuan Agricultural University
2018-2025
First People’s Hospital of Zunyi
2017-2025
Zunyi Medical University
2023-2025
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2024
Sichuan Center for Disease Control and Prevention
2024
Northeast Forestry University
2011-2023
Jinzhou Medical University
2020
Second Military Medical University
2011-2019
Nanchang University
2015-2019
Hebei Medical University
2018-2019
In recent years, long noncoding RNAs (lncRNAs) have been shown to critical regulatory roles in cancer biology. However, the contributions of lncRNAs hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remain largely unknown. Differentially expressed between HBV-related HCC and paired peritumoral tissues were identified by microarray validated using quantitative real-time polymerase chain reaction. Liver samples from patients with analyzed for levels a specific differentially...
Although numerous long non-coding RNAs (lncRNAs) have been identified in mammals, many of their biological roles remain to be characterized. Early reports suggest that H19 contributes carcinogenesis, including hepatocellular carcinoma (HCC). Examination the Oncomine resource showed most HCC cases express at a level is comparable with liver, tendency toward lower expression. This consistent our previous microarray data and indicates more complicated role needs In this study, expression was...
Artemisinin is an effective anti-malarial drug isolated from Artemisia annua L. (Chinese wormwood), but the content of artemisinin in A. low. In present study we explored possibility using genetic engineering to increase by suppressing expression SQS (squalene synthase), a key enzyme sterol pathway (a competitive with that biosynthesis) means hairpin-RNA-mediated RNAi (RNA interference) technique. A total 23 independent transgenic plants were obtained through Agrobacterium...
In recent years, long noncoding RNAs (lncRNAs) have been investigated as a new class of regulators biological function. A study reported that lncRNAs control cell proliferation in hepatocellular carcinoma (HCC). However, the role liver regeneration and overall mechanisms remain largely unknown. To address this issue, we carried out genome-wide lncRNA microarray analysis during mice after 2/3 partial hepatectomy (PH) at various timepoints. The results revealed differential expression subset...
The Sleeping Beauty (SB) transposon/transposase DNA plasmid system is used to genetically modify cells for long-term transgene expression. We adapted the SB human application and generated T expressing a chimeric antigen receptor (CAR) specific CD19. Electrotransfer of CD19-specific plasmids in peripheral blood mononuclear propagation on CD19+ artificial presenting was numerically expand CD3+ CAR. By day 28 coculture, >90% expanded expressed CAR+ specifically killed target consisted subsets...
Angiogenesis plays a key role in the tumorigenesis and progression of colorectal cancer (CRC). In this study, we investigated effect long noncoding RNA (lncRNA) GAS5 on angiogenesis, invasion, metastasis CRC, involvement Wnt/β-catenin signaling pathway.CRC tissues adjacent normal were collected from 52 patients with CRC. expression was determined vivo vitro by real-time quantitative polymerase chain reaction (RT-qPCR). Then RT-qPCR Western blot used to identify genes pathway. CRC cells...
// Jun Deng 1, * , Wan Lei 1 Xiaojun Xiang Ling Zhang Yu Gong Meijiao Song Yi Wang Ziling Fang Feng Miao Ze Sun Chen Zhengyu Zhan Jianping Xiong Department of Oncology, The First Affiliated Hospital Nanchang University, 330006, PR China first author Correspondence to: Xiong, e-mail: jpxiong@medmail.com Keywords: CUL4A, Hippo, miR-9, miR-137, gastric cancer Received: September 05, 2015 Accepted: December 07, Published: January 28, 2016 ABSTRACT Although Cullin 4A...
The awareness and attention toward lower respiratory tract infections caused by syncytial virus (RSV) are in adults than children. Moreover, the clinical data on severe RSV lacking. This study aimed to augment understanding of infections. was performed 191 adult patients with admitted intensive care unit (ICU) Zunyi Medical University Affiliated Hospital (Zhuhai). sputum specimens were collected for testing, analyzed statistically. findings revealed that RSV-positive group older, had a...
Increasing evidence indicates that microRNA (miR)-506 plays a vital role in tumorigenesis; however, the of miR-506 gastric cancer (GC) is unclear and needs further investigation. In present study, we showed decrease expression associated with tumor size, pathological node metastasis (TNM) stage, lymph 63 GC patient tumors. We found patients lower had poor prognosis than high miR-506. Notably, ectopic was sufficient to inhibit cell proliferation, invasion, epithelial-mesenchymal transition...
Dysregulation of the neddylation pathway is related to various cancers. However, specific role in human hepatocellular carcinoma (HCC) remains largely unclear. In this study, HCC and adjacent noncancerous liver (ANL) tissues was evaluated by immunohistochemistry (IHC), Western blotting, qRT-PCR (quantitative real-time polymerase chain reaction). The results showed that entire pathway, including NEDD8 (the IHC staining represents global-protein neddylation), E1 NEDD8-activating enzymes (NAE1...
Abstract The heart experiences damage and undergoes changes in energy metabolism under condition of hypoxia. Ferroptosis is a novel form cell death characterized by the accumulation reactive oxygen species (ROS) excessive lipid oxidation. However, relationship between cardiac ferroptosis at high altitudes remains unexplored. This study investigates effects high-altitude hypoxia on function explores underlying mechanisms. results demonstrate that exposure to induces structural functional...
Deubiquitination has emerged as an important mechanism of regulating DNA repair pathways. We recently reported that USP24 is a novel p53 deubiquitinase stabilizes upon damage. upregulated by damaging agents and plays role in maintaining genome stability.
Respiratory syncytial virus (RSV) infection in adults remains less recognized and understood, both socially clinically, compared to influenza infection. This retrospective study aims delineate compare the clinical manifestations of adult RSV infections lower respiratory tract, thereby enhancing awareness tract providing strategic insights for its prevention treatment.Clinical data from January 2019 December 2020 were analyzed 74 patients with 129 A/B who admitted or intensive care units. All...
The objective of the study is to explore role respiratory syncytial virus Toll-like receptor 3 (TLR3)-mediated immune response in pathogenesis acute exacerbations chronic obstructive pulmonary disease (AECOPD). A total 20 AECOPD patients and 10 normal volunteers were studied. TLR3 was detected by RT-PCR, (RSV) nested RT-PCR. Then, A549 cells infected RSV at different time points viral titers. mRNA protein interferon regulatory factor (IRF3) western blot, IRF3 localization immunofluorescence....
Duck hepatitis A virus type 1 (DHAV-1) is one of the most common and lethal pathogens in young ducklings. Live-attenuated DHAV vaccine (CH60 strain) developed by passaging chicken embryos provided effective immune protection for However, accurate mechanism such adaption not fully revealed. Here, we utilize RNA-sequencing to perform global transcriptional analysis DHAV-1-innoculated embryonated livers along with histopathological ultrastructural analysis. This study revealed that infection...
Abstract Baicalin has been reported to protect mice against Salmonella typhimurium ( S. ) infection, while its molecular mechanisms are unclear. In this study, multiplicity of infection (MOI) and observation time were measured. Cell viability LDH levels examined in RAW264.7 cells H9 cells. stimulated with S the presence or absence Baicalin, pro‐inflammatory cytokines detected by enzyme‐linked immunosorbent assay (ELISA). The changes reactive oxygen species (ROS) production determined...