A5035312767- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Microbial infections and disease research
- Antibiotic Resistance in Bacteria
- Toxoplasma gondii Research Studies
- Virus-based gene therapy research
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- Viral Infections and Vectors
- Viral-associated cancers and disorders
- Pharmaceutical and Antibiotic Environmental Impacts
- Toxin Mechanisms and Immunotoxins
- Vector-borne infectious diseases
- Microbial Fuel Cells and Bioremediation
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Hepatitis Viruses Studies and Epidemiology
Sichuan Agricultural University
2016-2025
Sichuan Center for Disease Control and Prevention
2023-2025
Ministry of Education of the People's Republic of China
2023-2025
Sanya University
2025
Hainan University
2025
Science and Technology Department of Sichuan Province
2024
Erasmus MC
2018-2022
China Rural Technology Development Center
2016
Goose astrovirus (GAstV) is a newly identified viral pathogen threatening waterfowl, exhibiting high prevalence across various regions in China. Notably, the Guanghan District of Deyang City, situated Sichuan Province, has faced outbreak GAstV, resulting significant mortality among goslings due to induction gout-like symptoms. In our research, we successfully isolated GAstV strain known as SCG3. This exhibits efficient replication capabilities, proving virulent and goose embryos. Our study...
There are rising concerns about microbes harboring antibiotic resistance genes (ARGs) and virulence-associated (VAGs) in humans food-producing animals. Moreover, ARGs considered as emerging environmental pollutants, posing probable life-threatening complications Commensal Escherichia coli (E. coli) strain can carry a large number of VAGs, which may become opportunistic pathogen. The objective this study was to determine the prevalence possible association VAGs E. isolates from clinically...
Duck hepatitis A virus type 1 (DHAV-1) is an acute, highly lethal infectious agent that infects ducklings and causes up to 95% mortality in week of age, posing a significant economic threat the duck farming industry. Previous studies have found proteolytic enzyme 3 C encoded by DHAV-1 can inhibit IRF7 protein from blocking upstream signaling pathway I interferon promote viral replication. However, there are still few on mechanism immune evasion. Here, we demonstrate 3CD interact with reduce...
DPV is a highly lethal alphaherpesvirus that causes duck plague in birds of the order Anseriformes. The virus has caused huge economic losses to poultry industry due high morbidity and mortality cost vaccination.
In bacteria, manganese homeostasis is controlled by import, regulation, and efflux. Here, we identified 2 Mn exporters, MetA MetB (manganese efflux transporters A B), in Riemerella anatipestifer CH-1, encoding a putative cation diffusion facilitator (CDF) protein resistance-nodulation-division (RND) pump, respectively. Compared with the wild type (WT), ΔmetA, ΔmetB, ΔmetAΔmetB exhibited sensitivity to manganese, since they accumulated more intracellular Mn2+ than WT under excess conditions,...
With the increasing number of ducks being raised and consumed, it is crucial to monitor presence multidrug resistant (MDR) bacteria in duck farming. Waterfowl, such as ducks, can contribute rapid dissemination antibiotic resistance genes (ARGs). The objective this study was investigate antimicrobial (AMR), ARGs, mobile genetic elements (MGEs), IS26, tbrC, ISEcp1 Escherichia coli(E. coli) isolated from intestinal contents diseased between 2021 2022 Sichuan, Chongqing Anhui, China. AMR...
Abstract Background The disease caused by Riemerella anatipestifer ( R. , RA) results in large economic losses to the global duck industry every year. Serovar-related genomic variation, such as O-antigen and capsular polysaccharide (CPS) gene clusters, has been widely used for serotyping many gram-negative bacteria. RA classified into at least 21 serovars based on slide agglutination, but molecular basis of is unknown. In this study, we performed a pan-genome-wide association study...
Avian reovirus (ARV), a double-stranded RNA virus, frequently induces immunosuppression in poultry, leading to symptoms such as irregular bleeding and spleen necrosis infected ducks. Since 2017, the morbidity mortality rates associated with ARV infection poultry have been on rise, progressively emerging significant viral disease impacting duck farming industry China. In our study, we collected embryo fibroblasts 18 h post-infection conducted transcriptome sequencing analysis. The analysis...
Areca catechu, as a traditional Chinese medicine, contains high concentration of therapeutic compounds. However, the biosynthesis these compounds is largely unexplored. We present haplotype-resolved genome assembly and annotation for A. with chromosome-level sizes 2.45 Gb (Ac. Hap1) 2.49 Hap2). A comparative analysis haplotypes revealed significant divergence, including multiple Mb-level large inversions. Furthermore, catechu shared two whole duplications other palm plants its size had...
Because of their better immunogenicity and the improved protection they afford, live attenuated vaccines derived from serial passaging in an abnormal host are widely used to protect humans or animals certain pathogens. Here, we a virulent chicken embryo-attenuated duck hepatitis A virus genotype 1 compare different regulated immune responses induced by viruses with differing virulence. In this study, strains had lower protein expression levels than as identified immunohistochemistry. This...
Duck circovirus genotype 2 (DuCV2) belongs to the genus Circovirus, family Circoviridae. It can generally cause lymphocyte atrophy and necrosis in ducks, which leads immunosuppression. The function of DuCV2 open reading frame 3 (ORF3) protein viral pathogenesis host cells remains unclear. Therefore, a series studies based on ORF3 isolate DuCV GH01 strain (belonging DuCV2) were carried out duck embryo fibroblasts (DEFs) this study. results showed that could induce nuclear shrinkage...