A5067055286- Systemic Sclerosis and Related Diseases
- Medicinal Plant Pharmacodynamics Research
- Dermatologic Treatments and Research
- Mast cells and histamine
- Cancer-related molecular mechanisms research
- Inflammatory Myopathies and Dermatomyositis
- Phytochemical compounds biological activities
- Eosinophilic Disorders and Syndromes
- Systemic Lupus Erythematosus Research
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- Rheumatoid Arthritis Research and Therapies
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
Hangzhou Hospital of Traditional Chinese Medicine
2023
Nanjing University
2023
Nanjing University of Chinese Medicine
2019
Jiangsu Province Hospital
2019
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2018
Abstract Objectives Circular RNA, a type of RNA formed by covalently closed loop, possesses sophisticated abilities gene regulation in tumorigenesis and metastasis. However, the role circRNAs on lung adenocarcinoma (LUAD) remains largely unknown. Materials methods The cMras was examined both vitro vivo. expression LUAD tissues determined quantitative real‐time PCR (qRT‐PCR). Downstream targets were predicted bioinformatics tools confirmed immunoprecipitation assay luciferase assay. qRT‐PCR...
Abstract Background Rheumatoid arthritis (RA) is a kind of systemic autoimmune disease, and the joint inflammation cartilage destruction are major features. Some traditional Chinese medicine have been discovered to exhibit regulatory roles in treatment RA. Forsythiaside A (FA) as an active ingredient isolated from forsythia suspensa has participate into regulation some diseases through improving inflammation. However, effects FA on progression RA keep indistinct. Methods IL‐1β (10 ng/mL)...
Systemic sclerosis (SSc) is a rare chronic autoimmune disorder, mainly characterized by skin sclerosis. In this study, Bufei Qingyu Granules (BQG), Chinese herbal formula, was used to treat SSc. To better understand the effects and molecular mechanisms of BQG, we successfully established Bleomycin- (BLM-) induced SSc mouse model, mice were treated BQG. Meanwhile, transcriptomic bioinformatics analyses conducted on those samples. As result, visually showed that BQG ameliorated overall health...
Fibrosis is the characteristic hallmark of systemic sclerosis (SSc). Although specific mechanism has been unknown, role macrophages in development this complex disease through various ways cannot be negligible. Findings during past 5 years have contributed to more understanding relationship between and SSc. This review mainly about progress research on We discuss whether or not skew toward M1-like phenotype from profibrotic M2-like phenotype. Some biomarkers are also listed. In addition, we...