A5100754263- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Cancer, Lipids, and Metabolism
- Milk Quality and Mastitis in Dairy Cows
- Immune Response and Inflammation
- RNA Research and Splicing
- Peroxisome Proliferator-Activated Receptors
- Infant Nutrition and Health
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ubiquitin and proteasome pathways
- Gene expression and cancer classification
- Immune Cell Function and Interaction
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Polyoxometalates: Synthesis and Applications
- Supercapacitor Materials and Fabrication
- Animal Genetics and Reproduction
Northeast Agricultural University
2012-2024
Beijing Forestry University
2024
Gansu University of Traditional Chinese Medicine
2023
Anhui University of Science and Technology
2023
Harbin Normal University
2022-2023
Nanjing Medical University
2012-2022
Shanghai Veterinary Research Institute
2016-2022
Chinese Academy of Agricultural Sciences
2014-2022
Tongji University
2022
Lanzhou Institute of Husbandry and Pharmaceutical Sciences
2022
Abstract Effective recognition of viral infection and subsequent triggering antiviral innate immune responses are essential for the host defense, which is tightly regulated by multiple regulators, including microRNAs. Our previous study showed that a panel microRNAs, miR-155, was markedly upregulated in macrophages upon vesicular stomatitis virus infection; however, biological function miR-155 during remains unknown. In this paper, we show RNA induces expression via TLR/MyD88-independent but...
In our in-depth analysis carried out by the Illumina Solexa massive parallel signature sequencing, microRNA-99a (miR-99a) was found to be sixth abundant microRNA in miRNome of normal human liver but markedly down-regulated hepatocellular carcinoma (HCC). Compelling evidence has suggested important roles microRNAs HCC development. However, biological function miR-99a deregulation remains unknown. this study, we that remarkably decreased tissues and cell lines. Importantly, lower expression...
Abstract Recent studies of the individual functionalities long non‐coding RNAs (lncRNAs) in development and progression cancer have suggested that HOX transcript antisense RNA (HOTAIR) is capable reprogramming chromatin organization promoting cell metastasis. In order to ascertain expression pattern lncRNA HOTAIR assess its biological role esophageal squamous carcinoma (ESCC), ESCC tissues adjacent noncancerous were collected from 78 patients measured by real‐time reverse...
Multiple signaling pathways are involved in the tight regulation of Toll-like receptor (TLR) signaling, which is important for tailoring inflammatory response to pathogens macrophages. It widely accepted that TLR can activate Notch pathway; however, whether full activation feedback modulate pathway so as control inflammation remains unclear. Here, we demonstrated stimulation with ligands up-regulated Notch1 and Notch2 expression The target genes including Hes1 Hes5 was also induced...
Sterol regulatory element-binding proteins (SREBPs) belong to a family of nuclear transcription factors. The question which is the most important positive regulator in milk fat synthesis dairy cow mammary epithelial cells (DCMECs) between SREBPs or other factors, such as peroxisome proliferator-activated receptor γ (PPARγ), remains controversial one. Recent studies have found that mTORC1 (the mammalian target rapamycin C1) regulates SREBP1 promote synthesis. Thus far, however, interaction...
LncRNA SPRY4-IT1 has been shown to promote the progression of melanoma. However, role lncRNA in human esophageal squamous cell carcinoma (ESCC) remains unclear. The purpose this study is investigate clinical significance and biological functions ESCC. expression levels SPRY4-IT 92 ESCC patients 8 lines were evaluated by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). prognostic was using Kaplan–Meier Cox regression analyses. Small interfering RNA (siRNA) used suppress...
MicroRNAs (miRNAs) are small, endogenous, non‑coding RNA molecules that function as post‑transcriptional regulators of gene expression by imperfect base‑pairing with the 3'‑untranslated regions their target mRNAs. Altered numerous miRNAs has been shown to be extensively involved in pathogenesis various diseases and cancers. Additionally, specific nervous system indicated critical for occurrence development neurological diseases. Increasing evidence particular proteins significant disease...
Mammary gland development is controlled by several genes. Although miRNAs have been implicated in mammary function, the mechanism which miR-486 regulates and lactation remains unclear. We investigated expression cow using qRT-PCR ISH show that was higher during high-quality period. found targets phosphoinositide signaling directly downregulating PTEN gene altering of downstream genes are important for function gland, such as AKT, mTOR. analyzed effect β-casein, lactose triglyceride secretion...
Lysine methylation is an important posttranslational modification, implicated in various biological pathological conditions. The transcription factor interferon regulatory 3 (IRF3) essential for antiviral innate immunity, yet the mechanism control of IRF3 activation remains unclear. In this paper, we discovered monomethylation at K366 critical activity immunity. By mass spectrometry analysis IRF3-associated proteins, identified nuclear receptor–binding SET domain (NSD3) as lysine...
Colorectal carcinoma (CRC) is one of the most common types digestive cancer. It has been reported that ectopic expression microRNAs (miRs) plays a critical role in occurrence and progression CRC. In addition, it also suggested miR‑151a‑5p may serve as useful biomarker for early detection treatment different cancer particularly However, specific effects underlying mechanisms CRC remain elusive. The results current study demonstrated was upregulated cell lines clinical tissues derived from...
The spatial-temporal distribution and variability of soil moisture (SM) constitutes a critical foundation for coordinating agricultural productivity, ecological preservation, mountain flood disaster mitigation. Based on observed SM data from 27 automated monitoring stations established by the Aerospace Information Research Institute during 2022-2024 across different climatic zones in China, temporal change patterns, spatial heterogeneity characteristics, dominant meteorological influencing...
Objective: A20 is a TNF-inducible primary response gene, which has been found to have antiapoptotic function in several cancer cells. This study investigates expression human glioma tissues and four cell lines, its effect on tumorigenesis of cells mouse tumor model. Methods: Human tissue samples were subject reverse transcription-PCR (RT-PCR), western blotting immunohistochemistry. Glioma was tested by flow cytometry. A xenograft model mice utilized examine the knock-down specific siRNAs...
MicroRNAs (miRs) are short, non-coding RNAs with post-transcriptional regulatory functions. Previous studies have demonstrated that miR-34c is involved in diverse biological processes, including carcinogenesis. The aim of the present study was to investigate role and its target genes hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Expression levels predicted were measured. validated by a luciferase assay. effects restoration evaluated detection HBV antigens, cell...
Chemotherapy resistance, the molecular mechanism of which is complex and has not been fully understood, poses a major challenge in treatment patients with non‑small cell lung cancer (NSCLC). The dysregulation microRNAs (miRs) reported to serve pivotal role development drug resistance. In present study, reverse transcription‑quantitative polymerase chain reaction analysis revealed significant increase miR‑328 decrease phosphatase tensin homolog (PTEN) mRNA expression levels within tumor...