A5032806661- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Infection Control and Ventilation
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Mycobacterium research and diagnosis
- Infection Control in Healthcare
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- COVID-19 and healthcare impacts
- Animal Virus Infections Studies
- Tuberculosis Research and Epidemiology
- COVID-19 and Mental Health
- Clostridium difficile and Clostridium perfringens research
- Infectious Diseases and Tuberculosis
- Bacterial biofilms and quorum sensing
- Streptococcal Infections and Treatments
- Trauma and Emergency Care Studies
- Herpesvirus Infections and Treatments
Queen Mary Hospital
2016-2025
University of Hong Kong
2016-2025
University of Southern California
2016-2025
Los Angeles Medical Center
2015-2025
Southmead Hospital
2024-2025
University of Bristol
2024-2025
Kaiser Permanente Oakland Medical Center
2024
Kaiser Permanente South Sacramento Medical Center
2023-2024
Chinese University of Hong Kong
2003-2024
Brown University
2024
An ongoing outbreak of pneumonia associated with a novel coronavirus was reported in Wuhan city, Hubei province, China. Affected patients were geographically linked local wet market as potential source. No data on person-to-person or nosocomial transmission have been published to date.
An outbreak of severe acute respiratory syndrome (SARS) has been reported in Hong Kong. We investigated the viral cause and clinical presentation among 50 patients.We analysed case notes microbiological findings for patients with SARS, representing more than five separate epidemiologically linked transmission clusters. defined risk factors associated disease causal agents by chest radiography laboratory testing nasopharyngeal aspirates sera samples. compared those submitted investigation...
We investigated the temporal progression of clinical, radiological, and virological changes in a community outbreak severe acute respiratory syndrome (SARS).We followed up 75 patients for 3 weeks managed with standard treatment protocol ribavirin corticosteroids, assessed pattern clinical disease, viral load, risk factors poor outcome, usefulness diagnostic methods.Fever pneumonia initially improved but 64 (85%) developed recurrent fever after mean 8.9 (SD 3.1) days, 55 (73%) had watery...
Abstract The 2019 novel coronavirus (2019-nCoV) was detected in the self-collected saliva of 91.7% (11/12) patients. Serial viral load monitoring generally showed a declining trend. Live virus by culture. Saliva is promising noninvasive specimen for diagnosis, monitoring, and infection control patients with 2019-nCoV infection.
Abstract Background There are many pharmacologic therapies that being used or considered for treatment of coronavirus disease 2019 (COVID-19). is a need frequently updated practice guidelines on their use, based critical evaluation rapidly emerging literature. The objective was to develop evidence-based rapid intended support patients, clinicians, and other healthcare professionals in decisions about management patients with COVID-19. Methods Infectious Diseases Society America (IDSA) formed...
On 31 December 2019, the World Health Organization was informed of a cluster cases pneumonia unknown etiology in Wuhan, China. Subsequent investigations identified novel coronavirus, now named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from affected patients. Highly sensitive and specific laboratory diagnostics are important for controlling rapidly evolving SARS-CoV-2-associated disease 2019 (COVID-19) epidemic. In this study, we developed compared performance three...
BackgroundFace mask usage by the healthy population in community to reduce risk of transmission respiratory viruses remains controversial. We assessed effect community-wide control coronavirus disease 2019 (COVID-19) Hong Kong Special Administrative Region (HKSAR).MethodsPatients presenting with symptoms at outpatient clinics or hospital wards were screened for COVID-19 per protocol. Epidemiological analysis was performed confirmed cases, especially persons acquiring during mask-off and...
Waning immunity occurs in patients who have recovered from Coronavirus Disease 2019 (COVID-19). However, it remains unclear whether true re-infection occurs.Whole genome sequencing was performed directly on respiratory specimens collected during 2 episodes of COVID-19 a patient. Comparative analysis conducted to differentiate persistent viral shedding. Laboratory results, including RT-PCR Ct values and serum Severe Acute Respiratory Syndrome (SARS-CoV-2) IgG, were analyzed.The second episode...
Abstract Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is believed to be mostly transmitted medium- large-sized droplets, although airborne transmission may possible in healthcare settings involving aerosol-generating procedures. Exposure droplets can theoretically reduced surgical mask usage. However, there a lack of experimental evidence supporting usage for prevention COVID-19. Methods We used well-established golden...
Abstract Objective: To describe the infection control preparedness measures undertaken for coronavirus disease (COVID-19) due to SARS-CoV-2 (previously known as 2019 novel coronavirus) in first 42 days after announcement of a cluster pneumonia China, on December 31, (day 1) Hong Kong. Methods: A bundled approach active and enhanced laboratory surveillance, early airborne isolation, rapid molecular diagnostic testing, contact tracing healthcare workers (HCWs) with unprotected exposure...
ABSTRACT We have recently described the discovery of a novel coronavirus, coronavirus HKU1 (CoV-HKU1), associated with community-acquired pneumonia. However, clinical spectrum disease and epidemiology CoV-HKU1 infections in relation to other respiratory viruses are unknown. In this 12-month prospective study, 4,181 nasopharyngeal aspirates from patients acute tract were subjected reverse transcription-PCRs specific for human coronaviruses NL63 (HCoV-NL63), OC43 (HCoV-OC43), 229E (HCoV-229E)....
Background. Infections caused by the pandemic H1N1 2009 influenza virus range from mild upper respiratory tract syndromes to fatal diseases. However, studies comparing virological and immunological profile of different clinical severity are lacking. Methods. We conducted a retrospective cohort study 74 patients with infection, including 23 who either developed acute distress syndrome (ARDS) or died (ARDS-death group), 14 desaturation requiring oxygen supplementation survived without ARDS...
Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant, designated as a variant of concern by the World Health Organization, carries numerous spike mutations that are known to evade neutralizing antibodies elicited disease 2019 (COVID-19) vaccines. A deeper understanding susceptibility vaccine-induced is urgently needed for risk assessment. Methods Omicron strains HKU691 and HKU344-R346K were isolated from patients using TMPRSS2-overexpressing...
BackgroundIn late 2019, a novel human coronavirus – severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in Wuhan, China. This virus has caused global pandemic involving more than 200 countries. SARS-CoV-2 is highly adapted to humans and readily transmits from person-to-person.AimTo investigate the infectivity of under various environmental pH conditions. The efficacies laboratory inactivation methods home disinfectants against were investigated.MethodsThe residual dried form...
Abstract All hepatitis E virus (HEV) variants reported to infect humans belong the species Orthohepevirus A (HEV-A). The zoonotic potential of C (HEV-C), which circulates in rats and is highly divergent from HEV-A, unknown. We report a liver transplant recipient with caused by HEV-C infection. detected RNA multiple clinical samples antigen liver. complete genome isolate had 93.7% nt similarity an strain Vietnam. patient preexisting HEV antibodies, were not protective against Ribavirin was...
The emerging novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) was recently isolated from patients with severe pneumonia and renal failure associated an unexplained high crude fatality rate of 56%. We performed a cell line susceptibility study 28 lines. HCoV-EMC found to infect the respiratory tract (polarized airway epithelium Calu-3, embryonic fibroblast HFL, lung adenocarcinoma A549), kidney (embryonic HEK), intestinal (colorectal Caco-2), liver cells (hepatocellular carcinoma Huh-7),...