A5010609515- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver physiology and pathology
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Kawasaki Disease and Coronary Complications
- Hepatocellular Carcinoma Treatment and Prognosis
- GDF15 and Related Biomarkers
- Acute Ischemic Stroke Management
- Autophagy in Disease and Therapy
- Systemic Lupus Erythematosus Research
- Hepatitis Viruses Studies and Epidemiology
- Coronary Artery Anomalies
- Pancreatitis Pathology and Treatment
- Organ Transplantation Techniques and Outcomes
- Nutrition and Health in Aging
- Neurological Disease Mechanisms and Treatments
- Lipoproteins and Cardiovascular Health
- Innovative Microfluidic and Catalytic Techniques Innovation
- Digestive system and related health
- Cardiac Structural Anomalies and Repair
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
National Clinical Research Center for Digestive Diseases
2017-2025
Capital Medical University
2016-2025
Beijing Friendship Hospital
2016-2025
Anhui Medical University
2025
China Academy of Chinese Medical Sciences
2025
Air Force Medical University
2025
Peking University
2024
Sun Yat-sen University Cancer Center
2024
Wuxi No.2 People's Hospital
2024
Renji Hospital
2012-2024
To facilitate the achieving of goal "eliminating viral hepatitis as a major public health threat by 2030" set World Health Organization, Chinese Society Hepatology together with Infectious Diseases (both are branches Medical Association) organized panel experts and updated guidelines for prevention treatment chronic B in China (version 2022). With support available evidence, this revision focuses on active prevention, large scale testing, expansion therapeutic indication aim reducing related...
Liver fibrosis is the net result of dynamic changes between fibrogenesis and fibrolysis. Evidence has shown that antiviral therapy can reverse liver or even early cirrhosis caused by hepatitis B virus. However, current evaluation systems mainly focus on severity of, but not in, fibrosis. Here, we propose a new classification to evaluate in quality fibrosis, namely: predominantly progressive (thick/broad/loose/pale septa with inflammation); predominately regressive...
Background & AimsProgression of liver fibrosis still occurs in some patients with chronic hepatitis B virus (HBV) infection despite antiviral therapy. We aimed to identify risk factors for progression who received therapy.MethodsWe conducted a longitudinal study HBV and biopsies collected before after 78 weeks anti-HBV Fibrosis was defined as Ishak stage increase ≥ 1 or predominantly progressive classified by P-I-R system (Beijing Classification). Levels DNA RNA blood samples were measured...
Ischemic stroke is the leading cause of disabilities worldwide. MicroRNA-377 (miR-377) plays important roles in ischemic injury. The present study focused on mechanisms miR-377 protecting brain injury rats. Cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) Primary rat microglial cells and microvascular endothelial (BMECs) were exposed to oxygen-glucose deprivation (OGD). concentrations cytokines (TNF-α, IL-1β, IL-6, IFN-γ, TGF-β, MMP2, COX2, iNOS) culture medium...
Background . Evidences are accumulating that age and gender have great impact on the distribution of stroke risk factors. Such data lacking in Chinese population. Methods 1027 patients with first-ever ischemic (IS) were recruited divided into young adult (<50 years), middle-aged (50∼80 very old (>80 years) groups according to onset ages. Vascular factors collected compared among groups. Results Female globally older than male at having higher prevalence diabetes mellitus (DM), heart...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) affects cholesterol homeostasis by targeting hepatic LDL receptor (LDLR) for lysosomal degradation. Clinically, PCSK9 inhibitors effectively reduce LDL-cholesterol (LDL-C) levels and the incidence of cardiovascular events. Because microRNAs (miRs) are integral regulators homeostasis, we investigated involvement miR-483 in regulating LDL-C metabolism. Using silico analysis, predicted that miR-483-5p targets 3'-UTR mRNA. In HepG2 cells,...
This study aimed to investigate whether ischemic postconditioning (IpostC) alleviates cerebral ischemia/reperfusion (I/R) injury involved in autophagy. Adult Sprague-Dawley rats were divided into five groups: sham (sham surgery), I/R (middle artery occlusion [MCAO] for 100 min, then reperfusion), IpostC (MCAO reperfusion 10 MCAO IpostC+3MA (3-methyladenine, an autophagy inhibitor, administered 30 min before first and IpostC+Veh (vehicle control group). Infarct volume was measured using...
Current widely used semiquantitative histological assessment methods are insensitive to identify subtle changes of liver fibrosis. Therefore, precisely assess therapeutic efficacy on chronic hepatitis B (CHB), we explored the utility qFibrosis (a fully-quantitative morphometric method employing second harmonic generation/two photon excitation fluorescence) in fibrosis evaluation. Fibrosis were evaluated by Ishak scoring and CHB patients with paired biopsies before after 78 weeks' antiviral...
Abstract It has been reported that liver fibrosis could be reversed after eliminating injuries. This article systematically summarizes the evidence of regression based on histology, stiffness, and serum biomarkers, discusses several clinically relevant challenges. Evidence from biopsy regarded as gold standard in assessment regression. Semi-quantitative staging grading systems are traditionally routinely used to define Recently, predominantly regressive, indeterminate, progressive score was...
Elastin is an amorphous protein highly resistant to elastase degradation and believed be the most stable component among extracellular matrix (ECM) members. Thus excessive deposition of elastin in advanced liver fibrosis may contribute declining reversibility disease. Our previous study has found that crosslinking inhibition can effectively arrest progression. To further understand roles involved fibrosis, we systematically investigated expression, accumulation, based on dynamic...
Background: Kawasaki disease (KD) is characterized by a disorder of immune response, and its etiology remains unknown. Monocyte an important member the body’s innate system; however role in KD still elusive due to ambiguous heterogeneity complex functions. We aim comprehensively delineate monocyte healthy infants reveal underlying mechanism for KD. Methods: Peripheral monocytes were enriched from peripheral blood samples two infants. scRNA-seq was performed acquire transcriptomic atlas...
This paper constructs an enterprise green development performance system by integrating concept and measurement. Based on the panel data of 458 industrial listed enterprises in China from 2011 to 2018, this simulates index using functional analysis method entropy weight method. There are four main conclusions. First, change is U-shaped, which shows upward trend overall. Within a range [0.006–0.05], minimum value 0.006, considering strength future policies there no maximum value. The higher...
Thrombospondin-2 (THBS2) expression is associated with liver fibrosis regardless of etiology. However, the role THBS2 in pathogenesis has yet to be elucidated.
It is unclear whether liver stiffness measurement (LSM) dynamic changes after anti-HBV treatment could predict the risk of liver-related events (LREs), particularly in patients with HBV-related compensated cirrhosis.Treatment-naïve cirrhosis were enrolled. All under entecavir-based antiviral therapy, and followed up every 26 weeks for 2 years. The association between LSM LREs was analysed by Cox proportional hazard model Harrell C-index analysis.A total 438 included study. At follow-up 104...
Purpose: The clinical utility of cell-free DNA (cfDNA) to assess EGFR mutations is increasing. However, there are limited studies determining their validity and utility. value cfDNA assays in cancer management remains controversial. Methods: In this study, we first evaluated the analytical performance ddPCR Lung Assay. We next analyzed concordance results with tissue amplification refractory mutation system PCR (ARMS-PCR) plasma next-generation sequencing (NGS) genotyping. Finally, assessed...
Background & Aims: Excessive deposition and crosslinking of extracellular matrix increases liver density stiffness, promotes fibrogenesis, resistance to fibrinolysis. An emerging therapeutic opportunity in fibrosis is target the composition or block pathogenic communication with surrounding cells. However, type extent changes triggering depend on underlying etiology. Our aim was unveil matrisome genes not dependent etiology, which are clinically relevant fibrosis. Approach Results: We...