A5100779307- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Cancer, Lipids, and Metabolism
- Advanced Glycation End Products research
- Ferroptosis and cancer prognosis
- Endoplasmic Reticulum Stress and Disease
- Renal cell carcinoma treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- SARS-CoV-2 and COVID-19 Research
- Bone and Dental Protein Studies
- Allergic Rhinitis and Sensitization
- Genital Health and Disease
- Liver physiology and pathology
- Plant Stress Responses and Tolerance
- Reconstructive Surgery and Microvascular Techniques
- Eicosanoids and Hypertension Pharmacology
- Cancer Immunotherapy and Biomarkers
- Birth, Development, and Health
- Economic and Financial Impacts of Cancer
- Diet, Metabolism, and Disease
- Antibiotics Pharmacokinetics and Efficacy
- Asthma and respiratory diseases
- Hepatitis B Virus Studies
- Food composition and properties
- Antibiotic Resistance in Bacteria
Sun Yat-sen University
2010-2025
Sun Yat-sen University Cancer Center
2010-2025
University of Illinois Chicago
2019-2025
Anhui University of Traditional Chinese Medicine
2022-2025
Shanghai CASB Biotechnology (China)
2025
Heilongjiang Academy of Sciences
2014-2024
Qilu Hospital of Shandong University
2013-2024
Northwest A&F University
2023-2024
National Center for Women and Children’s Health, China CDC
2011-2024
National University of Defense Technology
2024
Quinoxalin-2(1H)-one based design and synthesis produced several series of aldose reductase (ALR2) inhibitor candidates. In particular, phenolic structure was installed in the compounds for combination antioxidant activity strengthening ability to fight against diabetic complications. Most 6 showed potent selective effects on ALR2 inhibition with IC50 values range 0.032-0.468 μM, 2-(3-(2,4-dihydroxyphenyl)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid (6e) most active. More significantly, 8...
Background & AimsNonalcoholic steatohepatitis (NASH) is characterized by steatosis, lobular inflammation, hepatocyte ballooning degeneration, and fibrosis, all of which increase the risk progression to end-stage liver disease. Osteopontin (OPN, SPP1) plays an important role in macrophage (MF) biology, but whether MF-derived OPN affects NASH unknown.MethodsWe analyzed publicly available transcriptomic datasets from patients with NASH, used mice conditional overexpression or ablation Spp1...
We report a human case of viral encephalitis caused by pseudorabies virus (PRV) in China. A 43-year-old man with no previous medical history presented high-grade fever, headache and tonic-clonic seizures as well coma. Plain computer tomography (CT) brain imaging showed hypo-density the bilateral basal ganglia, occipital lobe, limbic left thalamic. Next-generation sequencing (NGS) confirmed presence PRV cerebral spinal fluid (CSF). Regular polymerase chain reaction (PCR) was applied to...
Background and Aims: HCC, the third leading cause of cancer-related death, arises in context liver fibrosis. Although HCC is generally poorly fibrogenic, some tumors harbor focal intratumor extracellular matrix (ECM) deposits called “fibrous nests.” To date, molecular composition clinical relevance these ECM have not been fully defined. Approach Results: We performed quantitative matrisome analysis by tandem mass tags spectrometry 20 human cancer specific (HCCs) with high or low-grade...
Angiotensin-converting enzyme 2 (ACE2) is a major cell entry receptor for severe acute respiratory syndrome coronavirus (SARS-CoV-2). The induction of ACE2 expression may serve as strategy by SARS-CoV-2 to facilitate its propagation. However, the regulatory mechanisms after viral infection remain largely unknown. Using 45 different luciferase reporters, transcription factors SP1 and HNF4α were found positively negatively regulate expression, respectively, at transcriptional level in human...
Background & AimsThe gut-liver axis plays a key role in the pathogenesis of alcohol-associated liver disease (ALD). We demonstrated that Opn-/- develop worse ALD than wild-type (WT) mice; however, intestinal osteopontin (OPN) remains unknown. hypothesized overexpression OPN epithelial cells (IECs) could ameliorate by preserving gut microbiome and barrier function.MethodsOpnKI IEC, OpnΔIEC, WT mice were fed control or ethanol Lieber-DeCarli diet for 6 weeks.ResultsOpnKI IEC but not OpnΔIEC...
Background & Aims: Excessive deposition and crosslinking of extracellular matrix increases liver density stiffness, promotes fibrogenesis, resistance to fibrinolysis. An emerging therapeutic opportunity in fibrosis is target the composition or block pathogenic communication with surrounding cells. However, type extent changes triggering depend on underlying etiology. Our aim was unveil matrisome genes not dependent etiology, which are clinically relevant fibrosis. Approach Results: We...
530 Background: Partial nephrectomy is the standard treatment for early-stage renal cell carcinoma; however, in some patients, although tumor early-stage, surgical difficulty may preclude its implementation. This study aims to evaluate efficacy and safety of Cadonilimab combined with Lenvatinib neoadjuvant therapy carcinoma indications partial but high risk. Methods: a single-center, single-arm Phase II clinical trial. Eligible patients included those biopsy-confirmed clear who had were at...
The serum ceruloplasmin assay is the most commonly used test for diagnosing Wilson's disease (WD). Despite utility of non-invasive tests WD, no such have been developed. Therefore, we aimed to identify a safe and determine factors associated with salivary ceruloplasmin. sample comprised 167 participants: 130 patients WD (experimental group) 37 individuals without (control group). Salivary ceruloplasmin's diagnostic performance was assessed using receiver operating characteristic curve...
Microfibrillar-associated protein 2 (MFAP-2) is a crucial component of the extracellular matrix (ECM) microfibrils, yet its role in liver fibrosis remains elusive. Methods: Human tissue arrays and mouse models progression resolution were used to investigate MFAP-2 expression patterns. Mfap2 deficiency (Mfap2 -/-) or overexpression (ovMfap2) mice subjected carbon tetrachloride (CCl4) injection bile duct ligation (BDL) induce fibrosis. Histological, biochemical, bulk, single-cell...
Abstract Background: High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein involved in the pathogenesis of chronic liver disease. HMGB1 expressed myeloid cells, including conventional dendritic cells (cDCs), which play major role tumor microenvironment. However, whether intracellular cell-derived hepatocellular carcinoma (HCC) unknown. We hypothesize that drives cDC maturation towards LAMP3+ DCs, allowing effective cytotoxic CD8+ T cell responses to reduce HCC....
Water stress is a frequent and critical limit to wheat (Triticum aestivum L.) production in North China. It has been shown that photosynthetic active radiation (PAR) closely related crop production. An experiment was conducted investigate the effects of deficit irrigation winter varieties on PAR capture ration, utilization grain yield. Field experiments involved Jimai 20 (J; high yield variety) Lainong 0153 (L; dryland with non-irrigation irrigated at jointing stage. The results showed...
Mortality from liver cancer in humans is increasingly attributable to heavy or long-term alcohol consumption. The mechanisms by which exerts its carcinogenic effect are not well understood. In this study, the role of alcohol-induced endoplasmic reticulum (ER) stress response development was investigated using an animal model with a knockout (KO) chaperone BiP and under constitutive hepatic ER stress. Long-term high fat diet feeding resulted higher levels serum alanine aminotransferase,...
Abstract Alcohol intoxication causes serious diseases, whereas current treatments are mostly supportive and unable to remove alcohol efficiently. Upon consumption, is sequentially oxidized acetaldehyde acetate by the endogenous dehydrogenase aldehyde dehydrogenase, respectively. Inspired metabolism of alcohol, a hepatocyte‐mimicking antidote for through codelivery nanocapsules oxidase (AOx), catalase (CAT), (ALDH) liver, where AOx CAT catalyze oxidation acetaldehyde, while ALDH catalyzes...