A5031666815- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Breast Lesions and Carcinomas
- Cancer-related molecular mechanisms research
- Cancer and Skin Lesions
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Polysaccharides Composition and Applications
- Kruppel-like factors research
- Mechanisms of cancer metastasis
- Cancer Research and Treatments
- Land Use and Ecosystem Services
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- Inflammatory mediators and NSAID effects
- Ubiquitin and proteasome pathways
Northwest A&F University
2024-2025
Nanjing University of Chinese Medicine
2025
China Medical University
2014-2024
First Hospital of China Medical University
2013-2024
South China Agricultural University
2022-2024
Weatherford College
2019
Peking Union Medical College Hospital
2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
First Affiliated Hospital of Liaoning Medical University
2014
Zhongda Hospital Southeast University
2013
The mechanism underlying breast cancer stem cell (BCSCs) characteristics remains to be fully elucidated. Accumulating evidence implies that long noncoding RNAs (lncRNAs) play a pivotal role in regulating BCSCs stemness.LncRNA LUCAT1 expression was assessed tissues (n = 151 cases) by situ hybridization. Sphere-formation assay and colony formation were used detect self-renewal proliferation, respectively. RNA immunoprecipitation, pull down luciferase reporter assays identify TCF7L2 as the...
CXCR4 and its ligand CXCL12 can promote the proliferation, survival, invasion of cancer cells. They have been shown to play an important role in regulating metastasis breast specific organs. High expression was also correlated poor clinical outcome. Previous study showed that tumor cells express a high level target tissues (lung, liver, bone) levels CXCL12, allowing directionally migrate organs via CXCL12-CXCR4 chemotactic gradient. However, exact mechanisms how enhance and/or growth their...
Abstract Breast cancer patients often suffer from disease relapse and metastasis due to the presence of breast stem-like cells (BCSCs). Numerous studies have reported that high levels inflammatory factors, including tumor necrosis factor alpha (TNF-α), promote BCSCs. However, mechanism by which TNF-α promotes BCSCs is unclear. In this study, we demonstrate up-regulates TAZ, a transcriptional co-activator promoting BCSC self-renewal capacity in human cell lines. Depletion TAZ abrogated...
Invasion and migration is the hallmark of malignant tumors as well major cause for breast cancer death. The polypyrimidine tract binding, PTB, protein serves an important model understanding how RNA binding proteins affect proliferation invasion changes in expression these can control complex programs tumorigenesis. We have investigated some roles 1 (PTBP1) human cancer. found that PTBP1 was upregulated tissues compared with normal same result confirmed cell lines. Knockdown substantially...
Krüppel-like factor 5 (KLF5) takes part in the pathologic processes of many types cancer; however, its expression and roles biological behavior gastric cancer remain unknown. TargetScan suggested that miR-145-5p is predicted effective conserved microRNA (miRNA) binds to KLF5 through 3'-untranslated region (UTR). We investigated messenger RNA (mRNA) then analyzed role cells. Our results indicated was detected by immunohistochemistry 39.7% cases increased compared with corresponding...
SMARCA5 partners with RSF-1 to compose the RSF complex, which belongs ISWI family of chromatin remodelers. Recent studies referred that was overexpressed in some malignant tumors. However, expression pattern and biological roles breast cancer have not been examined. In present study, we found specimens by immunohistochemistry. Significant association observed between overexpression TNM stage (p = 0.0199), tumor size 0.0066), high proliferation index 0.0366), poor overall survival 0.0141)....
Beclin 1, an important autophagy-related protein in human cells, is involved autophagy, differentiation, anti-apoptosis, and cancer progression, which increased during periods of cell stress extinguished the cycle. In order to clarify role 1 gastric carcinogenesis subsequent its expression was examined by immunohistochemistry situ hybridization (ISH) on tissue microarrays containing carcinomas, adjacent non-neoplastic mucosa, metastatic lymph node. Gastric carcinoma lines were studied for...
TSTA3 participates in enzyme metabolism and affects glycosylation processes, abnormal influences the malignant transformation of cells tumor development. However, studies have not examined molecular biological function breast cancer (BC). The expression was BC tissues cell lines. Kaplan-Meier survival tests Cox regression were used to analyze prognosis. depletion function. upstream miRNAs predicted, downstream target gene analyzed using a RT2 Profiler™ PCR array. Our results show that highly...
Activating transcription factor 4 (ATF4) is a member of the cAMP response element binding (CREB) protein family and has been reported to participate in cancer progression; however, its molecular mechanism not fully understood.In this study, we investigated function ATF4 non-small cell lung regulation.We detected cytoplasmic nuclear expression A549, H1299, LK2 cells, total was higher than that HBE cells (p < 0.05).Higher all these compared 0.05).Overexpression A549 significantly promoted...
Beclin 1 participates in development, autophagy, differentiation, anti- apoptosis, neurodegeneration, tumorigenesis and cancer progression. The roles of colorectal carcinogenesis its subsequent progression are still unclear. Here, the mRNA protein expression were determined carcinoma matched mucosa by Reverse transcriptase-polymerase chain reaction Western blot. Immunohistochemistry situ hybridization (ISH) performed on tissue microarryer with carcinoma, adenoma mucosa. was found to be...
In recent years, the incidence and mortality of cancer have witnessed a dramatic increase. Cancer has already caused severe economic burdens on society, especially in developing countries become major public health concern. This study evaluates medical burden, including total current curative expenditure (CCE) catastrophic (CHE) Liaoning Province, China. A 252 institutions were investigated with multistage stratified cluster random sampling. We established standardized database 3 532 517...