A5073611916- Genetic Mapping and Diversity in Plants and Animals
- Epilepsy research and treatment
- Genomics and Phylogenetic Studies
- Plant tissue culture and regeneration
- Chromosomal and Genetic Variations
- GABA and Rice Research
- EEG and Brain-Computer Interfaces
- Rice Cultivation and Yield Improvement
- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
- Neurological disorders and treatments
- Sleep and related disorders
- Tuberous Sclerosis Complex Research
- Plant Disease Resistance and Genetics
- Genomics and Rare Diseases
- High Altitude and Hypoxia
- Obsessive-Compulsive Spectrum Disorders
- Plant Molecular Biology Research
- Plant-Microbe Interactions and Immunity
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Music Perception
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
Agricultural Genomics Institute at Shenzhen
2022-2025
Chinese Academy of Agricultural Sciences
2022-2025
Ministry of Agriculture and Rural Affairs
2022-2025
China National Rice Research Institute
2022-2024
East China Normal University
2013-2023
Shandong Agricultural University
2017-2022
Nanjing Medical University
2021-2022
Huazhong Agricultural University
2022
Chinese PLA General Hospital
2006-2021
Wuxi People's Hospital
2021
Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity. Using de novo long-read assembly, we generated a graph-based super pan-genome of rice consisting 251-accession panel comprising both cultivated wild species Asian African rice. Our reveals extensive structural variations (SVs) gene presence/absence variations. Additionally, our enables the accurate identification nucleotide-binding leucine-rich repeat genes characterization their inter-...
ABSTRACT For sessile plants, gene expression plays a pivotal role in responding to salinity stress by activating or suppressing specific genes. However, our knowledge of genetic variations governing response salt remains limited natural germplasm. Through transcriptome analysis the Global Mini-Core Rice Collection consisting panel 202 accessions, we identified 22 345 and 27 610 quantitative trait loci associated with 7787 9361 eGenes under normal salt-stress conditions, respectively,...
Plant regeneration via somatic embryogenesis (SE) is a key step during genetic engineering. In the current study, integrated widely targeted metabolomics and RNA sequencing were performed to investigate dynamic metabolic transcriptional profiling of cotton SE. Our data revealed that total 581 metabolites present in nonembryogenic staged calli (NEC), primary embryogenic (PEC), initiation globular embryos (GE). Of differentially accumulated (DAMs), nucleotides, lipids specifically...
Transposable elements (TEs) are ubiquitous genomic components and hard to study due being highly repetitive. Here we assembled 232 chromosome-level genomes based on long-read sequencing data. Coupling the with 15 existing assemblies, developed a pan-TE map comprising both cultivated wild Asian rice. We detected 177 084 high-quality TE variations inferred their derived state using outgroups. found TEs were one source of phenotypic variation during rice domestication differentiation....
Detailed knowledge of the genetic variations in diverse crop populations forms basis for improvement and gene functional studies. In present study, we analyzed a large rice population with total 10 548 accessions to construct super-population variation map (RSPVM), consisting 54 378 986 single nucleotide polymorphisms, 11 119 947 insertion/deletion mutations 184 736 presence/absence variations. Assessment detection efficiency different sizes revealed sharp increase all types as size...
Abstract Background Schizophrenia (SZ) and obsessive-compulsive disorder (OCD) share many demographic characteristics severity of clinical symptoms, genetic risk factors, pathophysiological underpinnings, brain structure function. However, the differences in spontaneous activity patterns between two diseases remain unclear. Here this study aimed to compare features intrinsic treatment-naive participants with SZ OCD explore relationship symptoms. Methods In study, 22 SZ, 27 OCD, sixty healthy...
Because high temperatures impair rice production, it is desirable to elucidate the regulatory mechanisms involved in response heat stress. The objectives of this study were identify candidate genes and characterize their patterns during adaptation at seedling stage. Ten heat-associated quantitative-trait loci identified a genome-wide association study. Comparison transcript abundances heat-sensitive heat-tolerant pools under stress revealed approximately 400 differentially expressed genes....
Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key non-rapid eye movement (NREM) sleep parameters across multiple domains, their interdependencies, and relationship waking event-related potentials symptom severity. In 72 schizophrenia (SCZ) 58 controls, confirmed a marked reduction spindle density SCZ extended these findings show that fast slow properties were...
Tandem repeats (TRs) are genomic regions that tandemly change in repeat number, which often multiallelic. Their characteristics and contributions to gene expression quantitative traits rice largely unknown. Here, we survey TR variations based on 231 genome assemblies the pan-genome graph. We identify 227,391 multiallelic loci, including 54,416 absent from Nipponbare reference genome. Only 1/3 show strong linkage with nearby bi-allelic variants (SNPs, Indels PAVs). Using 193 panicle 202 leaf...
Continuously increasing global temperatures present great challenges to food security. Grain size, one of the critical components determining grain yield in rice (Oryza sativa L.), is a prime target for genetic breeding. Thus, there an immediate need improvement maintain under heat stress. However, quantitative trait loci (QTLs) endowing stress tolerance and size are extremely rare. Here, we identified novel negative regulator with pleiotropic effects, Thermo-Tolerance Length 1 (TTL1), from...
Abstract Alternative splicing (AS) plays crucial roles in regulating various biological processes plants. However, the genetic mechanisms underlying AS and its role controlling important agronomic traits rice (Oryza sativa) remain poorly understood. In this study, we explored leaves panicles using minicore collection. Our analysis revealed a high level of transcript isoform diversity, with approximately one-fifth potential isoforms acting as major transcripts both tissues. Regarding...
Abstract Rice ( Oryza sativa ) is a significant crop worldwide with genome shaped by various evolutionary factors. centromeres are crucial for chromosome segregation, and contain some unreported genes. Due to the diverse complex centromere region, comprehensive understanding of rice structure function at population level needed. We constructed high‐quality map based on super pan‐genome consisting 251‐accession panel comprising both cultivated wild species Asian African rice. showed that have...
As a notable illustration of totipotency, somatic embryogenesis (SE) is the developmental reprogramming cells towards pathway (Yang and Zhang, 2010). Investigations examining totipotency process are great fundamental practical importance in crop biotechnology. Moreover, high-frequency regeneration SE has been limited due to genotype-dependent response. To date, epigenetic molecular basis underlying embryogenic redifferentiation during remains largely unexplored. Plant accompanied by changes...
Quality is a complex trait that not only the key determinant of market value rice grain, but also major constraint in breeding. It influenced by both genetic and environmental factors. However, combined effects genotypes factors on grain quality remain unclear. In this study, we used three-factor experimental design to examine different Wx grown under nitrogen fertilization temperature conditions during development. We found three contributed differently taste, appearance, nutritional...
ABSTRACT We report the first patient to die from refractory convulsive status epilepticus (SE) after removal of a stimulator. The occurred two‐year period successful control super‐refractory SE with deep brain stimulation bilateral anterior nucleus thalamus (ANT‐DBS). female patient, born in 1990, suffered high fever and seizures, was diagnosed viral encephalitis 2005. After four weeks medical treatment, she recovered no neurological disabilities, but monthly seizures. Ten years later,...
Plant somatic cells can reprogram into differentiated embryos through embryogenesis (SE) on the condition of plant growth regulators (PGRs). RNA sequencing analysis was performed to investigate transcriptional profiling cotton redifferentiated callus that induced by different auxin types (IAA and 2,4-D), concentrations (0, 0.025, 0.05 mg L-1), incubation times 5, 20 days). Under 2,4-D induction effect, signal transduction pathways hormones were significantly enriched in embryogenic response...
ABSTRACT Glycosylation, a prevalent post‐translational modification in eukaryotic secreted and membrane‐associated proteins, plays pivotal role diverse physiological pathological processes. Although UDP‐ N‐ acetylglucosamine (UDP‐GlcNAc) is essential for this modification, the specific glycosylation mechanisms during plant leaf senescence defense responses remain poorly understood. In our research, we identified novel rice mutant named rbb1 (resistance to blast bacterial blight1), exhibiting...
Fungi are the causal agents of many world's most serious plant diseases causing disastrous consequences for large-scale agricultural production. Pathogenicity genomic basis is complex in fungi as multicellular eukaryotic pathogens. Here, we report genome sequence C. sojina, and comparative analysis with pathogen members genus Mycosphaerella (Zymoseptoria. tritici (synonyms M. graminicola), pini, populorum fijiensis - pathogens wheat, pine, poplar banana, respectively). Synteny or...
Aims: To prospectively study the surgical outcomes of unilateral anterior temporal lobectomy (ATL) in patients with intractable bilateral lobe epilepsy (TLE) as well two-staged contralateral hippocampal stimulation after failed ATL. Methods: Eighteen carefully selected TLE underwent Five cases ATL stimulation. Seizure control and changes intelligence quotient (IQ), memory quotient, quality life (QOL) were analyzed 2-5 years treatment. Results: In ATL, percentages seizure free 55.6% (10/18),...