A5101716193- Autophagy in Disease and Therapy
- CAR-T cell therapy research
- Cancer-related gene regulation
- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lipoproteins and Cardiovascular Health
- Biomarkers in Disease Mechanisms
- Advanced Fiber Laser Technologies
- Pancreatic and Hepatic Oncology Research
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Renal Diseases and Glomerulopathies
- Cardiac Fibrosis and Remodeling
- Ear Surgery and Otitis Media
- Acute Myeloid Leukemia Research
- Adipose Tissue and Metabolism
- Lymphoma Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Chronic Kidney Disease and Diabetes
- Botanical Studies and Applications
- Fluoride Effects and Removal
Inner Mongolia Agricultural University
2025
Harbin Engineering University
2024
Hangzhou Normal University
2024
Huazhong University of Science and Technology
2013-2024
Tongji Hospital
2016-2024
First Affiliated Hospital of Xi'an Jiaotong University
2009-2024
Tongji University
2024
Taiyuan University of Technology
2023
People’s Hospital of Rizhao
2023
Jining Medical University
2023
Significance Cancer stem cells (CSCs) frequently acquire the ability to self-renew and persist in their hosts by coopting normal cell programs. Blast crisis (BC) chronic myeloid leukemia is a prototypic example, as acquired activation of β-catenin signaling that enables BC CSC function also important hematopoietic maintenance. In identifying eIF4E phosphorylation MNK kinases necessary step CSCs, but not cells, we define therapeutic target BC. Our studies suggest clinical trials with kinase...
Histone arginine methylation, which is catalyzed by protein methyltransferases (PRMTs), plays a key regulatory role in various biological processes. Several PRMTs are involved skeletal development; however, their the osteogenic differentiation of mesenchymal stem cells (MSCs) not completely clear. In this study, we aimed to elucidate function PRMT3, type-I PRMT that catalyzes formation ω-mono- or asymmetric dimethyl arginine, MSCs osteogenesis. We found PRMT3 promoted commitment and bone...
Abstract Objectives The hypoxia-inducible factor 1-α (HIF1α), a key molecule in mediating bone-vessel crosstalk, has been considered promising target for treating osteoporosis caused by gonadal hormones. However, senile osteoporosis, with accumulated senescent cells aged bone, distinct pathogenesis. study aimed at revealing the unknown role of HIF1α thus broadening its practical application osteoporosis. Materials and methods Femurs tibias were collected from untreated mice various ages (2...
Post-translational modifications of autophagy-related (ATG) genes are necessary to modulate their functions. However, ATG protein methylation and its physiological role have not yet been elucidated. The non-histone proteins by SETD7, a SET domain-containing lysine methyltransferase, is novel regulatory mechanism control cell function in response various cellular stresses. Here we present evidence that the precise activity ATG16L1 hypoxia/reoxygenation (H/R)-treated cardiomyocytes regulated...
Background:It has previously been demonstrated that apolipoprotein A-1 (apoA-1) binding protein (AIBP) promotes apoA-1 to ATP-binding cassette transporter A1 (ABCA1) and prevents ABCA1 degradation so as inhibit foam cell formation. Because inhibits inflammatory signaling pathways, whether AIBP an inhibitory effect on pathways in THP-1-derived macrophages is investigated.
Decorin ( DCN ) is a major member of the small leucine‐rich proteoglycan SLRP family that critically involved in tumorigenesis and development metastasis cancers, including glioma. Overexpression was indicated to suppress glioma cell growth. However, role migration cells remain elusive. In this study, we found treatment with exogenous inhibited adhesion U87 MG down‐regulation TGF ‐β signaling. also activated autophagy, as by monodansylcadaverine MDC staining, increase LC 3 I/ II conversion,...
CD4+ T cells are abnormally activated in patients with dilated cardiomyopathy (DCM) and might be associated the immunopathogenesis of disease. However, underlying mechanisms cell activation remain largely undefined. Our aim was to investigate whether dysregulation microRNAs (miRNAs) DCM. from DCM showed increased expression levels CD25 CD69 enhanced proliferation response anti-CD3/28, indicating an state. miRNA profiling analysis magnetically sorted revealed a distinct pattern compared...
SIRT6 has been identified as an H3K9 deacetylase and a critical regulator of genome stability, telomere integrity, metabolic homeostasis. Sirt6-deficient mice displayed dramatic phenotypes including profound lymphopenia, loss subcutaneous fat, lordokyphosis low bone marrow density. Here, we report that regulates osteogenic differentiation independent its activity in vitro. Further mechanistic studies showed involves the cell fate determination by modulating morphogenetic protein (BMP)...
Mesenchymal stem cells (MSCs) are a reliable resource for bone regeneration and tissue engineering, but the molecular mechanisms of differentiation remain unclear. The tumor antigen 15-leucine-rich repeat containing membrane protein (LRRC15) is transmembrane demonstrated to play important roles in cancer. However, little known about its role osteogenesis. This study was evaluate functions LRRC15 osteogenic MSCs. Osteogenic-induction treatment ovariectomized (OVX) model were performed...
The E3 ubiquitin ligase complex CDC20-activated anaphase-promoting complex/Cyclosome (APC/CCDC20 ) plays a critical role in governing mitotic progression by targeting key cell cycle regulators for degradation. Cell division protein 20 homolog (CDC20), the co-activator of APC/C, is required full activity. In addition to its well-known cycle-related functions, we demonstrate that CDC20 an essential osteogenic commitment bone marrow mesenchymal stromal/stem cells (BMSCs). Cdc20 conditional...
Chimeric antigen receptor (CAR) T cell therapy has markedly improved the prognosis of patients with diffuse large B-cell lymphoma (DLBCL). The relative positioning tumor lesions in varies among patients, manifesting as either aggregation (clumped together) or dissemination (spread throughout body). Prognostic significance factors indicating CAR remains underexplored. For aggregation, prior research proposed volume surface ratio (TVSR), linking it to chemotherapy. Regarding dissemination,...
Testes development is a fundamental process in sexual and reproduction. The testes undergo dramatic structural changes during development, including the proliferation differentiation of somatic cells such as Sertoli cells, Leydig myoid well maturation spermatogonia. However, little known about onset spermatogenesis cell spermatogonial niche large animals. We used single-cell RNA sequencing (scRNA-seq) to profile nearly 100,000 from Hu sheep across seven developmental stages (birth,...
// Yan-Rong Liu 1, * , Lan Liang 3, Jian Min Zhao 4, Yang Zhang 5, 2 Wei-Long Zhong Qiang Jun-Jie Wei Meng Li Jie Yuan Shuang Chen 1 Shu-Min Zong Hui-Juan Jing Qin Bo Sun Hong-Gang Zhou Tao and Cheng Tianjin Key Laboratory of Molecular Drug Research, International Joint Academy Biomedicine, Tianjin, China State Medicinal Chemical Biology College Pharmacy, Nankai University, 3 GoalGen Biotechnology Co., Ltd., 4 Pathology Department, Shun Yi District Hospital, Beijing, 5 Department...
It has been suggested that cerebral blood flow (CBF) alterations may be involved in the pathogenesis of Alzheimer's disease (AD). However, how CBF changes with age not detailed AD, particularly its early stages. The objective present study was to evaluate four brain regions (the hippocampus, entorhinal cortex, frontoparietal cortex and thalamus) mice groups, mimic respective stages AD humans [2 months (pre‑clinical), 3.5 (sub‑clinical), 5 (early‑clinical) 8 (mid‑clinical)], understand...
Abstract Latest clinical research shows that trimetazidine therapy during the perioperative period relieves endothelial dysfunction in patients with unstable angina induced by percutaneous coronary intervention. In this study we investigated effects of TMZ on myocardial angiogenesis pressure overload-induced cardiac hypertrophy mice. Cardiac was mice transverse aortic constriction (TAC) surgery. TAC were administered (2.8 mg/100 µL, i.g.) for 28 consecutive days. We showed administration...
ABSTRACT Previously, we identified a single nucleotide mutation in the promoter ( mutp ) of fluoride antiporter-coding genes naturally fluoride-resistant Streptococcus mutans strain. Here, studied role this defined genetic background. The results confirmed that alone confers resistance on S. , as shown by growth and lactic acid production assays. This was explained constitutively higher activity upregulation genes.
New Delhi metallo‐beta‐lactamase‐1(NDM‐1)‐carrying isolates, which are resistant to most clinical used antibiotics except for tigecycline and colistin, have been found worldwide. Cathelicidin‐BF (BF‐30) is in the venom of snake Bungarus fasciatus exhibits broad antimicrobial activity. Cbf‐K 16 Cbf‐A 7 A 13 were obtained by mutating Lys , Ala BF‐30, respectively. To investigate their activities against NDM‐1 carrying bacteria, recombinant Escherichia coli BL21 (DE3)‐NDM‐1 with high activity...
Pancreatic cancer is the fourth most common cause of mortality worldwide. Furthermore, patients with pancreatic experience limited benefit from current chemotherapeutic approaches because drug resistance. Therefore, an effective therapeutic strategy for urgently required. Deguelin a natural chemopreventive that exerts potent antiproliferative activity in solid tumors by inducing cell death. However, molecular mechanisms underlying this have not been fully elucidated. Here we show deguelin...