A5101930711- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Sleep and Wakefulness Research
- Anesthesia and Sedative Agents
- Advanced MRI Techniques and Applications
- Adipose Tissue and Metabolism
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Functional Brain Connectivity Studies
- Trigeminal Neuralgia and Treatments
- Olfactory and Sensory Function Studies
- Receptor Mechanisms and Signaling
- Autophagy in Disease and Therapy
- Viral-associated cancers and disorders
- Pain Management and Treatment
- Histiocytic Disorders and Treatments
- Medicinal Plants and Bioactive Compounds
- Sparse and Compressive Sensing Techniques
- Migraine and Headache Studies
- EEG and Brain-Computer Interfaces
- Phytochemical compounds biological activities
- Pediatric Pain Management Techniques
Zunyi Medical University
2016-2025
University of Science and Technology of China
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Guangzhou University of Chinese Medicine
2024
Xinjiang Medical University
2024
Vanderbilt University
2023-2024
Huashan Hospital
2023
Fudan University
2023
Liaoning University of Traditional Chinese Medicine
2022
GTx (United States)
2019
Post-translational modifications of autophagy-related (ATG) genes are necessary to modulate their functions. However, ATG protein methylation and its physiological role have not yet been elucidated. The non-histone proteins by SETD7, a SET domain-containing lysine methyltransferase, is novel regulatory mechanism control cell function in response various cellular stresses. Here we present evidence that the precise activity ATG16L1 hypoxia/reoxygenation (H/R)-treated cardiomyocytes regulated...
Abstract At present, the mechanisms by which general anesthetics causing loss of consciousness remain unclear. The central medial thalamic nucleus ( CMT ) is a rarely studied component midline complex, deemed to be part nonspecific arousal system. Although participates in modulating and receives excitatory noradrenergic projections from locus coeruleus, it remains unknown whether pathway takes Therefore, we hypothesized that transmission involved induction emergence propofol anesthesia....
How general anesthesia causes loss of consciousness has been a mystery for decades. It is generally thought that arousal-related brain nuclei, including the locus coeruleus (LC), are involved. Here, by monitoring locomotion behaviors and neural activities, we developed larval zebrafish model studying induced propofol etomidate, two commonly used intravenous anesthetics. Local lesion LC neurons via two-photon laser-based ablation or genetic depletion norepinephrine (NE; neuromodulator...
Electroencephalogram monitoring during propofol (PRO) anesthesia typically features low-frequency oscillations, which may be involved with thalamic reticular nucleus (TRN) modulation. TRN receives noradrenergic inputs from the locus coeruleus (LC). We hypothesized that specific connections in contribute to emergence PRO anesthesia. Intranuclei norepinephrine (NE) injections (n = 10) and designer receptors exclusively activated by drugs (DREADDs) were used investigate role of LC Whole-cell...
To identify the changes of local coherence and intrinsic brain activity in resting-state idiopathic trigeminal neuralgia (ITN) patients by using regional homogeneity (ReHo) fractional aptitude low-frequency fluctuation (fALFF) analysis.
To determine if heroin body packing has occurred using computed tomography (CT), and to evaluate the role of CT in screening such cases.We collected 158 cases suspected drug packers' imaging materials (all underwent CT, 42 were imaged plain x-ray film) from September 5, 2005 April 23, 2008. Abdominal-pelvic appearances (shape, size, number, location density) abdominal film manifestations retrospectively observed for those who finally confirmed as packers through passing evacuated...
The parabrachial nucleus (PBN) promotes wakefulness states under general anesthesia. Recent studies have shown that glutamatergic neurons within the PBN play a crucial role in facilitating emergence from Our previous study indicates vesicular glutamate transporter 2 (vglut2) expression of extend into extended amygdala (EA). However, modulation
Background: Astrocytes are now considered as crucial modulators of neuronal synaptic transmission. General anesthetics have been found to inhibit astrocytic activities, but it is not clear whether general within the clinical concentration range affects astrocyte-mediated regulation. Methods: The effects propofol, dexmedetomidine, and ketamine clinically effective ranges on slow inward currents (SICs) were tested by using whole-cell recording in acute prefrontal cortex (PFC) slice...
Background The mechanism by which general anesthetics, widely used in clinical practice for over 160 years, effects on sensory responsiveness has been unclear until now. In the present study, authors sought to explore effect of different doses propofol somatosensory cortex whisker stimulation rats. Methods a fixed cage, rats were anesthetized with 80 mg/kg intraperitoneally and then cathetered tail vein 23-gauge metal needle connected pump. Two holes (2 mm diameter) drilled recording...
Intravenous anesthetics have been used clinically to induce unconsciousness for seventeen decades, however the mechanism of anesthetic‑induced remains be fully elucidated. It has previously demonstrated that exert sedative effects by acting on endoge-nous sleep‑arousal circuits. However, few studies focus ventrolateral pre‑optic (VLPO) locus coeruleus (LC) pathway. The present study aimed investigate if VLPO is involved in induced propofol. additionally investigated inhibitory effect...
Multimodal magnetic resonance imaging (MRI) was used to detect whether 6 months after pain relieving, the structural and functional abnormalities in brain of postherpetic neuralgia (PHN) patients are changeable.Fifteen successfully treated PHN were enrolled; activity detected compared before treatment. The parameters evaluated with resting-state MRI technique, i.e., regional homogeneity (ReHo) fractional amplitude low-frequency fluctuation (fALFF). Structural changes voxel-based...
Mitochondrial ATP-sensitive potassium channel (mito<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:msub><mml:mrow><mml:mtext>K</mml:mtext></mml:mrow><mml:mrow><mml:mtext>ATP</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>) is a common end effector of many protective stimuli in myocardial ischemia-reperfusion injury (MIRI). However, the specific molecular mechanism underlying its effect not well elucidated. We characterized an anoxia/reoxygenation (A/R)...